Abstract: A method for blocking mine water inrush includes: grouting first slurry into an interface between the quaternary aquifer and the weathered bedrock aquifer in a fracture grouting manner until a first preset condition is met; forming a first water-resisting cushion after the first slurry is solidified; drilling a curve branch drill hole in the surface horizon downward; grouting second slurry into the curve branch drill hole in a downward grouting manner until a second preset condition is met; forming a second water-resisting cushion after the second slurry is solidified; grouting third slurry onto a top of the first water-resisting cushion in an upward grouting manner until a third preset condition is met; forming a third water-resisting cushion after the third slurry is solidified; wherein the third water-resisting cushion is located on the top of the first water-resisting cushion.