Abstract: Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

Abstract: In various embodiments, the present disclosure provides a method of treating a subject using laminin or a composition that includes laminin. In one embodiment, the method is used to enhance muscle regeneration, maintenance, or repair in a subject. In another embodiment, the method is used to promote wound healing. The method, in yet another embodiment, is used to prevent or reduce muscle damage or injury. In specific implementations of these methods, the laminin or composition that includes laminin is administered in a therapeutically effective amount. In some implementations, the laminin is a complete laminin protein. In other implementations, the laminin is a laminin fragment, a laminin derivative, or a laminin analogue.

Abstract: Locations of the origins of the photons are acquired from a scanned sample with reference to a scan frame. The location on the sample from which a photon was emitted is inferred from the location of the scan as commanded by a scan drive signal, a feedback signal related to the position of the scan device, or alternatively by the point in time during a scan at which the photon is detected. A position function, e.g., photon probability density, is associated with a photon position. Summing or other processing of photon probability density functions can require fewer photons to converge to an ideal density distribution associated with an image feature than are required using conventional pixel binning. Stored data can be mapped into pixels or voxels of a display or otherwise processed. Original data remains available in the digital storage for post-hoc analysis. Imprecision introduced by the display process need not adversely affect the precision of the collected data.

Abstract: A coordinated joint control system for controlling a coordinated joint motion system, e.g. an articulated arm of a hydraulic excavator blends automation of routine tasks with real-time human supervisory trajectory correction and selection. One embodiment employs a differential control architecture utilizing an inverse Jacobian. Modelling of the desired trajectory of the end effector in system space can be avoided. The disclosure includes image generation and matching systems.

Abstract: The invention provides a liquid cell for an atomic force microscope. The liquid cell includes a liquid cell housing with an internal cavity to contain a fluid, a plurality of conductive feedthroughs traversing the liquid cell housing between the internal cavity and a dry side of the liquid cell, a cantilevered probe coupled to the liquid cell housing, and a piezoelectric drive element disposed on the cantilevered probe. The cantilevered probe is actuated when a drive voltage is applied to the piezoelectric drive element through at least one of the conductive feedthroughs. A method of imaging an object in a liquid medium and a method of sensing a target species with the liquid cell are also disclosed.

Abstract: Apparatus and methods are disclosed for amplifying an energy beam such as a beam of laser light or a charged particle beam. An exemplary method includes providing a liner having a first end, a second end, a liner axis, and a lumen extending along the liner axis and being bound by interior reflective walls of the liner. An energy beam is introduced into the first end of the liner. The beam propagates through the lumen from the first end to the second end as the beam reflects multiple times from the interior walls of the liner. Meanwhile, an implosive force is applied to the liner. The implosive force compresses the interior walls implosively toward the liner axis in a manner that amplifies the beam as the beam propagates through the lumen of the imploding liner. The amplified energy beam can be used for any of various purposes including ignition of a fusion target.

Abstract: A permanent-magnet switched-flux (PMSF) device has an outer rotor mounted to a shaft about a central axis extending axially through the PMSF device. First and second pluralities of permanent-magnets (PMs) are respectively mounted in first and second circles, radially outwardly in first and second transverse planes extending from first and second sections of the central axis adjacent to an inner surface of the outer rotor. An inner stator is coupled to the shaft and has i) a stator core having a core axis co-axial with the central axis; and ii) first and second pluralities of stator poles mounted in first and second circles, radially outwardly from the stator core axis in the first and second transverse planes. The first and second pluralities of PMs each include PMs of alternating polarity.

Abstract: In various embodiments, the present disclosure provides filtering compositions, their method of production, and methods for their use. In specific implementations, the filtering composition includes lanthanum and has a surface area of at least about 125 g/m 2. In more specific examples, the filtering composition is free-flowing or has a moisture content between about 10 wt % about 30 wt %. Particular compositions include at least one of iron or magnesium. Some embodiments of the present disclosure provide filtering compositions that are resilient or leach-resistant.

Abstract: A control method and system for controlling a hydraulically actuated mechanical arm to perform a task, the mechanical arm optionally being a hydraulically actuated excavator arm. The method can include determining a dynamic model of the motion of the hydraulic arm for each hydraulic arm link by relating the input signal vector for each respective link to the output signal vector for the same link. Also the method can include determining an error signal for each link as the weighted sum of the differences between a measured position and a reference position and between the time derivatives of the measured position and the time derivatives of the reference position for each respective link. The weights used in the determination of the error signal can be determined from the constant coefficients of the dynamic model. The error signal can be applied in a closed negative feedback control loop to diminish or eliminate the error signal for each respective link.

Abstract: Locations of the origins of “discrete events,” e.g., photons or other units of radiant energy are acquired from a specimen with reference to a scan frame or other region of interest of the specimen. The location of origin of a discrete event can be determined from the corresponding location datum as derived from a scan-drive signal, a positional feed-back signal, or by a point in time during a unit of sampling time (“image-acquisition period”) at which the event is detected. A probability-density function (PDF) is associated with the detected locations. Summing or other processing of the PDFs is performed to produce imagable data. From the data, images can be produced that require fewer discrete events to converge to an ideal density distribution associated with an image feature than required by pixel-based binning methods. Stored data can be mapped into pixels or voxels of a display or otherwise processed, including post hoc processing.

Abstract: In some embodiments, systems and methods are provided for purifying a liquid, such as an impaired water. In some examples, seawater or brackish water is purified, such as to a potable level. Some configurations provide a system which includes a membrane-distillation unit, such as a vacuum-enhanced direct contact membrane distillation unit. The system also includes a forward-osmosis system, which may include one or more forward-osmosis units. A concentrated draw stream from the membrane-distillation unit, such as a concentrated brine solution, serves as a draw solution for a forward-osmosis unit, which may extract water from a source water, such as an impaired water. In some implementations, the forward-osmosis system includes a second forward-osmosis unit which uses the diluted draw solution from the first forward-osmosis unit as a draw solution to extract water from a source water. The system may include additional components, such as a heater or a buffer tank.

Abstract: The invention relates to a bioceramic coated apparatus and method of forming the same. The apparatus may be a medical implant such as, for example, an orthopedic implant or a dental implant. The bioceramic coating is designed to increase tissue and/or bone growth upon implantation of the apparatus. The apparatus has a valve metal substrate having a nanoporous valve metal oxide surface layer. The nanoporous surface layer contains a plurality of nanopores. The nanopores have adsorbed phosphate ions on at least their interior surfaces. A bioceramic coating is formed on the nanoporous surface and anchored into the nanopores. Optionally, the nanopores are formed into a tapered shape in order to increase adhesion to the bioceramic coating.

Abstract: The present invention relates to formation of nanocubes of sillenite type compounds, such as bismuth titanate, i.e., Bi12TiO20, nanocubes, via a hydrothermal synthesis process, with the resulting compound(s) having multifunctional properties such as being useful in solar energy conversion, environmental remediation, and/or energy storage, for example. In one embodiment, a hydrothermal method is disclosed that transforms nanoparticles of TiO2 to bismuth titanate, i.e., Bi12TiO20, nanocubes, optionally loaded with palladium nanoparticles. The method includes reacting titanium dioxide nanotubes with a bismuth salt in an acidic bath at a temperature sufficient and for a time sufficient to form bismuth titanate crystals, which are subsequently annealed to form bismuth titanate nanocubes. After annealing, the bismuth titanate nanocubes may be optionally loaded with nano-sized metal particles, e.g., nanosized palladium particles.

Abstract: Compounds of Formula (1) are disclosed. Cb is a carbocyclic or heterocyclic group having an atom within the cyclic structure selected from C, N, Si, and Cr and singly bound to A. A is CR, COR, CSR, CNR2, CCN, CCONR2, CNO2, CNNAr, CX1, or N. Cr is a chromophore having a substantially planar cyclic structure. The compounds function as nanometer-scale rotary molecular motors powered and controlled by light energy. The design of the molecular motor devices is flexible so that the rotary direction, drive light wavelength, and other physical characteristics can be varied. The compounds can be chemically functionalized to allow it to be integrated into or attached to a variety of structures. The device can be used in applications where mechanical power, positional control, and information encoding are to be generated at the size scale of individual molecules.

Abstract: Locations of the origins of the photons are acquired from a scanned sample with reference to a scan frame. The location on the sample from which a photon was emitted is inferred from the location of the scan as commanded by a scan drive signal, a feedback signal related to the position of the scan device, or alternatively by the point in time during a scan at which the photon is detected. A position function, e.g., photon probability density, is associated with a photon position. Summing or other processing of photon probability density functions can require fewer photons to converge to an ideal density distribution associated with an image feature than are required using conventional pixel binning. Stored data can be mapped into pixels or voxels of a display or otherwise processed. Original data remains available in the digital storage for post-hoc analysis. Imprecision introduced by the display process need not adversely affect the precision of the collected data.

Abstract: The invention relates to a method of making a nanotubular titania substrate having a titanium dioxide surface comprised of a plurality of vertically oriented titanium dioxide nanotubes containing oxygen vacancies. The method generally comprises the steps of anodizing a titanium metal substrate in an acidified fluoride electrolyte under conditions sufficient to form a titanium oxide surface comprised of self-ordered titanium oxide nanotubes, dispersing gold nanoparticles onto the titanium oxide surface, annealing the titanium oxide surface with the gold nanoparticles thereon in a non-oxidizing atmosphere, and depositing carbon onto the annealed titanium oxide surface. The invention also relates to a hybrid gold/carbon electrode formed by the method.

Abstract: The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups.

Abstract: The present disclosure provides methods and systems for purifying liquids. In a particular implementation, the system includes a forward-osmosis unit for diluting a water source for a downstream desalination unit. A pretreatment unit may be located hydraulically upstream of the desalination unit, such as upstream or downstream of the forward-osmosis unit. In certain embodiments, the system includes an extraction unit for extracting a relatively easily extractable osmotic agent from an osmotic draw solution. The system may include one or more forward-osmosis units downstream of the desalination unit for diluting a concentrated brine stream produced by the desalination unit. In particular embodiments, a downstream forward-osmosis unit uses the concentrated brine stream as an osmotic agent, such as to extract water from seawater or brackish water. Another downstream forward-osmosis unit may use impaired water as a feed stream.

Abstract: Magnetorheological materials having a supramolecular polymer gel as a component of the carrier are disclosed. Useful supramolecular polymers for gels include those having bipyridine or terpyridine ligands which can participate in metal coordination bonding. The magnetizable particles of magnetorheological materials can have supramolecular surfactant-polymer coatings.

Abstract: Localization methods and methods for localizing a light source using multivariate statistical analysis. In particular, a multi-variate distribution, such as a multi-variate normal distribution, may be used to localize photons originating from a light source and, in particular, may be used to analyze photon position maps acquired by Photon Event Distribution Sampling (PEDS). The multi-variate distribution assigned to each of the photons in the photon position map may be summed to predict a most probable location for the light source.