Abstract: A method of providing an augmented reality game environment within a game space includes obtaining, by a processor, sensor data for the game space, determining, by the processor, a position of a player in the game space based on the sensor data, generating, by the processor, player image data of a peripersonal boundary of the player based on the determined position of the player for rendering a representation of the peripersonal boundary in the game space, the peripersonal boundary being disposed about, and spaced from, the determined position, obtaining, by the processor, player data for the player via an input modality, the player data being indicative of a player directive to modulate the peripersonal boundary, adjusting, by the processor, a size of the peripersonal boundary as a function of the player data, and updating, by the processor, the player image data based on the adjusted size of the peripersonal boundary.

Abstract: A machine vision method includes obtaining a first representation of an image captured by an image sensor array, analyzing the first representation for an assessment of whether the first representation is sufficient to support execution of a machine vision task by the processor, if the first representation is not sufficient, determining, based on the first representation, a region of the image of interest for the execution of the machine vision task, reusing the image captured by the image sensor array to obtain a further representation of the image by directing the image sensor array to sample the image captured by the image sensor array in a manner guided by the determined region of the image of interest and by the assessment, and analyzing the further representation to assess whether the further representation is sufficient to support the execution of the machine vision task by implementing a procedure for the execution of the machine vision task in accordance with the further representation.

Abstract: Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.

Abstract: In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed-even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function.

Abstract: A method and an osseointegrated prosthesis system having an osseointegrated prosthesis member are provided having a monitoring system operably coupled to the osseointegrated prosthesis member configured to quantitatively assess the osseointegration of the osseointegrated prosthesis member, a wave-generating element coupled to the osseointegrated prosthesis member and configured to output guided waves along the osseointegrated prosthesis member interrogating an interface between bone and the osseointegrated prosthesis member, and a sensing system configured to sense a condition of the interface between bone and the prosthesis.

Abstract: Micro-scale thermoelectric devices having high thermal resistance and efficiency for use in cooling and energy harvesting applications and relating fabricating methods are disclosed. The thermoelectric devices include first substrates substantially parallel with second substrates. Scaffold members are deposited between the first and second substrate. The scaffold members include a plurality of cavities having sidewalls. The scaffold members may be formed from the second substrate. The sidewalls are substantially vertical with respect to the second substrate. The sidewalls may be substantially parallel. Thermoelectric materials are deposited on the sidewalls.

Abstract: The present disclosure provides methods of inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins with compositions of Formula (II-A). The methods are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin. Compositions of Formula (II-A) for use in these methods are also provided.

Abstract: The present disclosure provides compositions and methods employing stem cell-derived amnion tissue. In some embodiments, compositions (e.g., scaffolds and devices) and methods of generating amnion-like tissues from hPSCs are provided. In some embodiments, uses of such cells for research, compound screening and analysis, and therapeutics are provided.

Abstract: An uncertainty-aware framework is presented for high-variance planning problems with multiple dynamic agents. Planning when surrounded by multiple uncertain dynamic agents is hard because one cannot be certain of either the initial states or the future actions of those agents, leading to an exponential explosion in possible futures. Many important real-world problems, such as autonomous driving, fit this model. To address these difficulties, Multi-policy Decision Making (MPDM) and Monte Carlo tree search (MCTS) are combined and a policy tree search performed with marginal action cost estimation and repeated belief particles.

Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

Abstract: A system and method for simulating a real roadway environment that can be used for testing of a real connected autonomous vehicle (CAV) on roadways using augmented reality to add simulated virtual environmental objects such as additional vehicles, pedestrians, and other obstructions to the nearby surroundings seen by the CAV under test. The method carried out by the system includes: receiving vehicle status information indicating the location of a connected real vehicle as it moves along a roadway; and generating a simulated environment of the real vehicle on the roadway using a mapped model of the roadway and the vehicle status information. The simulated environment includes one or more virtual objects such as vehicles, pedestrians, or other obstructions, and these simulated virtual objects may be sent to the real vehicle for testing of its response without requiring the use of real vehicles, pedestrians, or other obstructions.

Abstract: Provided are methods for increasing the amount or activity of FMR1 RNA, and in certain instances of increasing the amount of FMRP protein, in an animal Such methods are useful to prevent or ameliorate at least one symptom of a Fragile X-Spectrum disorder. Such Fragile X-Spectrum disorders include FXS, FXTAS, and FXPOI.

Abstract: There is disclosed an electrical device and a method in which a battery is warmed up when operating from a sub-zero temperature. The electrical device may include a battery; an electrical storage element; and a battery management system including a controller in electrical communication with the battery and the electrical storage element. The controller can be configured to execute a program stored in the controller to shuttle energy between the battery and the electrical storage element until a power capability threshold of the battery has been reached, Shuttling the energy raises a temperature of the battery to meet power demand.

Abstract: A microphone including a casing having a front wall, a back wall, and a side wall joining the front wall to the back wall, a transducer mounted to the front wall, the transducer including a substrate and a transducing element, the transducing element having a transducer acoustic compliance dependent on the transducing element dimensions, a back cavity cooperatively defined between the back wall, the side wall, and the transducer, the back cavity having a back cavity acoustic compliance. The transducing element is dimensioned such that the transducing element length matches a predetermined resonant frequency and the transducing element width, thickness, and elasticity produces a transducer acoustic compliance within a given range of the back cavity acoustic compliance.

Abstract: A resonator comprising a magnetoelastic body having a mass load portion and an active resonating portion can be used in implementations such as a security tag. The resonator includes a mass at the mass load portion of the magnetoelastic body. Displacement of the magnetoelastic body is configured to occur at both the mass load portion and the active resonating portion. A strain at the active resonating portion during displacement is configured to be greater than a strain at the mass load portion during displacement.

Abstract: Precise polarimetric imaging of polarization-sensitive nanoparticles is essential to resolving their accurate spatial positions beyond the diffraction limit. However, conventional technologies typically employ mechanically rotated optical components, causing beam deviation errors that cannot be corrected beyond the diffraction limit. To overcome this limitation, a spatially stable nano-imaging system is presented for polarization-sensitive nanoparticles. In this disclosure, it is demonstrated that by integrating a voltage-tunable polarizer into optical microscopy, one is able to achieve high precision nano-imaging without mechanically induced image shift. It is also demonstrated that by integrating a voltage-tunable polarizer into photographic imaging system, one can achieve high-speed suppression of reflection glare and/or high-speed variation light exposure to the imager.

Abstract: The present disclosure provides an imaging system. The imaging system may include a laser cavity that is configured to receive a biological sample, where the biological sample is treated with a dye; an excitation light source that is configured to direct energy at the laser cavity so as to cause an emission from the biological sample, where the emission includes a laser emission at a first spectral band and a fluorescence emission at a second spectral band; a first detector that is configured to measure the laser emission generated by the biological sample; a second detector that is configured to measure the fluorescence emission generated by the biological sample; a splitter that is configured to direct the laser emission to the first detector and the fluorescence emission to the second detector; and a controller interfaced with the excitation light source, the first detector, and the second detector.

Abstract: A computer-implemented method includes preprocessing a variable dimension medical image, identifying one or more areas of interest in the medical image; and analyzing the one or more areas of interest using a deep learning model. A computing system includes one or more processors; and one or more memories storing instructions that, when executed by the one or more processors, cause the computing system to preprocess a variable dimension medical image, identify one or more areas of interest in the medical image; and analyze the one or more areas of interest using a deep learning model. A non-transitory computer readable medium contains program instructions that when executed, cause a computer to preprocess a variable dimension medical image, identify one or more areas of interest in the medical image, and analyze the one or more areas of interest using a deep learning model.

Abstract: Provided herein are systems and methods for performing assays. In particular, provided herein are systems and methods for performing sensitive and rapid immunoassays.