Abstract: Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.
Type:
Grant
Filed:
May 28, 2021
Date of Patent:
September 24, 2024
Assignee:
University of Marylnd, College Park
Inventors:
Daniel R. Perez, Hongjun Chen, Yibin Cai, Lindomar Jose Pena, Matthew Angel
Abstract: Solid electrolytes compositions, methods of making the solid electrolytes, and methods of using the solid electrolytes in batteries and other electrochemical technologies are disclosed. The method of producing a solid electrolyte comprises (a) ball milling Na2CO3, SiO2, NH4H2PO4, a zirconium source, and a dopant to produce a ball milled powder; (b) calcining the ball milled powder to produce a calcined powder; and (c) sintering the calcined powder to produce a solid electrolyte. The zirconium source for the solid electrolyte may be ZrO2. The dopant for the solid electrolyte may be AI2O3, Fe2O3, Sb2O3, Yb2O3, or Dy2O3.
Type:
Application
Filed:
September 25, 2013
Publication date:
September 3, 2015
Applicant:
University of Marylnd, College Park
Inventors:
Eric D. Wachsman, Gregory Thomas Hitz, Kang Taek Lee