Patents Assigned to University of Miami
  • ASSAYS, METHODS AND KITS FOR MEASURING RESPONSE TO THERAPY AND PREDICTING CLINICAL OUTCOME IN PATIENTS WITH B-CELL LYMPHOMA
    Publication number: 20110201008
    Abstract: Assays, methods and kits for predicting survival outcome in a subject having diffuse large B-cell lymphoma (DLBCL) and for measuring a subject's response to DLBCL therapy involve specific miRNAs that are prognostic biomarkers for prediction of outcome of DLBCL patients. Expression of miRNAs miR-18a, miR-181a and miR-222 is associated with response to therapy and outcome of patients with DLBCL. Measurement of these miRs can be used to identify patients' outcomes in the clinic and allow tailoring of patient-specific therapy.
    Type: Application
    Filed: December 1, 2010
    Publication date: August 18, 2011
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Izidore Lossos, Alvero Alencar, Raquel Malumbres, Robert Tibshirani
  • TREATMENT USING CONTINUOUS LOW DOSE APPLICATION OF SUGAR ANALOGS
    Publication number: 20110183926
    Abstract: Methods and uses of low dosage nonmetabolizable D-glucose analogs and mannose analogs such as 2-deoxy-D-glucose, 5-thio-D-glucose, 2-fluoro-2-deoxy-D-glucose, 2-chloro-2-deoxy-D-glucose, 2-bromo-2-deoxy-D-glueose, 2-deoxy-2-fluoro-mannose, 2-deoxy-2-chloro-mannose, 3-deoxy mannose, 4-deoxy mannose, and 2,3 didioxy mannose, for the treatment of tumors.
    Type: Application
    Filed: May 26, 2009
    Publication date: July 28, 2011
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Theodore J. Lampidis, Metin Kurtoglu
  • PORTABLE CARDIO WAVEFORM ACQUISITON AND HEART RATE VARIABILITY (HRV) ANALYSIS
    Publication number: 20110184298
    Abstract: A system and method for measuring heart rate variability (HRV). The system includes at least one biosensor operable to measure at least one signal from the heart. A bioamplifier is also included, the bioamplifier is in communication with the at least one biosensor. The bioamplifier amplifies the at least one signal into at least one amplified analog signal. A portable device is included, the portable device is in communication with the bioamplifier and operable to digitize the at least one amplified signal into one or more digital signals and measure inter-beat intervals from the one or more digital signals and calculate HRV from the measured inter-beat intervals. A database is also included in communication with the portable device, wherein the measured HRV is indexed in the database by one or more criteria.
    Type: Application
    Filed: September 25, 2009
    Publication date: July 28, 2011
    Applicant: University of Miami
    Inventors: Eduardo De Marchena, Suresh Atapattu
  • PEPTIDES THAT ENHANCE ACETYLCHOLINESTERASE EXPRESSION
    Publication number: 20110183922
    Abstract: The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful for enhancing endogenous acetylcholinesterase expression in individuals exposed to organophosphate compounds, such as nerve gases and pesticides.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 28, 2011
    Applicant: University of Miami
    Inventor: Richard L. Rotundo
  • ISOLATION OF STEM CELL PRECURSORS AND EXPANSION IN NON-ADHERENT CONDITIONS
    Publication number: 20110182866
    Abstract: Stem cells and compositions thereof are isolated, cultured and expanded. Culture conditions and methods of culturing the isolated stem cells provide non-adherent stem cells which are prophylactically and therapeutically more effective in patients, diagnostics, screening assays and other stem cell uses.
    Type: Application
    Filed: May 14, 2009
    Publication date: July 28, 2011
    Applicant: UNIVERSITY OF MIAMI
    Inventor: Ian K. Mcniece
  • PINCH MANIFOLD
    Publication number: 20110147411
    Abstract: The present invention includes substance delivery control system having a first conduit defining a lumen for the passage of a substance therethrough; a first delivery control element defining a first conduit state selection element; a second delivery control element defining a second conduit state selection element, where the alignment of the first and second conduit state selection elements places the conduit in a first state, and where misalignment of the first and second conduit state selection elements places the conduit in a second state.
    Type: Application
    Filed: August 12, 2008
    Publication date: June 23, 2011
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Andres Bernal, Faustino Poo
  • CONCURRENT ASSOCIATION OF A WIRELESS MOBILE NODE WITH ACCESS POINTS FOR INCREASING CAPACITY OF ACCESS POINTS
    Publication number: 20110149739
    Abstract: Access for wireless mobile nodes (WMNs) to access points (APs) may be provided via a wireless network where each WMN is associated with a plurality of APs, according to an exemplary embodiment.
    Type: Application
    Filed: August 26, 2009
    Publication date: June 23, 2011
    Applicant: University of Miami Office of Technology Transfer University of Miami School of Medicine
    Inventor: Dilip Sarkar
  • NOVEL GREB1A MONOCLONAL ANTIBODY
    Publication number: 20110123441
    Abstract: The generation and validation of a novel monoclonal GREB1 antibody (GREB1ab). Methods for the prognosis, diagnosis, assessment of disease progression, severity and outcome utilize GREB1 molecules as biomarkers. The GREB1 antibody is also a useful tool for investigations focused on the expression, distribution and function of GREB1 in normal and cancer tissues.
    Type: Application
    Filed: October 20, 2010
    Publication date: May 26, 2011
    Applicants: UNIVERSITY OF MIAMI, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Marc E. Lippman, Harry James Hnatyszyn, Mingli Liu, James M. Rae
  • ANASTOMOSIS SYSTEM AND METHOD
    Publication number: 20110108602
    Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 12, 2011
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: RAMON E. POO, Andreas G. Tzakis
  • Enhanced optical coherence tomography for anatomical mapping
    Patent number: 7924429
    Abstract: A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: April 12, 2011
    Assignee: University of Miami
    Inventors: Robert W. Knighton, Shuliang Jiao, Giovanni Gregori, Carmen A. Puliafito
  • Hybrid device for cell therapies
    Patent number: 7910359
    Abstract: A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: March 22, 2011
    Assignee: University of Miami
    Inventor: Camillo Ricordi
  • AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS
    Publication number: 20110065675
    Abstract: Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC50 values both in a cell-free binding assay and in the inhibition of CD154-induced B-cell proliferation assay. The compounds may be used as therapeutic compounds for treatment of diseases and disorders related to immune or inflammatory responses. Methods of inhibiting the CD40/CD154 protein-protein interaction and treating diseases and disorders related to immune or inflammatory responses are described.
    Type: Application
    Filed: May 5, 2009
    Publication date: March 17, 2011
    Applicant: University of Miami
    Inventors: Peter Buchwald, Emilio Margolles-Clark, Norma S. Kenyon, Camillo Ricordi
  • METHOD FOR TREATING MEIBOMIAN GLAND DISEASE
    Publication number: 20110039805
    Abstract: A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.
    Type: Application
    Filed: July 21, 2010
    Publication date: February 17, 2011
    Applicant: The University of Miami
    Inventors: Stephen C. Pflugfelder, Balakrishna L. Lokeshwar, Marie Selzer
  • COMPOSITIONS, METHODS AND KITS FOR DETECTING AND TREATING CANCER
    Publication number: 20110039788
    Abstract: Compositions, kits and methods for inhibiting cancer cell (e.g., breast cancer cell) growth and treating a subject with cancer (e.g., breast cancer) include a therapeutically effective amount of an LBH inhibitor for inhibiting cancer cell growth and a pharmaceutically acceptable carrier, and/or a therapeutically effective amount of Wnt7a protein or nucleic acids encoding Wnt7a protein for inhibiting cancer cell growth and a pharmaceutically acceptable carrier. Methods of treating a subject having cancer (e.g., estrogen receptor negative basal-type breast cancer) include administering to the subject a composition including a pharmaceutical carrier and at least one of: an LBH inhibitor, a WNT7a protein, and a nucleic acid encoding WNT7a protein in an amount effective for inhibiting growth of cancer cells in the subject. Methods of detecting the presence of cancer (e.g.
    Type: Application
    Filed: July 12, 2010
    Publication date: February 17, 2011
    Applicant: University of Miami
    Inventor: Karoline J. Briegel
  • WASTE RECOVERY COGENERATOR
    Publication number: 20110036320
    Abstract: A waste-to-energy cogeneration system is described in various embodiments. The system can convert certain fuel-laden waste to thermal energy and electrical power. In certain embodiments, fuel-laden waste which has not been pre-filtered or pre-treated to remove particulates and water is deposited in the cogeneration system and prepared by the system for combustion in an unmodified diesel engine. The fuel-laden waste can comprise oils, greases and fats from food preparation which are contaminated with water and particulates. Thermal and mechanical energy produced by the engine are utilized to provide thermal energy and electrical power external to the cogeneration system.
    Type: Application
    Filed: April 3, 2009
    Publication date: February 17, 2011
    Applicant: University of Miami
    Inventor: James Edward Peret
  • ANTIBODY- ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS
    Publication number: 20110038865
    Abstract: Chimeric molecules comprising endostatin and all or a portion of a tumor antigen specific binding molecule for use in treating tumors. The chimeric molecule, includes endostatin, endostatin mutants and variants and an antibody or aptamer specific for a desired tumor antigen. Methods of treating cancer comprise administering the chimeric fusion molecules.
    Type: Application
    Filed: June 26, 2008
    Publication date: February 17, 2011
    Applicant: University of Miami
    Inventors: Seung-Uon Shin, Joseph David Rosenblatt, Sherie L. Morrison
  • METHOD FOR PREPARING RECIPIENT SITE AND IMPLANTING ALLOGENIC BONE GRAFT
    Publication number: 20110034931
    Abstract: A method of fixating allogeneic bone to an area of deficient bone in the jaws comprising: exposing the area of deficient bone by incising and retracting soft tissue; selecting a drill bit having a diameter corresponding to the area of deficient bone to receive donor bone; contacting the selected drill bit with the exposed deficient bone to form a generally cylindrical seat for receiving the donor bone; selecting a section of donor bone having a generally cylindrical shape and circular cross-section corresponding to said formed seat; fixating the donor bone to the formed seat with at least one screw; and closing the soft tissue to cover the previously exposed deficient bone.
    Type: Application
    Filed: February 20, 2009
    Publication date: February 10, 2011
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Yoh Sawatari, Michael Peleg
  • VIRAL RECOMBINEERING AND USES THEREOF
    Publication number: 20110027313
    Abstract: The invention uses recombinant technology to create infectious molecular clones that capture the sequence diversity of viral genes found in natural populations of mixed genotype viruses, such as arises during HIV infections and many other viral diseases. The invention captures the sequence diversity of different genes in these “quasi-species” populations by recombining them into in a constant genetic “backbone” for each viral species by backcrossing PCR products derived from quasispecies gene variants into this backbone in an E. coli BAC plasmid.
    Type: Application
    Filed: April 6, 2009
    Publication date: February 3, 2011
    Applicant: University Of Miami
    Inventors: Rebeca Geffin, Richard Myers
  • PERIFUSION DEVICE
    Publication number: 20110020856
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.
    Type: Application
    Filed: June 30, 2010
    Publication date: January 27, 2011
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: RAMON E. POO, CAMILLO RICORDI, FELIPE ECHEVERRI, Over Cabrera, PER-OLOF BERGGREN
  • Methods and Assays for Detecting and Treating Hypoglycemia
    Publication number: 20110021584
    Abstract: Methods for regulating glucagon release and of treating hypoglycemia, and for screening drug candidates for treating hypoglycemia. The methods are useful for treating diabetes mellitus and screening drug candidates for potential efficacy.
    Type: Application
    Filed: March 12, 2009
    Publication date: January 27, 2011
    Applicant: University of Miami
    Inventors: Per-Olof Berggren, Alejandro Caicedo, Over Cabrera