Patents Assigned to University of Massachusetts
  • Patent number: 10385339
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 20, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. Zamore, Dianne Schwarz
  • Patent number: 10383888
    Abstract: The invention relates to an exopolysaccharide (EPS), compositions comprising EPS and methods of use, including for treating and preventing disorders, such as inflammatory disorders.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: August 20, 2019
    Assignee: University of Massachusetts
    Inventors: Barbara Osborne, Furkan Ayaz, Katherine Knight, Sara Jones
  • Patent number: 10378015
    Abstract: Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and methods of treating HBV infections by targeting those factors. Zinc finger, CCHC domain containing 14 (ZCCHC14) is an exemplary host factor.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: August 13, 2019
    Assignee: University of Massachusetts
    Inventors: Abraham L. Brass, Miles C. Smith
  • Publication number: 20190240353
    Abstract: Methods for treating glaucoma and/or Fas ligand-dependent inflammatory conditions in a subject using soluble Fas ligand (sFasL) or a fragment thereof, which may be rAAV-mediated delivery of sFasL or a fragment thereof to a subject.
    Type: Application
    Filed: July 5, 2017
    Publication date: August 8, 2019
    Applicants: University of Massachusetts, Massachusetts Eye and Ear Infirmary
    Inventors: Ann Marshak-Rothstein, Meredith Gregory-Ksander, Bruce Ksander
  • Patent number: 10369961
    Abstract: Systems and methods for installing retrofit seat belt systems with structural support for the lap and shoulder belts, while at the same time providing a low cost solution. In particular, some, or all of the loads, as required, are shared by an added support structure connected rigidly to a structural base, e.g., of a bus or other vehicle, via a base plate. As such the present teachings achieve compartmentalization around passengers in the event of a crash. Furthermore, unlike prior retrofit seat belt designs, the systems and methods of the present teachings uniquely facilitate a seamless transition for the different seat configurations and do not require complete replacement of the seats.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: August 6, 2019
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Sundar Krishnamurty, Douglas Eddy, Anne Schewe, Conrad Zanzinger
  • Patent number: 10370432
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 6, 2019
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Publication number: 20190233695
    Abstract: An object has a superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of microstructuring microparticles, liquid silane having one or more groups configured to graft to a microstructuring microparticle and at least another group that results in hydrophobicity. The microstructuring microparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting adhesives, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90° and a sliding angle of less than 10° and, less than 5% of an area of the layer is removed in a Tape test.
    Type: Application
    Filed: February 7, 2019
    Publication date: August 1, 2019
    Applicant: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Jason Constantinou, Hanna Dodiuk-Kenig, Carol M. F. Barry, Samuel Kenig, Joey Mead, Artee Panwar, Tehila Nahum
  • Patent number: 10364429
    Abstract: Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: July 30, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. Zamore, Guiliang Tang
  • Patent number: 10358531
    Abstract: The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. The versatilities and advantages of the polymer nanoparticles of the invention include: (i) the guest molecules (e.g.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: July 23, 2019
    Assignee: University of Massachusetts
    Inventor: Sankaran Thayumanavan
  • Patent number: 10358537
    Abstract: Disclosed herein is a composition comprising a polymer; and a superheated fluid; where at least a portion of the polymer and the superheated fluid co-exist in a single phase. Disclosed herein is a method comprising exposing a polymer to a superheated fluid; swelling at least a portion of the polymer with the superheated fluid so that the polymer and the superheated fluid co-exist in a single phase; and changing pressure or temperature within the single phase to change a property in the polymer.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: July 23, 2019
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Alan J. Lesser, Gregory Connor Evans
  • Patent number: 10357049
    Abstract: The use of low energy spontaneous emulsification method to fabricate acidified antimicrobial nanoemulsions suitable for utilization as a food disinfectant/sanitizer is described. The method of these teachings includes pouring an organic phase (containing oil and surfactant and oil-soluble components) into an aqueous phase (containing water and water-soluble components), which leads to the spontaneous formation of fine droplets due to rapid diffusion of the surfactant from the oil phase into the aqueous phase.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: July 23, 2019
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: David J. McClements, Lynne McLandsborough, Kyle Landry
  • Patent number: 10358653
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: July 23, 2019
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Patent number: 10355726
    Abstract: A wideband receiver circuit is disclosed that includes a signal input configured to receive a spectrum signal of bandwidth B that contains an RF signal and an interference signal. A down conversion module is connected to the signal input and has N down conversion channels, wherein each of the N down conversion channels is configured to down convert the spectrum signal to one of N decimated baseband signals by processing the spectrum signal with one distinct phase of a sequence of length N and period N/fclk=N/2B to generate a baseband output signal. An amplifier circuit is connected to each of the N down conversion channels, and is configured to amplify the baseband output signal. A digital signal processing module including an analog to digital conversion circuit is connected to each amplifier circuit and is configured to convert the amplified baseband output signal to N digital signals.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: July 16, 2019
    Assignee: University of Massachusetts
    Inventors: Joseph Bardin, Mohammad Ghadiri-Sadrabadi
  • Patent number: 10350217
    Abstract: Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: July 16, 2019
    Assignees: University of Massachusetts, Worcester Polytechnic Institute
    Inventors: Paul Kaufman, Jessica Lopes Da Rosa-Spiegler, Reeta Prusty Rao, Ahmed Fazly
  • Publication number: 20190211327
    Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).
    Type: Application
    Filed: August 9, 2018
    Publication date: July 11, 2019
    Applicant: University of Massachusetts
    Inventors: Terence Flotte, Christian Mueller, Phillip D. Zamore
  • Patent number: 10344277
    Abstract: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: July 9, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil Aronin, Phillip D. Zamore
  • Patent number: 10336852
    Abstract: A novel amphiphilic graft copolymer is described. A process to make amphiphilic graft copolymers via grafting either poly(ethylene oxide) or polylactide side chains onto an EVA platform using oxo-anion ring-opening polymerization chemistry is also described. Polyethylene or polypropylene based graft copolymers are prepared starting from poly(ethylene-co-vinyl acetate) or maleic anhydride grafted isotactic polypropylene respectively. The amphiphilic character will result from the incorporation of hydrophilic poly(ethylene oxide) (PEO) side-chains. Various applications of the novel amphiphilic graft copolymer are also described including, but not limited to, thermoplastic elastomer, films, fibers, fabrics, gels, breathable packaging materials, additive for biodegradable system, surfactant, antistatic additives, polymer compatibilizers, phase transfer catalysts, solid polymer electrolytes, biocompatible polymers, or incorporation into the materials listed above.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: July 2, 2019
    Assignees: Becton, Dickinson and Company, The University of Massachusetts
    Inventors: Theresa Hermel-Davidock, Edward Bryan Coughlin
  • Patent number: 10337024
    Abstract: A transgenic plant having enhanced photosynthesis is disclosed. The transgenic plant is transformed with a transgenic polynucleotide encoding a heterologous bicarbonate transporter. The bicarbonate transporter can be from an algae or a cyanobacterial species. The transgenic polynucleotide comprises a nucleic acid sequence encoding the bicarbonate transporter under the control of a functional plant promoter and optionally includes a chloroplast envelope targeting peptide heterologous to the bicarbonate transporter. Methods of making the transgenic plant and transgenic polynucleotide are disclosed.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: July 2, 2019
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Danny J. Schnell, Mine O. Canakci, Bibin Paulose, Michelle DaCosta Inguagiato
  • Publication number: 20190194689
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: December 28, 2018
    Publication date: June 27, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • Publication number: 20190194688
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: December 28, 2018
    Publication date: June 27, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu