Patents Assigned to University of Nebraska-Lincoln
  • Patent number: 5705660
    Abstract: The present invention is related to a novel class of decarboxylase enzyme inhibitors consisting of .alpha.-oxiranyl amino acids and derivatives thereof and a method of synthesizing such compounds.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: January 6, 1998
    Assignee: Board of Regents, University of Nebraska-Lincoln
    Inventors: David B. Berkowitz, Michelle L. Pedersen
  • Patent number: 5671573
    Abstract: A precast, prestressed concrete joist having web openings through which mechanical and electrical equipment may pass. In an exemplary embodiment, the joist comprises generally horizontal opposite top and bottom concrete members with a concrete web interposed between them. This web may have openings through which mechanical and electrical equipment may pass. Prestress steel strands may extend lengthwise through both the top and bottom members to provide prestress in the concrete joist. The concrete joist may further comprise strand restraining devices for deflecting the prestress steel strands. The precast, prestressed concrete joist having a web opening may be constructed using a reusable casting apparatus. This casting apparatus comprises a prestressing bed onto which a frame may be mounted. The frame provides a means of applying tension to the prestress steel strands and of supporting prestress strand restraining devices.
    Type: Grant
    Filed: April 22, 1996
    Date of Patent: September 30, 1997
    Assignee: Board of Regents, University of Nebraska-Lincoln
    Inventors: Maher K. Tadros, Amin Einea, Mohsen Saleh
  • Patent number: 5563328
    Abstract: The invention is directed to novel promoters or mutants thereof from Chlorella virus DNA methyltransferase genes. A Chlorella virus gene promoter is operably linked to a first and/or second DNA sequence encoding a gene that is different from the Chlorella virus gene to form an expression cassette. An expression cassette can be introduced into prokaryotic and/or eukaryotic cells and can provide for a high level of expression of the gene encoded by the first and/or second DNA sequence. The invention also provides a method for screening other Chlorella virus genes for promoters that can function to express a heterologous gene in prokaryotic and/or eukaryotic hosts.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: October 8, 1996
    Assignee: Board of Regents, University of Nebraska-Lincoln
    Inventors: Amitava Mitra, James L. Van Etten
  • Patent number: 5541102
    Abstract: Bovine cell line resistant to infection by the pestiviruses Bovine Viral Diarrhea Virus (BVDV), Hog Cholera Virus (HCV) and Border Disease Virus (BDV) and all progeny and mutants thereof. A bovine cell line (CRIB) that is resistant to infection by cytopathic and non-cytopathic BVDV and by other Pestiviruses due to a stable, recessive genetic defect which blocks infection at the level of viral entry.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: July 30, 1996
    Assignee: Board of Regents, University of Nebraska-Lincoln
    Inventors: Ruben O. Donis, Eduardo F. Flores
  • Patent number: 5541410
    Abstract: A single pass cylindrical mirror analyzer for use in charged particle analysis has reduced size for mounting on a simple manipulator. The reduced size of the analyzer allows for placement of the analyzer on a linear motion feedtrough mounted on a conflat flange for insertion into and retraction from the analysis position. The reduced size of the cylindrical mirror analyzer in combination with good instrument resolution results in a versatile charged particle analyzer.
    Type: Grant
    Filed: July 11, 1995
    Date of Patent: July 30, 1996
    Assignee: Board of Regents, University of Nebraska-Lincoln
    Inventors: Peter A. Dowben, David N. McIlroy
  • Patent number: 5200513
    Abstract: To produce doxorubicin and its analogues methyl 3alpha, 5alpha-dihydroxy-5beta-(trimethylsilylethynyl)-2alpha-nitromethylcyclohexa ne-1beta-carboxylate acetonide is condensed with 1,4-dihydro-4,4,5-trimethoxy-1-oxonaphthalene in the presence of 1,8-diazabicyclo-[5.4.0]undec-7-ene in an aprotic solvent to produce 3-[ (2beta-carbomethoxy-4beta-ethynyl-4alpha, 6alpha-(di-O-isopropylidenyl)cyclohexanyl-1-yl]-nitromethyl-4,4,5-trimetho xy-1-oxo-1,2,3,4-tetrahydronaphthalene; which is cyclized to produce 9beta-ethynyl-12-hydroxy-7alpha,9alpha-(di-O-isopropylidenyl)-6-nitro-4,5, 5-trimethoxy-5,5a,6,6a,7,8,9,10,10a,11-decahydro -11-naphthacenone. The decahydro-11-naphthacenone is converted to 7alpha-9alpha,(di-O-isopropyl-idenyl)-4,5-dimethoxy-9beta-ethynyl-12-hydro xy-6-nitro-6,6a,7,8,9,10,10a,11-octahydro-11, -naphthacenone.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: April 6, 1993
    Assignee: Board of Regents, University of Nebraska-Lincoln
    Inventor: Desmond M. S. Wheeler
  • Patent number: PP9847
    Abstract: A vegetatively reproduced buffalograss cultivar, named 315 Buffalograss, is distinguished by its excellent dark green color, high density, low growth habit, drought resistance, heat and cold tolerance, wear tolerance, low maintenance requirements and slow rate of establishment.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 1, 1997
    Assignee: Board of Regents, University of Nebraska Lincoln
    Inventors: Terrance P. Riordan, Susan A. de Shazer Steele, Milton C. Engelke, Leonard A. Wit, Jr., Frederick P. Baxendale, Jeana L. F. Svoboda, Jennifer M. Johnson-Cicalese, Edward J. Kinbacher