Patents Assigned to University of Melbourne
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Patent number: 12055489Abstract: A method for characterising a sample located within an imaging region, the method comprising the steps of: generating one or more evanescent fields, each associated with a direction, within the imaging region; capturing an image of the imaging region; determining 5 one or more sample characteristics of the sample according to a spatial intensity pattern resulting from an interaction between the, or each, evanescent field and the sample within the image, and associated apparatus and system.Type: GrantFiled: April 30, 2020Date of Patent: August 6, 2024Assignee: The University of MelbourneInventors: Christopher Graham Bolton, Raymond Riley Dagastine
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Publication number: 20240207034Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.Type: ApplicationFiled: January 24, 2024Publication date: June 27, 2024Applicant: The University of MelbourneInventors: Nicholas Lachlan OPIE, Thomas James OXLEY, Gil Simon RIND, Stephen Michael RONAYNE, Sam Emmanuel JOHN
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Publication number: 20240175958Abstract: For constructing an asymmetric RF pulse for an MRI system, a first RF amplitude for a first part of a time interval is determined and an RF amplitude curve, which depends on at least one RF curve parameter is received. A combined RF amplitude curve for the time interval is determined by combining the first RF amplitude for the first part of the time interval and the RF amplitude curve for a second part of the time interval, which succeeds the first part of the time interval. The combined RF amplitude curve is optimized using a loss function, which comprises an energy loss term, which depends on a pulse energy of the combined RF amplitude curve, and using the at least one RF curve parameter as at least one optimization variable. A combined amplitude of the asymmetric RF pulse is given by the optimized combined RF amplitude curve.Type: ApplicationFiled: November 29, 2023Publication date: May 30, 2024Applicants: Siemens Healthcare GmbH, The University of MelbourneInventors: Jin Jin, Daniel Staeb, Didi Chi, Yasmin Blunck, Leigh Johnston
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Publication number: 20240099825Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.Type: ApplicationFiled: December 4, 2023Publication date: March 28, 2024Applicant: The University of MelbourneInventors: Nicholas Lachlan OPIE, Thomas James OXLEY, Gil Simon RIND, Stephen Michael RONAYNE, Sam Emmanuel JOHN
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Patent number: 11938016Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.Type: GrantFiled: July 30, 2020Date of Patent: March 26, 2024Assignee: The University of MelbourneInventors: Nicholas Lachlan Opie, Thomas James Oxley, Gil Simon Rind, Stephen Michael Ronayne, Sam Emmanuel John
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Publication number: 20240033288Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.Type: ApplicationFiled: June 27, 2023Publication date: February 1, 2024Applicant: The University of MelbourneInventor: Eric Charles Reynolds
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Patent number: 11883671Abstract: Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.Type: GrantFiled: August 10, 2021Date of Patent: January 30, 2024Assignees: Synchron Australia Pty Limited, The University of MelbourneInventors: Nicholas Lachlan Opie, Thomas James Oxley, Gil Simon Rind
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Publication number: 20230404867Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.Type: ApplicationFiled: January 4, 2023Publication date: December 21, 2023Applicant: The University of MelbourneInventor: Eric Charles Reynolds
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Patent number: 11779639Abstract: The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.Type: GrantFiled: May 10, 2019Date of Patent: October 10, 2023Assignees: The Walter and Eliza Hall Institute of Medical Research, The University of MelbourneInventors: Chris Tonkin, Alessandro Uboldi, Malcolm McConville, Martin Blume
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Publication number: 20230302282Abstract: Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.Type: ApplicationFiled: April 28, 2023Publication date: September 28, 2023Applicants: Synchron Australia Pty Limited, The University of MelbourneInventors: Nicholas Lachlan OPIE, Thomas James OXLEY, Gil Simon RIND
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Publication number: 20230263665Abstract: A method of integrating or fusing at least a part of a retina and at least one of a retinal pigmented epithelium (RPE) and choroid underlying the retina and the RPE is disclosed. The method comprises photodehydrating at least some proximal fluid separating one or more of the retina, the RPE and the underlying choroid, with photodehydrating laser light to thereby allow direct contact between the retina and at least one or more of the RPE and choroid. The method further comprises drying at least some of the proximal fluid with a gas flowing at a rate of up to 200 ml/min and photocoagulating with photocoagulating laser light to thereby integrate or fuse at least part of the retina with one or both of the RPE and choroid. Also provided are a device and a system for integrating or fusing these tissues.Type: ApplicationFiled: September 2, 2021Publication date: August 24, 2023Applicants: Centre for Eye Research Australia Limited, The University of Melbourne, Heriot Eyecare Pty. Ltd.Inventors: Wilson J. Heriot, Bang Viet Bui, Andrew Bernard Metha
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Publication number: 20230244091Abstract: Methods and devices to identify contact lens wearers predisposed to contact lens discomfort are described. The methods and devices involve obtaining a tear film sample from a person and determining an amount of interleukin-17A present in the tear film sample.Type: ApplicationFiled: February 27, 2023Publication date: August 3, 2023Applicants: CooperVision International Limited, The University of MelbourneInventors: Laura Elizabeth Downie, David Charles Jackson, Algis Jonas Vingrys, Nancy J. Keir, Inna Maltseva
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Publication number: 20230193389Abstract: The present invention related to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype.Type: ApplicationFiled: October 17, 2022Publication date: June 22, 2023Applicants: ITEK VENTURES PTY LTD, The University of Melbourne, Central Adelaide Local Health Network IncorporatedInventors: Sarah Elizabeth Heron, Leanne Michelle Dibbens, Samuel Frank Berkovic, Ingrid Eileen Scheffer, John Charles Mulley
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Patent number: 11672986Abstract: Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.Type: GrantFiled: April 15, 2022Date of Patent: June 13, 2023Assignees: Synchron Australia Pty Limited, The University of MelbourneInventors: Nicholas Lachlan Opie, Thomas James Oxley, Gil Simon Rind
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Publication number: 20230165979Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a non-small cell lung cancer, small cell carcinoma of the lung, bladder cancer, colon cancer, gallbladder cancer, pancreatic cancer, esophageal cancer, melanoma, liver cancer, primary gastric adenocarcinoma, primary colorectal adenocarcinoma, renal cell carcinoma, prostate cancer, a neuroendocrine tumor, a pituitary tumor, a vasoactive intestinal peptide-secreting tumor, a glioma, breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, and/or a metastatic cancer.Type: ApplicationFiled: April 14, 2021Publication date: June 1, 2023Applicants: Cornell University, The University of MelbourneInventors: John W. BABICH, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Paul Donnelly
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Patent number: 11660168Abstract: A dental implant adapted for implanting within a jaw bone, the implant comprising a horizontally-oriented body having a length extending in the mesial-distal direction of the jaw bone, the body having a threaded cavity dimensioned for receiving a prosthetic abutment, and wherein the cavity comprises an opening that is located wholly within a buccolingual width of the body.Type: GrantFiled: May 6, 2016Date of Patent: May 30, 2023Assignee: The University of MelbourneInventors: Efthimios Gazelakis, Joseph Palamara, Roy Judge
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Publication number: 20230129810Abstract: The invention provides a rotor for a peristaltic pump, the rotor comprising a body for rotation about an axis, the body having a first side and a second side, the body supporting a plurality of spaced first rollers extending from the body on the first side, the first rollers positioned at a first common radius from the axis, the body further supporting a plurality of spaced second rollers extending from the body on the second side, the second rollers positioned at a second common radius from the axis. The invention extends to a peristaltic pumping unit comprising such a rotor assembled with a first stator and a second stator, the first stator having one or more compressible fluid channels arranged to be compressed by said first rollers and the second stator having one or more compressible fluid channels arranged to be compressed by said second rollers.Type: ApplicationFiled: March 11, 2021Publication date: April 27, 2023Applicant: The University of MelbourneInventors: Alastair Stewart, Xumei Gao
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Patent number: 11624740Abstract: A small-sized, portable enclosure protects a gas sensor against degradation due to environmental exposure and changes in atmospheric conditions. The protective enclosure includes an inlet for introduction of a gas into the enclosure, an outlet for release of the gas upon completion of a sensing run, and a number of in-line filters that remove from the inflowing gas sample analytes, contaminants, and other materials that can compromise the integrity of the sensor or cause the sensor to degrade over time. The enclosure does not include any filters during the measurement phase of the sensing run in order to allow the gas sensor to accurately measure an unmodified gas mixture and/or analyte.Type: GrantFiled: July 17, 2020Date of Patent: April 11, 2023Assignees: International Business Machines Corporation, The University of Melbourne, Technische Universiteit EindhovenInventors: Thomas Geoffrey Pattison, Tom Van der Pol, Linda Karin Sundberg, Krystelle Lionti, Andrea Fasoli, Luisa Dominica Bozano
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Publication number: 20230065420Abstract: The present invention relates to methods of diagnosis and therapy for neurodegenerative diseases and disorders.Type: ApplicationFiled: December 11, 2020Publication date: March 2, 2023Applicant: The University of MelbourneInventors: Paul Stephen Donnelly, Katherine Anne Morgan
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Patent number: 11564873Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.Type: GrantFiled: February 5, 2021Date of Patent: January 31, 2023Assignee: The University of MelbourneInventor: Eric Charles Reynolds