Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Disclosed are nucleic acid sequences capable of encoding peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Also disclosed are methods for eliciting a protective immune response against RSV comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by FcRn; a modified pre-fusion RSV F protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.

Abstract: The disclosure describes aspects of laser cavity optical alignment, and more particularly, in situ alignment of optical devices in an optical system for replacement or upgrade. In one aspect, a method for optical alignment in an optical system is described that includes providing, via a positioning system, an optical beam to measure surface features and position of a first device under test (DUT), removing the first DUT from the optical system, placing a second DUT in the optical system at substantially the same position from which the first DUT was removed, providing, via the positioning system, an optical beam to measure surface features and position of the second DUT, aligning the second DUT based on the measurements made of the first DUT and the second DUT, and verifying operation of the second DUT in the optical system. The DUT can be an optical device such as an output optical coupler.

Abstract: An ion-conducting structure comprises a metal-fibril complex formed by one or more elementary nanofibrils. Each elementary nanofibril can be composed of a plurality of cellulose molecular chains with functional groups. Each elementary nanofibril can also have a plurality of metal ions. Each metal ion can act as a coordination center between the functional groups of adjacent cellulose molecular chains so as to form a respective ion transport channel between the cellulose molecular chains. The metal-fibril complex can comprise a plurality of second ions. Each second ion can be disposed within one of the ion transport channels so as to be intercalated between the corresponding cellulose molecular chains. In some embodiments, the metal-fibril complex is formed as a solid-state structure.

Abstract: Systems and methods of synthesizing nanoparticles on substrates using rapid, high temperature thermal shock. A method involves depositing micro-sized particles or salt precursors on a substrate, and applying a rapid, high temperature thermal shock to the micro-sized particles or the salt precursors to become nanoparticles on the substrate. A system may include a rotatable member that receives a roll of a substrate sheet having micro-sized particles or salt precursors; a motor that rotates the rotatable member so as to unroll the substrate; and a thermal energy source that applies a short, high temperature thermal shock to the substrate. The nanoparticles may be metallic, ceramic, inorganic, semiconductor, or compound nanoparticles. The substrate may be a carbon-based substrate, a conducting substrate, or a non-conducting substrate. The high temperature thermal shock process may be enabled by electrical Joule heating, microwave heating, thermal radiative heating, plasma heating, or laser heating.

Abstract: The disclosure describes various aspects of a practical implementation of multi-qubit gate architecture. A method is described that includes enabling ions in the ion trap having three energy levels, enabling a low-heating rate motional mode (e.g., zig-zag mode) at a ground state of motion with the ions in the ion trap; and performing a Cirac and Zoller (CZ) protocol using the low-heating rate motional mode as a motional state of the CZ protocol and one of the energy levels as an auxiliary state of the CZ protocol, where performing the CZ protocol includes implementing the multi-qubit gate. The method also includes performing one or more algorithms using the multi-qubit gate, including Grover's algorithm, Shor's factoring algorithm, quantum approximation optimization algorithm (QAOA), error correction algorithms, and quantum and Hamiltonian simulations. A corresponding system that supports the implementation of a multi-qubit gate architecture is also described.

Abstract: Sample collection tubes and methods of producing the same are provided. Contemplated collection tubes comprise a tube having a separator substance disposed therein. In some aspects, the separator substance preferably maintains a predetermined flowability during irradiation or heat sterilization, and can subsequently polymerize upon exposure to a UV light or other suitable source.

Abstract: The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions.

Abstract: A topological photonic system configured as a robust source of indistinguishable photons pairs with tunable spectral correlations. The system includes a two-dimensional silicon-photonic ring resonator array configured to implement an anomalous-quantum Hall model that exhibits topologically robust edge states. Linear dispersion of the edge states ensures efficient and robust phase matching and tunability of the spectral bandwidth of photon pairs generated via spontaneous four-wave mixing. Spectral tunability is manifested in the temporal correlations in the Hong-Ou-Mandel interference between photons. The generated photon pairs are energy-time entangled.

Abstract: A vision guided intelligent system for automated crab meat picking operates in a fully automated or semi-automatic modes of operation using a crab meat picking routine based on (a) the CNN model localization of back-fin knuckles algorithm, and/or (b) the Deep Learning model which accurately locates not only knuckle positions, but also crab legs and crab cores, with a high pixel accuracy (up to 0.9843), and low computation time. The subject system uses a concept of analyzing crab morphologies obtained from digital crab images, and, using a Deep Learning architecture integrated in the system, segments crab images into five regions of interest in a single step with high accuracy and efficiency. The image segmentation results are used for generating crab cut lines in XYZ and angular directions, determining starting cutting points in Z plane, and guiding cutting tools and end effectors to automatically cut crabs and harvest crab meat.

Abstract: The present disclosure provides stable elastocaloric cooling materials and methods for producing and using the same. Elastocaloric cooling materials of the present disclosure are capable of withstanding 106 cycles. In some embodiments, elastocaloric cooling materials of the present disclosure comprise a mixture of a transforming alloy and a non-transforming intermetallic phase at a ratio of from about 30-70% transforming alloy to about 70%-30% of non-transforming intermetallic phase.

Abstract: The disclosure describes aspects of using multiple species in trapped-ion nodes for quantum networking. In an aspect, a quantum networking node is described that includes multiple memory qubits, each memory qubit being based on a 171Yb+ atomic ion, and one or more communication qubits, each communication qubit being based on a 138Ba+ atomic ion. The memory and communication qubits are part of a lattice in an atomic ion trap. In another aspect, a quantum computing system having a modular optical architecture is described that includes multiple quantum networking nodes, each quantum networking node including multiple memory qubits (e.g., based on a 171Yb+ atomic ion) and one or more communication qubits (e.g., based on a 138Ba+ atomic ion). The memory and communication qubits are part of a lattice in an atomic ion trap. The system further includes a photonic entangler coupled to each of the multiple quantum networking nodes.

Abstract: Sample collection tubes and methods of producing the same are provided. Contemplated collection tubes comprise a tube having a separator substance disposed therein. In some aspects, the separator substance preferably maintains a predetermined flowability during irradiation or heat sterilization, and can subsequently polymerize upon exposure to a UV light or other suitable source. In other aspects, the separator substance preferably includes a soft gel component (thixotropic gel), and a photocurable sealant component that is formulated to polymerize and form a solid barrier between fractions of a liquid.

Abstract: The disclosure provides rechargeable lithium ion batteries comprising at least one lithium salt-graphite composite electrode. In particular, the disclosure provides a rechargeable “water-in-bisalt” lithium ion battery with a high potential where at least a portion of the lithium salt is phase separated from the aqueous electrolyte, and where the anionic-redox reaction occurs within the graphitic lattice.

Abstract: In some embodiments, systems, methods, and media for automatically identifying entrepreneurial individuals in a population using individual and population level data are provided. In some embodiments, a system is provided, comprising: a database storing: grades and identifying information for classes; a hardware processor configured to: calculate, for each class, a difficulty value based on the grade for each individual; modify grades associated with the individual based on the difficulties; determine a variance using the modified grades; determine an average variance; determine that the variance for a first individual is larger average; determine that the first individual is more likely than average to be entrepreneurial; in response to determining that the first individual is more likely than average to be entrepreneurial, add identifying information of the first student to a second database of potential entrepreneurs.

Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

Abstract: A retention media for removing substances from water that includes an aggregate; at least one granular adsorbing material capable of adsorbing nutrients and metals; and a psyllium, wherein the psyllium performs as a binder to adhere the at least one granular adsorbing material to the aggregate to form a high permeability media mix is disclosed. A method of manufacturing a media mix is disclosed that includes creating a dry mixture of aggregate, at least one granular absorbing material, and a psyllium; and saturating the dry mixture with water to create a bond between the at least one granular absorbing material, and the aggregate via the psyllium thereby forming a high permeability media mix (HPMM). A method of using a media mix to reduce concentration of substances in water includes installing materials over granular adsorbing material, aggregate; and psyllium to reduce concentration of phosphorous or nitrogen or metals in the water.

Abstract: Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.

Abstract: An optomechanical pressure-measurement system measures pressure in the range of 10?6 Pa-10?2 Pa by measuring various properties of a vibrational mode of an ultra-thin membrane member. With independent measurements of the thickness and density of the membrane, in addition to the measured vibration mode properties, the system can operate as a primary pressure sensor. The membrane member is mounted on a vibration-isolated mount and is excited by a drive force. A laser beam impinges on the excited membrane, and an optical phase detector detects the amplitude of the oscillations, as well as parameters of the laser beam affected by the membrane vibration. In one embodiment, a mechanical damping is computed based on the amplitude or frequency shift (depending on the pressure range), and the pressure based on the ring-down time of the membrane vibration mode.

Abstract: The present disclosure provides a stable ceramic anode for a solid oxide fuel cell (SOFC) and a method for producing and using the same. In particular, anodes for solid oxide fuel cells disclosed herein can be operated at a significantly lower temperature than conventional SOFCs, and allow thermal and anode gas cycling under transient conditions. More significantly, anodes described in the present disclosure have a significantly higher long-term operability compared to a similar anode having a higher amount of electrocatalyst. In one particular embodiment, the stable ceramic anodes comprise (i) strontium-iron-cobalt-molybdenum oxide (SFCM) material; (ii) a first ion-conductor composition comprising an oxide of cerium or cerium that is doped with a rare-earth metal; and (iii) nanoparticles of an electrocatalyst comprising (a) a second ion-conductor and (b) nickel, a nickel alloy, or a combination thereof. The amount of electrocatalyst in said stable ceramic anode is less than 10 wt %.

Abstract: A formation of multielement nanoparticles is disclosed that includes at least three elements. Each of the at least three elements is uniformly distributed within the multielement nanoparticles forming nanoparticles having a homogeneous mixing structure. At least five elements may form a high-entropy nanoparticle structure. A method for manufacturing a formation of multielement nanoparticles includes providing a precursor material composed of the at least three component elements in multielement nanoparticles; heating the precursor material to a temperature and a time; and quenching the precursor to a temperature at a cooling rate to result in a formation of multielement nanoparticles containing at least three elements and the heating and the quenching representing a multielement nanoparticle thermal shock formation process. A corresponding system for manufacturing the formation of multielement nanoparticles and a method of using the multielement nanoparticles are also disclosed.