Patents Assigned to University of N.C. at Chapel Hill
  • Time release delivery system
    Patent number: 6004572
    Abstract: A system to deliver a treating agent of interest to a surrounding environment over an extended period of time is described. The system comprises surrounding a treating agent or agents with one or more biodegradable materials. The biodegradable materials biodegrade at a rate that will slowly and continuously release the treating agent or agents of interest to the surrounding environment. An example of the method of the present invention is described for the treatment of wood supporting structures to prevent their decay and rotting in the earth. The method is particularly advantageous for treating wood supporting structures including, but not limited to: telephone poles, utility poles, pilings, railroad ties, posts, foundations and other building supports and the like.
    Type: Grant
    Filed: January 25, 1996
    Date of Patent: December 21, 1999
    Assignees: Triangle Laboratories, Inc., University of N.C. - Chapel Hill
    Inventors: Donald J. Harvan, Frederic K. Pfaender
  • Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines
    Patent number: 5679684
    Abstract: Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 21, 1997
    Assignees: Macronex, Inc., The University of N.C. at Chapel Hill
    Inventors: Bradley J. Benson, Xiannong Chen, George J. Cianciolo, Jose-Luis Diaz, Khalid S. Ishaq, Susan L. Morris-Natschke, Ronald J. Uhing, Henry Wong
  • Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
    Patent number: 5177198
    Abstract: A process of making oligoribonucleoside and deoxyribonucleoside boranophosphates and salts thereof is disclosed. The process comprises the steps of condensing a ribonucleotide or deoxyribonucleotide with a nucleoside phosphitylating agent, wherein the phosphitylating agent includes a 5' -OH group protected by an acid-labile protecting group and a moiety bonded to the phosphorus atom therein that is a stronger proton acceptor than the 5'-OH group of the ribonucleotide or deoxyribonucleotide to form a reaction intermediate, then oxidizing the reaction intermediate so formed with a compound comprising a Lewis base and a boron-containing substituent, wherein the Lewis base is a weaker electron donor than the phosphite phosphorus of the reaction intermediate, to form a ribonucleotide or deoxyribonucleotide boranophosphate. These steps are repeated on the nucleotide boranophosphate to form an oligonucleotide boranophosphate.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: January 5, 1993
    Assignees: University of N.C. at Chapel Hill, Duke University, Boron Biologicals, Inc.
    Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall, Barbara Ramsay Shaw
  • Production of a cellulose-synthetic polymer composite fiber
    Patent number: 4378431
    Abstract: Hydrophilic characteristics are imparted to hydrophobic synthetic substrates, such as polyester fibers, by incubating a culture medium with Acetobacter bacterium in the presence of the substrate.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: March 29, 1983
    Assignee: The University of N.C. at Chapel Hill
    Inventor: Richard M. Brown, Jr.