Patents Assigned to University of Massachusetts
  • Patent number: 11126403
    Abstract: A true random number generator device based on a diffusive memristor is disclosed. The random number generator device includes a diffusive memristor driven by a pulse generator circuit. The diffusive memristor produces a stochastically switched output signal. A comparator circuit receives the stochastically switched output signal from the diffusive memristor and generates an output signal having a random pulse width. An AND gate logic circuit is driven by a clock signal and the output signal from the comparator circuit. The AND gate logic circuit produces a combined output signal. A counter circuit receives the combined output signal from the AND gate logic circuit and generates a random bit string output signal.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: September 21, 2021
    Assignee: University of Massachusetts
    Inventors: Jianhua Yang, Qiangfei Xia, Hao Jiang
  • Patent number: 11124795
    Abstract: Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: September 21, 2021
    Assignee: University of Massachusetts
    Inventors: Michael R. Green, Minggang Fang
  • Patent number: 11120348
    Abstract: The present invention relates generally to identifying relationships between items. Certain embodiments of the present invention are configurable to identify the probability that a certain event will occur by identifying relationships between items. Certain embodiments of the present invention provide an improved supervised machine learning system.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: September 14, 2021
    Assignee: University of Massachusetts
    Inventor: Hong Yu
  • Patent number: 11116851
    Abstract: The invention relates to the discovery of a vital new component of the Wnt pathway that regulates trafficking of ?-catenin to the cell nucleus and novel therapeutic approaches to cancer treatment. Disclosed herein is a previously unknown, essential component of the Wnt/?-catenin signaling pathway that governs the quantity of ?-catenin delivered to the cell nucleus. This intracellular inhibitor of ?-catenin signaling (IBS) is transcribed from a second transcriptional start site adjacent to exon 3 of the Dkk3 gene and is required for early mouse development. IBS captures ?-catenin destined for the nucleus in a complex with ?-TrCP that is bound to the actin cytoskeleton and unavailable for nuclear translocation.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: September 14, 2021
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Karl J. Simin, Deborah M. Leonard
  • Patent number: 11120688
    Abstract: Traversing, by an autonomous vehicle, a vehicle transportation network, may include identifying a policy for a scenario-specific operational control evaluation model of a distinct vehicle operational scenario, receiving a candidate vehicle control action from the policy, wherein, in response to a determination that an uncertainty value for the distinct vehicle operational scenario exceeds a defined uncertainty threshold, the candidate vehicle control action is an orientation-adjust vehicle control action, and traversing a portion of the vehicle transportation network in accordance with the candidate vehicle control action, wherein the portion of the vehicle transportation network includes the distinct vehicle operational scenario.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 14, 2021
    Assignees: Nissan North America, Inc., The University of Massachusetts
    Inventors: Kyle Hollins Wray, Stefan Witwicki, Shlomo Zilberstein, Melissa Cefkin
  • Patent number: 11111275
    Abstract: The present invention provides compositions and methods for using prophylactic and/or therapeutic vaccines to immunize subjects, and offspring of immunized female subjects, against respiratory syncytial virus (RSV). The invention also provides compositions and methods for producing increased yields of recombinant virus-like particles (VLPs).
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: September 7, 2021
    Assignee: The University of Massachusetts
    Inventor: Trudy Gilkerson Morrison
  • Patent number: 11110941
    Abstract: Centralized shared scenario-specific operational control management includes receiving, at a centralized shared scenario-specific operational control management device, shared scenario-specific operational control management input data, from an autonomous vehicle, validating the shared scenario-specific operational control management input data, identifying a current distinct vehicle operational scenario based on the shared scenario-specific operational control management input data, generating shared scenario-specific operational control management output data based on the current distinct vehicle operational scenario, and transmitting the shared scenario-specific operational control management output data.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: September 7, 2021
    Assignees: Renault S.A.S., Nissan North America, Inc., The University of Massachusetts
    Inventors: Kyle Hollins Wray, Stefan Witwicki, Shlomo Zilberstein
  • Patent number: 11113973
    Abstract: Autonomous vehicle operational management including blocking monitoring may include traversing, by an autonomous vehicle, a vehicle transportation network. Traversing the vehicle transportation network may include operating a blocking monitor instance, which may include identifying operational environment information including information corresponding to a first external object within a defined distance of the autonomous vehicle, determining a first area of the vehicle transportation network based on a current geospatial location of the autonomous vehicle in the vehicle transportation network and an identified route for the autonomous vehicle, and determining a probability of availability for the first area based on the operational environment information. Traversing the vehicle transportation network may include traversing a portion of the vehicle transportation network based on the probability of availability.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 7, 2021
    Assignees: Nissan North America, Inc., The University of Massachusetts
    Inventors: Kyle Wray, Stefan Witwicki, Shlomo Zilberstein, Liam Pedersen
  • Patent number: 11107610
    Abstract: A method includes blending a dielectric material including a titanate with a carbon-based ink to form a modified carbon-based ink. The method also includes printing the modified carbon-based ink onto a structure. The method further includes curing the printed modified carbon-based ink on the structure at a temperature that does not exceed about 250° C. In addition, the method includes processing the cured printed modified carbon-based ink to form a thick film resistor. Blending the dielectric material with the carbon-based ink causes the modified carbon-based ink to have a resistivity that is at least double a resistivity of the carbon-based ink.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: August 31, 2021
    Assignees: Raytheon Company, University of Massachusetts
    Inventors: Erika C. Klek, Mary K. Herndon, Thomas V. Sikina, James E. Benedict, Andrew R. Southworth, Kevin M. Wilder, Oshadha K. Ranasingha, Alkim Akyurtlu
  • Patent number: 11103538
    Abstract: One embodiment provides an attenuated Salmonella strain comprising a lysis gene or cassette operably linked to an intracellularly induced Salmonella promoter. In one embodiment, the promoter is a promoter for one of the genes in Salmonella pathogenicity island 2 type III secretion system (SPI2-T3SS) selected from the group SpiC/SsaB, SseF, SseG, SseI, SseJ, SseK1, SseK2, SifA, SifB, PipB, PipB2, SopD2, GogB, SseL, SteC, SspH1, SspH2, or SirP. In one embodiment, a Salmonella gene is under the regulation of an inducible promoter, wherein the gene is selected from ftsW, ftsA, ftsZ, murE, mukF, imp, secF, eno, hemH, tmk, dxs, uppS, cdsA, accA, pssA, msbA, tsf, trmD, cca, infB, rpoA, rpoB, rpoC, holA, dnaC, or eng. In one embodiment, the Salmonella strain further comprises a plasmid that expresses DNA, shRNA, non-coding RNA and/or a peptide.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 31, 2021
    Assignee: University of Massachusetts
    Inventors: Neil S. Forbes, Nele Van Dessel
  • Publication number: 20210261982
    Abstract: Aspects of the disclosure relate to integration of a transgene packaged into recombinant adeno-associated virus (rAAV) by nuclease-assisted vector integration (NAVI).
    Type: Application
    Filed: April 29, 2019
    Publication date: August 26, 2021
    Applicant: University of Massachusetts
    Inventors: Alexander Brown, Guangping Gao
  • Patent number: 11098043
    Abstract: This disclosure relates to compounds that are CBP inhibitor and methods of using such compounds in the treatment and diagnosis of diseases and disorders.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: August 24, 2021
    Assignee: University of Massachusetts
    Inventors: Wei Zhang, Alex Mugwiria Muthengi, Hailemichael O. Yosief
  • Patent number: 11091789
    Abstract: There is provided a renewable sensor for sensing or selectively capturing a targeted bacteria in a fluid. The renewable sensor includes a surface, the surface includes a substrate, a biologically or bacterially non-adhesive feature disposed on or in functional proximity to at least a portion of the substrate; and an adhesive elements disposed on or in functional proximity to the non-adhesive feature, a flow channel in operative contact with the surface; and a detector configured to detect the targeted cell type captured on the surface. Also provided are method for using the sensor and the surface.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: August 17, 2021
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Maria Santore, Bing Fang
  • Patent number: 11090305
    Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: August 17, 2021
    Assignee: University of Massachusetts
    Inventor: Louis M. Messina
  • Patent number: 11094473
    Abstract: The invention provides an all-day solar cell system that is capable of simultaneously generating and storing electricity, which allows efficient photocharge during the day and discharge at night.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: August 17, 2021
    Assignee: University of Massachusetts
    Inventors: Fuqiang Liu, Zi Wei, Husain Almakrami
  • Publication number: 20210246443
    Abstract: The relates, in some aspects, to antisense oligonucleotide compositions and methods for modifying pre-mRNA splicing in a DYSF gene using the same. In some embodiments, the DYSF gene comprises a novel mutation that results in a pseudoexon between exons 50 and 51.
    Type: Application
    Filed: June 7, 2019
    Publication date: August 12, 2021
    Applicant: University of Massachusetts
    Inventors: Robert H. Brown, JR., Janice A. Dominov
  • Publication number: 20210246450
    Abstract: The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.
    Type: Application
    Filed: February 12, 2021
    Publication date: August 12, 2021
    Applicant: University of Massachusetts
    Inventors: Christian Mueller, Robert H. Brown, JR.
  • Patent number: 11084504
    Abstract: Traversing, by an autonomous vehicle, a vehicle transportation network, may include operating a scenario-specific operational control evaluation module instance, wherein the scenario-specific operational control evaluation module instance includes an instance of a scenario-specific operational control evaluation model of a vehicle operational scenario wherein the vehicle operational scenario is a merge vehicle operational scenario or a pass-obstruction vehicle operational scenario, receiving a candidate vehicle control action from the scenario-specific operational control evaluation module instance, and traversing a portion of the vehicle transportation network in accordance with the candidate vehicle control action.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: August 10, 2021
    Assignees: Nissan North America, Inc., The University of Massachusetts, Renault S.A.S.
    Inventors: Kyle Hollins Wray, Stefan Witwicki, Shlomo Zilberstein
  • Patent number: 11083631
    Abstract: The present invention relates to a negative pressure wound closure system and methods for using such a system. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Preferred embodiments can utilize tissue grasping elements to apply a wound closing force to the tissue.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: August 10, 2021
    Assignees: University of Massachusetts, Smith & Nephew, Inc.
    Inventors: Raymond M. Dunn, Victoria Jody Hammond, Edward Yerbury Hartwell, John Kenneth Hicks, Elizabeth Mary Huddleston, Andrew Kelly, Andrew Linton, Mark Richardson, Carl Saxby, Tim Stern
  • Publication number: 20210238233
    Abstract: The disclosure relates, in some aspects, to adeno-associated vims capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 5, 2021
    Applicants: University of Massachusetts, The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury, Kathryn Rae Wagner, Jennifer Gifford Green, Ana Rita Batista