Patents Assigned to University of Massachusetts
  • Patent number: 11981892
    Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: May 14, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer
  • Patent number: 11982637
    Abstract: A gas sensor includes a biomaterial comprising electrically-conductive protein nanowires and at least two electrodes. The at least two electrodes are in operative arrangement with the protein nanowires and configured to provide a signal indicative of a change in conductivity of the protein nanowires. The conductivity of the protein nanowires is responsive to a change in concentration of a gas exposed to the biomaterial, such as ammonia, or to a change in relative humidity.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: May 14, 2024
    Assignee: University of Massachusetts
    Inventors: Jun Yao, Derek R. Lovley, Alexander Smith, Xiaomeng Liu
  • Publication number: 20240139340
    Abstract: The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.
    Type: Application
    Filed: October 20, 2023
    Publication date: May 2, 2024
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Ana Rita Batista, Sourav Roy Choudhury
  • Patent number: 11963975
    Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: April 23, 2024
    Assignee: University of Massachusetts
    Inventors: Peter L. Jones, Michael R. Green
  • Patent number: 11964920
    Abstract: Various embodiments disclosed relate to a method of forming a composite including a carbon composite structure. The method includes disposing a precursor composition on a substrate. The composition includes a porogen component, a carbon component, and a catalyst component. The method further includes irradiating the precursor composition to form the carbon composite structure.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: April 23, 2024
    Assignee: University of Massachusetts
    Inventors: James J. Watkins, Dong-Po Song, Wenhao Li
  • Publication number: 20240123086
    Abstract: Aspects of the disclosure relate to compositions and methods for epigenetic regulation of endogenous gene expression from viral vectors. In some embodiments, the disclosure provides expression constructs comprising a viral vector encoding a transgene, the activation of which is regulated by a rapamycin/rapalog-based system, and the transgene is capable of epigenetically regulate an endogenous gene.
    Type: Application
    Filed: February 24, 2022
    Publication date: April 18, 2024
    Applicant: University of Massachusetts
    Inventor: Christian Mueller
  • Patent number: 11961628
    Abstract: Aspects relate to patterned nanostructures having a feature size not including film thickness of below 5 microns. The patterned nanostructures are made up of nanoparticles having an average particle size of less than 100 nm. A nanoparticle composition, which, in some cases, includes a binder, is applied to a substrate. A patterned mold used in concert with electromagnetic radiation function to manipulate the nanoparticle composition in forming the patterned nanostructure. In some embodiments, the patterned mold nanoimprints a pattern onto the nanoparticle composition and the composition is cured through UV or thermal energy. Three-dimensional patterned nanostructures may be formed. A number of patterned nanostructure layers may be prepared and joined together. In some cases, a patterned nanostructure may be formed as a layer that is releasable from the substrate upon which it is initially formed.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: April 16, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: James Watkins, Michael R. Beaulieu, Nicholas R. Hendricks
  • Patent number: 11953584
    Abstract: System, computer products, and methods can improve the resolution of data from a sensor array. One of these methods include receiving, from an analog to digital converter, a series of measurements representing frequency samples and spatial samples from a sensor array. The method includes generating a plurality of factors based on a polynomial. The method includes applying one or more complex weights to the measurements based on the factors. The method includes combining the complex weighted measurements into a plurality of values. The method also includes identifying a characteristic of an object detected by the sensor array based on the plurality of values.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: April 9, 2024
    Assignee: University of Massachusetts
    Inventors: Dayalan P. Kasilingam, Matthew J. Curtis, Murilo Souza Silva, Jr.
  • Patent number: 11944450
    Abstract: Many treatments of skin cancer need an accurate assessment of the margins of the tumor. Spectrally-encoded optical polarization imaging improves upon the demarcation of skin cancer such as keratinocytic carcinomas. When the clinician can outline the clinical boundary of each lesion, surgery and other treatments can be more efficient and effective. Optical images of the lesions are acquired at various wavelengths, then spectrally-encoded. Spectral-encoding of the images minimizes the impact of background pigmentation and vascularization so that the tumor can be accurately visualized.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: April 2, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventor: Anna N. Yaroslavsky
  • Patent number: 11945441
    Abstract: Providing explanations in route planning includes determining a route based on at least two objectives received from a user, where a second objective of the at least two objectives is constrained to within a slack value of a first objective of the at least two objectives; receiving, from the user, a request for an explanation as to an action along the route; and providing the explanation to the user. The explanation describes an extent of violating the slack value.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: April 2, 2024
    Assignees: Nissan North America, Inc., The University of Massachusetts
    Inventors: Kyle Hollins Wray, Stefan Witwicki, Shlomo Zilberstein
  • Publication number: 20240098887
    Abstract: A flexible circuit module is disclosed. The flexible circuit module includes a fabric member including a plurality of fibers having non-conductive elements, and conductive elements oriented through the plane of the fabric. Each conductive element includes a first fiber element strand and a first unterminated end opposite the first fiber element strand, and a second fiber element strand having second unterminated end opposite the second fiber element strand. The fabric member further includes a first side with the first fiber element strands extending therefrom and a second side with second fiber element strands extending therefrom. A first hook-and-loop busbar is conductively connected to the first fiber element strands and a second hook-and-loop busbar is conductively connected to the second fiber element strands.
    Type: Application
    Filed: March 31, 2023
    Publication date: March 21, 2024
    Applicants: University of Massachusetts, U.S. Government
    Inventors: Ramaswamy NAGARAJAN, Jayant KUMAR, Ravi MOSURKAL, Siddhant IYER, Claire LEPONT, Lian LI
  • Patent number: 11931352
    Abstract: This invention relates to methods and compositions for treatment of inv (16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv (16) leukemia comprising the step of administering to a subject in in need thereof a therapeutically effective combination of a) a compound of the formula (1) (1) and b) a BRD4 inhibitor selected from the group consisting of JQ1, CeMMECZ, 1-BET 151 (or GSK1210151A), 1-BET 762 (or GSK525762), PFI-1, bromosporine, OTX-015 (or MK-8628), TEN-010, CPI-203, CPI-0610, RVX-208, BI2536, TG101348, LY294002, ABBV-075 (or mivebresib), FT-1101, ZEN003694, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv (16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the BRD4 inhibitor and a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: March 19, 2024
    Assignees: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, UNIVERSITY OF MASSACHUSETTS
    Inventors: John H. Bushweller, Anuradha Illendula, Lucio Hernan Castilla, John Anto Pulikkan
  • Patent number: 11932599
    Abstract: Provided is a compound according to Formula 1 wherein X, R, R1, R2, R3, and R4 are as defined herein. The compound of Formula 1 can be useful in a composition and in a method for inducing ferroptosis in a cell.
    Type: Grant
    Filed: March 23, 2022
    Date of Patent: March 19, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Rachid Skouta, Thomas K. Dawson, Rohit Bhadoria
  • Patent number: 11931159
    Abstract: A textile-based hydrogel electrode comprises a textile-based backing layer, a conductive structure coupled to the textile-based backing layer, and a hydrogel body in contact with at least a first portion of the conductive structure, wherein the first portion of the conductive structure and the hydrogel body form an ionic interface configured to generate an electrical signal through the conductive structure corresponding to a biopotential change proximate to the textile-based hydrogel electrode.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: March 19, 2024
    Assignee: University of Massachusetts
    Inventors: Seyedeh Zohreh Homayounfar, Ali Kiaghadi, Soha Rostaminia, Deepak Ganesan, Trisha L. Andrew
  • Patent number: 11932848
    Abstract: The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: March 19, 2024
    Assignee: University of Massachusetts
    Inventors: Job Dekker, Josee Dostie
  • Publication number: 20240084303
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (111 1) and methods of treating Huntington's disease using the same.
    Type: Application
    Filed: August 17, 2023
    Publication date: March 14, 2024
    Applicant: University of Massachusetts
    Inventors: Christian Mueller, Neil Aronin, Edith L. Pfister
  • Patent number: 11926842
    Abstract: In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: March 12, 2024
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Phillip Tai, Elisabet C. Mandon, Jianzhong Ai
  • Patent number: 11926933
    Abstract: The disclosure relates to a method of making carbon fiber, the method comprising pyrolyzing poly(p-phenylene) (PPP) fiber at a temperature sufficient to convert PPP fiber substantially to carbon fiber. The disclosure also relates to pre-PPP polymer, methods for making PPP fiber from pre-PPP polymer and, in turn, making carbon fiber from PPP fiber.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: March 12, 2024
    Assignee: University of Massachusetts
    Inventors: Nese Orbey, Carl W. Lawton, Burcin Ikizer
  • Publication number: 20240076692
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same.
    Type: Application
    Filed: June 30, 2023
    Publication date: March 7, 2024
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hemant Khanna
  • Patent number: 11920135
    Abstract: Methods and compositions for treating cancer, e.g., prostate cancer, using a combination of P-Rex1 or Rac1 inhibitors and VEGF/VEGFR-targeted therapy.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: March 5, 2024
    Assignee: University of Massachusetts
    Inventors: Hira Lal Goel, Arthur M. Mercurio