Patents Assigned to University of Massachusettes
  • DCAS13-MEDIATED THERAPEUTIC RNA BASE EDITING FOR IN VIVO GENE THERAPY
    Publication number: 20230346978
    Abstract: Aspects of the disclosure relate to compositions (e.g., isolated nucleic acids, rAAV vectors, rAAVs, etc.) and methods for gene editing. The disclosure is based, in part, on isolated nucleic acids encoding combinations of gene editing proteins (e.g., Cas proteins) and base editors (e.g., Adenosine Deaminase Acting on RNA deaminase domains) with certain regulatory sequences that are amenable to packaging in recombinant adeno-associated viruses (rAAVs). In some embodiments, compositions described by the disclosure are useful for treating certain diseases in a subject in need thereof.
    Type: Application
    Filed: April 13, 2021
    Publication date: November 2, 2023
    Applicant: University of Massachusetts
    Inventors: Dan Wang, Guangping Gao, Jiaming Wang
  • ADENO-ASSOCIATED VIRUS FOR DELIVERY OF KH902 (CONBERCEPT) AND USES THEREOF
    Publication number: 20230340529
    Abstract: Aspects of the disclosure relate to compositions and methods for expressing anti-Vascular endothelial cell growth factor (VEGF) agent in a cell or subject. In some embodiments, the disclosure provides rAAVs comprising a capsid protein (e.g., AAV2 variants, AAV2/3 hybrid variants, AAV8 variants, etc.), and a transgene encoding an anti-VEGF agent (e.g., KH902) and one or more regulatory sequences. In some embodiments, compositions described herein are useful for treating subjects having diseases associated with angiogenesis or aberrant VEGF activity/signaling.
    Type: Application
    Filed: September 2, 2021
    Publication date: October 26, 2023
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Philip Tai, Claudio Punzo, Haijiang Lin
  • METHOD FOR MATHEMATICAL LANGUAGE PROCESSING VIA TREE EMBEDDINGS
    Publication number: 20230342348
    Abstract: A method for processing formulae includes encoding a formula by: training, with a server, a model by using a machine learning algorithm with a data set that includes a plurality of formulae; transforming, with a processor, a first formula into a tree format using the trained model; converting, with the processor, the tree format of the first formula into a plurality of lists; and encoding, with the processor, the plurality of lists into a fixed dimension vector by leveraging a stacked attention module; and generating one or more formula candidates by: obtaining, with the processor, input information; and generating, with the processor, one or more second formula candidates based on input information by using the stacked attention module with a tree beam search algorithm.
    Type: Application
    Filed: April 21, 2023
    Publication date: October 26, 2023
    Applicants: William Marsh Rice University, University of Massachusetts, Amherst
    Inventors: Zichao Wang, Shiting Lan, Richard G. Baraniuk
  • Brown fat-selective adipokines
    Patent number: 11795201
    Abstract: Methods of treating or reducing the risk of obesity and/or obesity-related disorders, e.g., metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes, using C20orf27 proteins or nucleic acids.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 24, 2023
    Assignee: University of Massachusetts
    Inventors: Yong-Xu Wang, Qingbo Chen
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20230332179
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: November 8, 2022
    Publication date: October 19, 2023
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • USE OF NOVEL MIRNA-BINDING SITE CASSETTES FOR ANTIGEN-PRESENTING CELL DETARGETING OF TRANSGENE EXPRESSION BY RAAV GENE THERAPY
    Publication number: 20230332180
    Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.
    Type: Application
    Filed: April 10, 2023
    Publication date: October 19, 2023
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Phillip Tai, Manish Muhuri, Wei Zhan
  • Genetically modified non-human animals and methods relating to complement dependent cytotoxicity
    Patent number: 11785923
    Abstract: The present invention relates generally to genetically modified non-human animals and immunodeficient non-human animals characterized by restored complement-dependent cytotoxicity, as well as methods and compositions for assessment of therapeutic antibodies in the genetically modified immunodeficient non-human animals. In specific aspects, the present invention relates to immunodeficient non-obese diabetic (NOD), A/J, A/He, AKR, DBA/2, NZB/B1N, B10.D2/oSn and other mouse strains genetically modified to restore complement-dependent cytotoxicity which is lacking in the unmodified immunodeficient mice. In further specific aspects, the present invention relates to NOD.Cg-Prkdcscid IL2retmlWjl/SzJ (NSG), NOD.Cg-Rag1tm1Mom Il2rgtmlWjl/SzJ (NRG) and NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac (NOG) mice genetically modified to restore complement-dependent cytotoxicity which is lacking in unmodified NSG, NRG and NOG mice.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: October 17, 2023
    Assignees: The Jackson Laboratory, University of Massachusetts
    Inventors: Leonard D. Shultz, Mohit Kumar Verma, Dale L. Greiner, Michael A. Brehm
  • A SYSTEM AND METHOD FOR MEMORY ALLOCATION AND MANAGEMENT IN NON-UNIFORM MEMORY ACCESS ARCHITECTURE COMPUTING ENVIRONMENTS
    Publication number: 20230325239
    Abstract: A system and method for memory allocation and management in non-uniform memory access (“NUMA”) architecture computing environments is disclosed. The system and method contemplates both hardware heterogeneity and allocation/deallocation attributes, with fine-grained memory management. NUMAlloc is centered on a binding-based memory management. On top of it, NUMAlloc proposes an “origin-aware memory management” to ensure the locality of memory allocations and deallocations, as well as a method called “incremental sharing” to balance the performance benefits and memory overhead of using transparent huge pages. It further introduced an interleaved heap to reduce the load imbalance among different nodes and an efficient mechanism for object movement. The system and method provides a scalable and increased performance alternative over other prior art memory allocators.
    Type: Application
    Filed: April 11, 2022
    Publication date: October 12, 2023
    Applicant: University of Massachusetts
    Inventors: Tongping Liu, Hanmei Yang, Xin Zhao
  • NSG mice lacking MHC class I and class II
    Patent number: 11778994
    Abstract: A NOD.Cg-PrkdcscidH2rgtm1 Wjl/SzJ.(NOD-scid-IL2r?null, NSG) mouse which is genetically modified such that the en NSG mouse lacks functional major histocompatibility complex I (MHC I) and lacks functional major histocompatibility complex II (MHC II) is provided according to aspects of the present, invention. According to specific aspects the genetically modified NSG mouse, is a NOD.Cg-PrkdcscidH2-K1tml Bpe H2-Ab1eml Mvw H2-D1tml Bpe H2rgtm Wjl/SzJ (NSG-Kb Db)null(IAnull)) mouse, NSG-RIP-DTR (Kb Db)null(IAnull) mouse, or a NOD.Cg-B2mtmlUnePrKdcscidH2dlAb1-E?H2rgtm1 Wjl/SzJ (NSG-B2Mnull(IA IEnull)) mouse. Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: October 10, 2023
    Assignees: The Jackson Laboratory, University of Massachusetts
    Inventors: Michael A. Brehm, Michael V. Wiles, Dale L. Greiner, Leonard D. Shultz
  • Repairing compound heterozygous recessive mutations by allele exchange
    Patent number: 11773410
    Abstract: The disclosure in some aspects relates to methods and compositions for repairing mutations (e.g., compound heterozygous mutations) that are widely found in patients having certain diseases (e.g., monogenic recessive diseases). In some aspects, the disclosure provides a method for targeted allelic exchange using recombinant gene editing complex.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: October 3, 2023
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Dan Wang
  • AAV treatment of Huntington's disease
    Patent number: 11773392
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: October 3, 2023
    Assignee: University of Massachusetts
    Inventors: Christian Mueller, Neil Aronin, Edith L. Pfister
  • Viral vector production
    Patent number: 11767539
    Abstract: In some aspects, the disclosure relates to methods for improving titer and yield of viral vector production. In some embodiments, the methods comprise transient silencing of transgene expression during packaging of a viral vector.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 26, 2023
    Assignee: University of Massachusetts
    Inventors: Jun Xie, Guangping Gao
  • GENE THERAPEUTICS FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
    Publication number: 20230295662
    Abstract: In some aspects, the disclosure relates to compositions and methods for treating fibrodysplasia ossificans progressiva (FOP) in a subject. In some aspects, the disclosure provides isolated nucleic acids, and vectors such as rAAV vectors, configured to express transgenes that inhibit (e.g., decrease) expression of mutated AVCR1 gene in muscle cells or connective tissues.
    Type: Application
    Filed: April 21, 2023
    Publication date: September 21, 2023
    Applicant: University of Massachusetts
    Inventors: Jae-Hyuck Shim, Guangping Gao, Jun Xie, Yeon-Suk Yang, Jung min Kim, Sachin Chaugule
  • RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
    Patent number: 11760999
    Abstract: The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: September 19, 2023
    Assignee: University of Massachusetts
    Inventors: Christian Mueller, Robert H. Brown, Jr.
  • DNA-BINDING DOMAIN TRANSACTIVATORS AND USES THEREOF
    Publication number: 20230279405
    Abstract: In some aspects, the disclosure relates to recombinant adeno-associated viruses (rAAVs) comprising a nucleic acid encoding a fusion protein comprising a DNA-binding domain and a transcriptional regulator domain and methods of using the same. In some embodiments, expression of the fusion protein results in modified expression of a target gene in a cell.
    Type: Application
    Filed: July 23, 2021
    Publication date: September 7, 2023
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Scot A. Wolfe
  • Protein-polymer nanoassemblies and intracellular protein delivery
    Patent number: 11746172
    Abstract: The invention provides novel polymer-protein conjugates and molecular assemblies for controlled intracellular delivery of proteins, and compositions and methods of preparation and use thereof.
    Type: Grant
    Filed: July 19, 2020
    Date of Patent: September 5, 2023
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Bin Liu
  • Minigene therapy
    Patent number: 11739346
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: August 29, 2023
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Hemant Khanna
  • SOD1 dual expression vectors and uses thereof
    Patent number: 11739330
    Abstract: In some aspects, the disclosure relates to compositions and methods useful for inhibiting SOD1 expression in cells (e.g., cells of a subject). In some embodiments, the disclosure describes isolated nucleic acids engineered to express an inhibitory nucleic acid targeting endogenous SOD1 and an mRNA encoding a hardened SOD1 protein. In some embodiments, compositions and methods described by the disclosure are useful for treating Amyotrophic Lateral Sclerosis (ALS) in a subject.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: August 29, 2023
    Assignee: University of Massachusetts
    Inventors: Christian Mueller, Robert H. Brown
  • Anti-ETEC adhesin protein antibodies and methods of use
    Patent number: 11732032
    Abstract: The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: August 22, 2023
    Assignee: University of Massachusetts
    Inventors: Mark S. Klempner, Yang Wang, Lisa Cavacini, Alla Amcheslavsky
  • SILENCING OF DUX4 BY RECOMBINANT GENE EDITING COMPLEXES
    Publication number: 20230250407
    Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy. FSHD).
    Type: Application
    Filed: December 13, 2022
    Publication date: August 10, 2023
    Applicant: University of Massachusetts
    Inventors: Peter L. Jones, Charis L. Himeda, Takako Jones