Abstract: This document provides methods and materials related to assessing organisms for the presence or absence of anti-virus antibodies. For example, this document provides methods and materials that can be used to determine whether or not an organism (e.g., a member of a swine species such as a pig) contains anti-PRRS virus antibodies. In other embodiments, this document provides methods and materials that can be used to determine if a particular organism received a vaccine version of a virus, was infected with a naturally-occurring version of the virus, or is naïve with respect to the virus.
Abstract: The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
Abstract: Apparatus and method that includes providing a variable-parameter electrical component in a high-field environment and based on an electrical signal, automatically moving a movable portion of the electrical component in relation to another portion of the electrical component to vary at least one of its parameters. In some embodiments, the moving uses a mechanical movement device (e.g., a linear positioner, rotary motor, or pump). In some embodiments of the method, the electrical component has a variable inductance, capacitance, and/or resistance. Some embodiments include using a computer that controls the moving of the movable portion of the electrical component in order to vary an electrical parameter of the electrical component. Some embodiments include using a feedback signal to provide feedback control in order to adjust and/or maintain the electrical parameter.
Type:
Application
Filed:
October 30, 2012
Publication date:
March 14, 2013
Applicants:
Regents of the University of Minnesota, Life Services, LLC
Inventors:
Life Services, LLC, Regents of the University of Minnesota
Abstract: Novel carbon dioxide-based geothermal energy generation systems, i.e., carbon plume geothermal (CPG) systems, and methods are provided. With the novel systems and methods described herein, geothermal energy can now be provided at lower temperatures and at locations other than hot, dry rock formations, without negatively impacting the surrounding area through use of large-scale hydrofracturing. Use of a carbon dioxide-based geothermal system further provides a means for sequestering and storing excess carbon dioxide, rather than having it released to the atmosphere.
Abstract: Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
Type:
Application
Filed:
September 9, 2011
Publication date:
March 14, 2013
Applicants:
Toyota Motor Engineering & Manufacturing North America, Inc., Regents of the University of Minnesota, Department of Bioproducts & Biosystems Engineering, Toyota Motor Corporation
Abstract: The invention provides compounds of Formula (I) and (IV): as described herein, as well as salts thereof. The compounds have anti-cancer properties and/or chemosensitization properties.
Abstract: A substrate or coating is provided that includes a lipase with enzymatic activity toward a component of a fingerprint. Also provided is a process for facilitating the removal of fingerprints is provided wherein an inventive substrate or coating including a lipase is capable of enzymatically degrading of one or more components of the fingerprint to facilitate fingerprint removal from the substrate or said coating. Applying heat to the substrate or coating increases the rate of fingerprint removal.
Type:
Grant
Filed:
June 21, 2010
Date of Patent:
March 12, 2013
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, Regents of the University of Minnesota
Abstract: A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
Type:
Grant
Filed:
April 15, 2009
Date of Patent:
March 5, 2013
Assignees:
Regents of the University of Minnesota, Medtronic, Inc.
Inventors:
H. Toby Markowitz, Chad Giese, Karl Evan Nowak, Lane A. Phillips
Abstract: There are provided a method, system and medium having instructions embedded to determine an attribute of a simulated patient's state resulting from a patient-physician encounter. The method includes receiving a current treatment move and an initial value of the attribute; calculating a maximal expected incremental effect value of the current treatment move over a previous treatment move on the attribute; attenuating the maximal expected incremental effect value based on amount of time between the previous treatment move and the current treatment move; summing the attenuated maximal expected incremental effect value with the initial value to generate an updated attribute of the simulated patient's state; and generating a patient-physician encounter that includes the updated attribute.
Type:
Grant
Filed:
December 1, 2006
Date of Patent:
March 5, 2013
Assignees:
Regents of the University of Minnesota, HealthPartners Research Foundation
Inventors:
George R. Biltz, Pradyumna Dutta, Paul E. Johnson, Patrick J. O'Connor, William A. Rush, JoAnn M. Sperl-Hillen
Abstract: A method includes applying a pulse train to a spin system in a scanner. The pulse train has a plurality of discontinuities in a time domain. The method includes receiving a response from the spin system. The response corresponds to a gated signal. The method includes accessing a correction factor corresponding to the scanner. The method includes calculating a correction to the response based on the correction factor. The method includes generating an output based on the correction.
Type:
Application
Filed:
June 19, 2012
Publication date:
February 21, 2013
Applicant:
Regents of the University of Minnesota
Inventors:
Curtis A. Corum, Steen Moeller, Djaudat S. Idiyatullin, Ryan Chamberlain, Michael G. Garwood
Abstract: A system comprises an injection well for accessing a reservoir containing a native fluid comprising a hydrocarbon. The reservoir is located below one or more caprocks, is at a first temperature, and is accessible without using large-scale hydrofracturing. The system further includes a production well in fluid communication with the reservoir, a supply apparatus configured to feed a non-water based working fluid at a second temperature that is lower than the first temperature through the injection well to the reservoir. The working fluid mixes with the native fluid to form a production fluid comprising at least a portion of the working fluid and at least a portion of the hydrocarbon at a third temperature that is higher than the second temperature. An energy recovery apparatus in fluid communication with the productions well converts energy contained in the production fluid to electricity, heat, or combinations thereof.
Type:
Application
Filed:
July 20, 2012
Publication date:
February 21, 2013
Applicant:
Regents of the University of Minnesota
Inventors:
Martin O. Saar, Jimmy Bryan Randolph, Thomas H. Kuehn, Kenneth Carpenter
Abstract: An RF coil adjacent an imaging region includes a plurality of conducting coil elements, with each conducting coil element including a proximal portion and a distal portion. The RF coil also includes a capacitance between the distal portions of the at least two conducting coil elements. A mutual coupling inductance between at least two conducting coil elements of the plurality of conducting coil elements is substantially cancelled by the capacitance between the distal portions of the at least two conducting coil elements.
Abstract: A composition comprising a block copolymer that includes at least one polyester block and at least one linear polyolefin block, wherein the composition is in the form of a nano-structured, bicontinuous composite that includes a continuous matrix phase and a second continuous phase. The continuous matrix phase comprises the linear polyolefin block of the block copolymer, and the second continuous phase comprises the polyester block of the block copolymer. The composite may be treated to remove the polyester block, thereby forming a plurality of nano-pores.
Type:
Application
Filed:
March 11, 2011
Publication date:
February 14, 2013
Applicant:
REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventors:
Marc Hillmyer, Louis Pitet, Mark Amendt
Abstract: A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
Abstract: The present invention relates to stable cyanuric acid hydrolase enzymes, compositions, and devices for use in the treatment of a liquid, such as water. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water.
Type:
Grant
Filed:
September 10, 2010
Date of Patent:
February 5, 2013
Assignee:
Regents of the University of Minnesota
Inventors:
Michael J. Sadowsky, Jennifer L. Seffernick, Lawrence P. Wackett
Abstract: An apparatus and method for detecting ionic materials includes a sensing electrode which contacts a liquid sample and detects a sensing voltage corresponding to a surface potential which is changed by a concentration of ionic materials in the liquid sample, a first switching transistor having a first terminal connected to the sensing electrode and a second terminal connected to a first node, a second switching transistor having a first terminal connected to a reset voltage and a second terminal connected to the first node, and a sensing transistor having a gate connected to the first node.
Type:
Grant
Filed:
August 4, 2010
Date of Patent:
February 5, 2013
Assignees:
Samsung Electronics Co., Ltd., Regents of the University of Minnesota
Inventors:
Kyu-tae Yoo, Seong-jin Kim, Eui-sik Yoon
Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.
Type:
Application
Filed:
August 20, 2012
Publication date:
January 31, 2013
Applicant:
Regents of the University of Minnesota
Inventors:
Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
Abstract: A process for stabilizing a bioactive composition includes forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores while keeping the protein molecules biologically active.
Type:
Grant
Filed:
June 18, 2012
Date of Patent:
January 29, 2013
Assignees:
Regents of the University of Minnesota, Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation