Abstract: The present invention relates an indicator system for assessing a reduction state of unconsolidated material that includes a delivery tube defining an interior chamber, and a substrate disposed within the interior chamber and including a reactive coating thereon. The reactive coating is at least partially removable from the substrate upon exposure to a reducing condition of unconsolidated material over a period of time. An indicator device including a reactive coating comprising a manganese oxide is also disclosed.
Abstract: A method and apparatus for monitoring collection of subject condition data is provided. The method includes receiving a value of a parameter of subject condition data and a value of a sample time, for each of a plurality of sample times. The method also includes storing the subject condition data in a data structure including a first field for holding data indicating a current sample time and a second field for holding data indicating the value of the parameter. The method also includes determining a time gap defined by a duration between the current sample time and a most recent sample time and determining whether the time gap exceeds a time gap threshold and causing an apparatus to perform remedial action. A method for presenting the subject condition data on a display is also provided.
Type:
Grant
Filed:
February 21, 2022
Date of Patent:
May 16, 2023
Assignee:
University of Maryland, Baltimore
Inventors:
Fu-Ming Hu, Lynn G. Stansbury, Colin F. Mackenzie, Thomas M. Scalea, Deborah M. Stein, Shiming Yang
Abstract: The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.
Abstract: Solid-state lithium ion electrolytes of lithium fluoride based composites are provided which contain an anionic framework capable of conducting lithium ions. Composites of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are provided. Electrodes containing the lithium fluoride based composites are also provided.
Type:
Application
Filed:
December 27, 2022
Publication date:
May 4, 2023
Applicants:
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Chen LING, Ying ZHANG, Yifei MO, Qiang BAI
Abstract: An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line operational mode where the oxygen supply unit is being powered by battery only, a larger flow of recycled gas from the blood oxygenator is passed through the carbon dioxide scrubber and combined with a lesser amount of oxygen-rich gas from the oxygen concentrator. The oxygen supply unit may be used in combination with a blood pump and oxygenator to provide ambulatory blood oxygenation to patients with compromised lung function.
Type:
Grant
Filed:
August 14, 2019
Date of Patent:
May 2, 2023
Assignees:
University of Maryland, Baltimore, Breethe, Inc.
Inventors:
Zhongjun Wu, Bartley Griffith, David N. Wells
Abstract: Solid-state lithium ion electrolytes of metal lithium chloride derivative compounds having a crystal morphology in the P21/c space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.15 to 0.40 eV and conductivities are from 0.01 to 3 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
Type:
Grant
Filed:
June 23, 2020
Date of Patent:
May 2, 2023
Assignees:
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Abstract: Provided herein are magnetically-responsive, photosensitizer based antimicrobial microemulsions and photodynamic nanoplatforms in which a photosensitizer functionally associated with a plurality of superparamagnetic iron oxide nanoparticles are encapsulated. Also provided are methods and processes utilizing the antimicrobial microemulsions and photodynamic nanoplatforms to treat an oral disease, to reduce a microbial population in a pathogenic oral biofilm and to improve the efficacy of a photosensitizer during an antimicrobial photodynamic therapy treatment of an oral disease.
Type:
Application
Filed:
October 20, 2022
Publication date:
April 27, 2023
Applicant:
University of Maryland, Baltimore
Inventors:
Mary Anne Melo, Abdulrahman A. Balhaddad, Michael D. Weir, Huakun Xu
Abstract: Solid-state lithium ion electrolytes of lithium metal nitride based compounds are provided which contain an anionic framework capable of conducting lithium ions. Materials of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are provided. Electrodes containing the lithium metal nitride based composites are also provided.
Type:
Application
Filed:
December 22, 2022
Publication date:
April 27, 2023
Applicants:
UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
Abstract: Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.
Abstract: Provide herein are compounds with a general chemical structure of: Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.
Type:
Grant
Filed:
May 3, 2019
Date of Patent:
April 25, 2023
Assignees:
University of Maryland, Baltimore, The United States of America as Represented by the
Department of Veterans Affairs
Inventors:
Antonino Passaniti, Alexander D. MacKerell, Jr.
Abstract: The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R8, R9, R10 and R11 may be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof.
Type:
Grant
Filed:
October 4, 2017
Date of Patent:
April 25, 2023
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE
Inventors:
Robert K. Ernst, Erin M. Harberts, Alison J. Scott
Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.
Type:
Grant
Filed:
April 20, 2020
Date of Patent:
April 25, 2023
Assignees:
University of Maryland, Baltimore, The Board of Regents of the University of Texas System, Broncus
Inventors:
Amit Sawant, Robert Timmerman, Yulong Yan, Henky Wibowo, Esther Vicente, Arezoo Modiri
Abstract: Various face discrimination systems may benefit from techniques for providing increased accuracy. For example, certain discriminative face verification systems can benefit from L2-constrained softmax loss. A method can include applying an image of a face as an input to a deep convolutional neural network. The method can also include applying an output of a fully connected layer of the deep convolutional neural network to an L2-normalizing layer. The method can further include determining softmax loss based on an output of the L2-normalizing layer.
Type:
Grant
Filed:
March 28, 2018
Date of Patent:
April 25, 2023
Assignee:
UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Rajeev Ranjan, Carlos Castillo, Ramalingam Chellappa
Abstract: Disclosed are devices and methods for automated emergency arterial cannulation. The device comprises a hand-held automated emergency arterial sheath placement device having a body with a handle and an actuator, and an arterial sheath placement head at the distal end of the handle body configured for placement against the patient's skin. The arterial sheath placement head includes an arterial sheath insertion device configured to advance an arterial needle, guide wire, and arterial sheath into a patient's artery upon sequential operation of the actuator. The arterial sheath placement head also includes a non-invasive artery locator configured to locate an artery into which the arterial sheath is intended to be placed. The arterial sheath placement head also preferably includes a Doppler gel and antiseptic needle, a local anesthetic needle, and a scalpel, all of which are likewise configured to advance from the upper body portion upon sequential operation of the actuator.
Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.
Type:
Grant
Filed:
January 7, 2019
Date of Patent:
April 18, 2023
Assignees:
University of Maryland, College Park, The United States of America as Represented by the Secretary of the Army
Inventors:
Matthew D. Widstrom, Peter Kofinas, Arthur V. Cresce, Kang Xu
Abstract: Novel retinamides with unique properties and biological activities, including inhibition of retinoic acid metabolism and modulation of Mnk1/2-eIF4E and androgen receptor (AR) signaling pathways, are synthesized and developed. The novel retinamides are capable of effecting treatment of a variety of dermatological conditions while limiting adverse side effects.
Type:
Application
Filed:
December 18, 2020
Publication date:
April 13, 2023
Applicant:
UNIVERSITY OF MARYLAND, Baltimore
Inventors:
Vincent C.O. NJAR, Senthilmurugan RAMALINGAM, Lalji K. GEDIYA, Hannah W. MBATIA, Vidya P. RAMAMURTHY
Abstract: Prodrugs of colchicine, de-acetyl colchicine, colcemid, and nocodazole are provided as therapies for the treatment of diseases ameliorated by the inhibition of microtubule polymerization.
Type:
Grant
Filed:
June 19, 2018
Date of Patent:
April 11, 2023
Assignee:
University of Maryland, Baltimore
Inventors:
Joseph Pao Yung Kao, Christopher William Ward, Ramzi Khairallah
Abstract: This invention is a computer-implemented method and system of using a secondary classification algorithm after using a primary source code vulnerability scanning tool to more accurately label true and false vulnerabilities in source code. The method and system use machine learning within a 10% dataset to develop a classifier model algorithm. A selection process identifies the most important features utilized in the algorithm to detect and distinguish the true and false positive findings of the static code analysis results. A personal identifier is used as a critical feature for the classification. The model is validated by experimentation and comparison against thirteen existing classifiers.
Type:
Grant
Filed:
June 24, 2020
Date of Patent:
April 4, 2023
Assignee:
UNIVERSITY OF MARYLAND BALTIMORE COUNTY
Inventors:
George Karabatis, Foteini Cheirdari-Argiropoulos