Patents Assigned to University of Massachusetts
  • Patent number: 11453746
    Abstract: The invention relates to compositions of co-polymers having hydrophilic and biodegradable hydrophobic units or blocks, resulting in improved properties and functionalities suitable for biomedical applications as self-fitting tissue scaffolds or minimally invasive surgical implants.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: September 27, 2022
    Assignee: University of Massachusetts
    Inventors: Jie Song, Ben Zhang
  • Patent number: 11453864
    Abstract: Many strains of the human pathogen Neisseria meningitidis carry a compact Cas9 (NmeCas9) that can serve to limit genetic exchange via natural transformation. Cas9 orthologues (including NmeCas9) have recently been adopted for RNA-guided genome engineering and DNA binding, adding to the need to define better their activities and properties. The present invention examines DNA cleavage activities and substrate requirements of NmeCas9, including a set of unusually complex PAM recognition patterns. Unexpectedly, NmeCas9 is found able to cleave single-stranded DNA (ssDNA) targets in a manner that is RNA-guided but both PAM- and tracrRNA-independent. Beyond the requirement for guide-target pairing, this activity has no apparent sequence requirements, and the cleavage sites are measured from the 5? end of the DNA substrate's RNA-paired region.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: September 27, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Erik J. Sontheimer, Yan Zhang
  • Patent number: 11445976
    Abstract: A garment system comprises a garment substrate formed from one or more textile-based sheets, a distributed array of a plurality of resistive pressure sensors coupled to the garment substrate at a set of first specified locations. Each of the plurality of resistive sensors comprises a pair of first textile-based outer layers each having an electrical resistance of no more than 100 ohms and a textile-based inner layer sandwiched between the pair of first textile-based outer layers having an electrical resistance of at least 1 mega-ohm. The system also includes electronics configured to process signals from the distributed array of resistive pressure sensors to determine one or more physiological properties of a wearer of the garment substrate.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: September 20, 2022
    Assignee: University of Massachusetts
    Inventors: Deepak Ganesan, Trisha L. Andrew, Ali Kiaghadi, Seyedeh Zohreh Homayounfar, Jeremy Gummeson
  • Patent number: 11439539
    Abstract: The present invention relates to wound closure devices, systems and methods. Embodiments of the invention facilitate closure of the wound by preferentially contracting under negative pressure to provide for movement of the surrounding tissues. Some embodiments may utilize tissue securing portions that aid in securing the invention within a wound.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: September 13, 2022
    Assignees: University of Massachusetts, Smith & Nephew Inc.
    Inventors: Raymond M. Dunn, Victoria Jody Hammond, Edward Yerbury Hartwell, Marcus Damian Phillips, Mark Richardson, Carl Dean Saxby, Michael Sugrue
  • Patent number: 11440240
    Abstract: Methods and systems for manufacturing re-entrant structures, such as the structures exhibiting superomniphobic characteristic, in a continuous, well-controlled, high-rate (mass production, volume) manner are disclosed.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: September 13, 2022
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Joey L. Mead, Carol M. F. Barry, John Shearer, Artee Panwar, Jinde Zhang, Nischay Kodihalli Shivaprakash
  • Publication number: 20220280603
    Abstract: In some aspects, the disclosure relates to compositions and methods useful for the modulating the function of the nuclear pore and/or nucleocytoplasmic transport (NCT). In some embodiments, the disclosure relates to methods of treatment of a neurodegenerative disease (e.g., amyotrophic lateral sclerosis).
    Type: Application
    Filed: August 14, 2020
    Publication date: September 8, 2022
    Applicant: University of Massachusetts
    Inventors: Claudia Fallini, John Landers
  • Publication number: 20220283183
    Abstract: Aspects of the disclosure relate to methods and compositions for diagnosing and/or treating idiopathic Normal Pressure Hydrocephalus (iNPH). In some embodiments, the methods comprise detecting a level of Cwh43 gene expression or Cwh43 protein in a subject and administering to the subject one or more therapies to treat iNPH based upon the level of the Cwh43 gene expression or Cwh43 protein compared to a control sample.
    Type: Application
    Filed: August 12, 2020
    Publication date: September 8, 2022
    Applicant: University of Massachusetts
    Inventor: Mark D. Johnson
  • Patent number: 11434317
    Abstract: The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: September 6, 2022
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Kingshuk Dutta
  • Patent number: 11426469
    Abstract: The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 30, 2022
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Jianzhong Ai, Hong Li, Qiang Wei
  • Patent number: 11421008
    Abstract: The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: August 23, 2022
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Deborah M. Leonard, Karl J. Simin
  • Patent number: 11422091
    Abstract: This invention is in the field of fluorescence imaging and relates to a new near infrared (NIR) reactive oxygen species (ROS) sensor designed with controlled fluorescence on-off switching mechanism.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: August 23, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventor: Maolin Guo
  • Patent number: 11422046
    Abstract: A sensing textile includes at least one assembly of optical fiber filaments, wherein the sensing textile has a main direction and a cross direction, and wherein the at least one assembly of optical fiber filaments is oriented at any angle measured relative to the cross direction.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: August 23, 2022
    Assignees: SAINT-GOBAIN ADFORS CANADA, LTD., UNIVERSITY OF MASSACHUSETTS
    Inventors: Nancy E. Brown, Sahas Rathi, Tzuyang Yu, Xingwei Wang, Pradeep Kurup, Jackson A. Ivey
  • Patent number: 11421993
    Abstract: Aspects and embodiments disclosed herein include a computational approach to automatically generate a wayfinding design for a given environment. To use aspects and embodiments of the disclosed computational approach, a designer specifies all the navigation scenarios likely to be taken by the users. A wayfinding design is then generated to accommodate the needs of all the scenarios while considering a number of desirable factors relevant to the navigation experience and management convenience. Through agent-based simulations, the locations of the wayfinding signs are further refined by considering visibility and robustness with respect to the possible mistakes made by the users throughout their navigation. After generating a wayfinding design, the designer can gain further insights of the design by visualizing the accessibility of a destination from any other locations in the environment and remove any blind zones by adding more signs and re-triggering the optimization.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: August 23, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Lap-Fai Yu, Haikun Huang
  • Patent number: 11419767
    Abstract: Certain embodiments described herein are directed to an elongated layer of material and a lip to be placed in contact with a wound and the elongated layer of material to be wrapped around a wound filler, their methods of use and systems incorporating the same, wherein the wound filler lip is configured to be positioned beneath the fascia. Additionally, some embodiments described herein are directed to the closure of the wound and the use of attachment mechanisms on the elongate layer and lip to attach to the wound surface.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: August 23, 2022
    Assignees: University of Massachusetts, Smith and Nephew, Inc.
    Inventors: Raymond M. Dunn, Edward Yerbury Hartwell, John Kenneth Hicks, Elizabeth Mary Huddleston, Carl Saxby
  • Patent number: 11421230
    Abstract: The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: August 23, 2022
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Phillip D. Zamore, Jun Xie
  • Publication number: 20220259654
    Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
    Type: Application
    Filed: January 27, 2022
    Publication date: August 18, 2022
    Applicant: University of Massachusetts
    Inventors: Michael R. Green, Sanchita Bhatnagar
  • Publication number: 20220257731
    Abstract: In some aspects, the disclosure relates to compositions and methods useful for the diagnosis and treatment of neurodegenerative diseases, such as leukodystrophies (e.g., Canavan Disease). In some embodiments, the methods comprise administering to a subject an N-acetylaspartate (NAA)-depleting agent or an N-acetylaspartate (NAA)-depleting agent based upon the subject's metabolic profile.
    Type: Application
    Filed: January 13, 2022
    Publication date: August 18, 2022
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Dominic Gessler
  • Patent number: 11413356
    Abstract: In some aspects, the disclosure relates to compositions and methods useful for the diagnosis and treatment of diseases associated with a metabolic imbalance in a subject (e.g., cancer). In some embodiments, the methods comprise administering to a subject an N-acetylaspartate (NAA)-depleting agent or an N-acetylaspartate (NAA)-increasing agent based upon the subject's metabolic profile.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: August 16, 2022
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Dominic Gessler
  • Publication number: 20220251602
    Abstract: In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 11, 2022
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Phillip Tai, Elisabet C. Mandon, Jianzhong Ai
  • Patent number: 11401519
    Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: August 2, 2022
    Assignees: UNIVERSITY OF MASSACHUSETTS
    Inventors: Jonathan Watts, Hans Michael Haitchi, Hannah Pendergraff