Patents Assigned to University of New England College of Osteopathic Medicine
  • Pyridomorphinans, pyridazinomorphinans and use thereof
    Patent number: 7951817
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: May 31, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, Southern Research Institute, University of New England College of Osteopathic Medicine, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • PYRIDOMORPHINANS, PYRIDAZINOMORPHINANS AND USE THEREOF
    Publication number: 20090239892
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Application
    Filed: March 19, 2009
    Publication date: September 24, 2009
    Applicants: Southern Research Institute, National Institute on Drug Abuse, National Institute of Health, University of New England College of Osteopathic Medicine, The Arizona Board of Reagents on behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • Pyridomorphinans, Pyridazinomorphinans and Use Thereof
    Publication number: 20080194568
    Abstract: Compounds represented by formula (I) wherein R is C1-6cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence of ? agonists.
    Type: Application
    Filed: August 27, 2004
    Publication date: August 14, 2008
    Applicants: Southern Research Institute, National Institute on Drugs Abuse, NIH, University of New England College of Osteopathic Medicine, The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca