Patents Assigned to University of Newcastle Upon Tyne
  • Patent number: 10314616
    Abstract: The present invention relates to egg chambers for use in collection, inspection and selection of eggs for in vitro fertilization (IVF) procedures. The egg chamber, in use, provides an effectively closed and fluid filled system which minimizes the environmental changes that a harvested egg is exposed to, thus maximizing viability. The egg chamber comprises a vessel which can be made airtight, comprising at least one side wall, an upper wall and a lower wall, at least a portion of the upper wall being transparent and at least a portion of the lower wall being light permeable; a first inlet with a sealable port; a first outlet with a sealable port; a filter with a pore size appropriate for egg collection disposed within the vessel between the first inlet and the first outlet and configured to separate the vessel into a first internal chamber and a second internal chamber.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: June 11, 2019
    Assignees: Labman Automation Ltd., University of Newcastle Upon Tyne, Newcastle Upon Tyne Hospitals NHS Foundation Trust
    Inventors: Robert Hodgson, Alison Murdoch
  • Publication number: 20190168021
    Abstract: An optogenetic system and method for preventing or halting seizures. The system and method use a sensor for monitoring the activity of a neural network containing a group of target neurons, and generating an input signal indicative of said activity, the target neurons being excitatory neurons. Excitatory stimulation is delivered in the form of an optical signal by an optical stimulator to the target neurons, the optical signal being determined based on the input signal, to reduce the overall activity of the target neurons.
    Type: Application
    Filed: July 28, 2017
    Publication date: June 6, 2019
    Applicant: University of Newcastle Upon Tyne
    Inventors: Andrew Jackson, Mark Cunningham, Stuart Baker, Patrick Degenaar
  • Patent number: 10300173
    Abstract: The invention relates to compounds, compositions and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: May 28, 2019
    Assignee: University of Newcastle Upon Tyne
    Inventors: James Grant Burgess, Michael John Hall, Reindert Nijland
  • Patent number: 10191062
    Abstract: The invention relates to a Model Gut System (MGS) comprising a pancreatic phase consisting essentially of synthetic pancreatic juice comprising pancreatin and one or more suitable pancreatic diluent(s) at a pH from about 7 to about 9, preferably about 7.9 to about 8.2, and porcine bile.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: January 29, 2019
    Assignee: University of Newcastle Upon Tyne
    Inventors: Jeff Pearson, Iain Brownlee, Matt Wilcox, Peter Chater, David Houghton
  • Publication number: 20190024539
    Abstract: There is disclosed an energy storage system. In particular, there is disclosed a chemisorption based energy storage system, able to provide electricity, heating or cooling depending on the desired energy output. The energy storage system includes a first chemical reactor containing a first sorbent material and a second chemical reactor containing a second sorbent material. The first and second chemical reactors are in mutual fluid connection such that a refrigerant fluid can flow from the first chemical reactor to the second chemical reactor, and from the second chemical reactor to the first chemical reactor. The first and second chemical reactors are further provided with means for putting heat in to, or taking heat out of, the first and/or the second chemical reactors. A heat exchanger module is also provided.
    Type: Application
    Filed: January 4, 2017
    Publication date: January 24, 2019
    Applicant: University of Newcastle Upon Tyne
    Inventors: Huashan BAO, Anthony Paul ROSKILLY
  • Patent number: 10182748
    Abstract: The present invention relates to a self monitoring device for attachment to the body, which incorporates real-time and correlated measurement of body movement and physiological analytes of metabolism (e.g. glucose) that can be modulated by physical activity. The system enables real time and personalized modulation of the selected physiological analyte(s) through appropriately selected cued activities and other evidence based clinical guidance dependent on previous and current analyte levels correlated with previous and current patterns of movement. The system also allows for personalization of the outputs with regular calibration to the user.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: January 22, 2019
    Assignee: University of Newcastle Upon Tyne
    Inventors: Michael Catt, Michael Trenell
  • Publication number: 20190002809
    Abstract: Aspects of the present invention relate to apparatus for use in cell and tissue culture techniques. Particularly, although not exclusively, embodiments of the present invention relate to apparatus which contribute to providing a dynamic cell culture environment. Also disclosed herein are methods for culturing cells and/or tissues, together with in vitro methods of testing drug efficacy as well as other subject matter.
    Type: Application
    Filed: October 21, 2016
    Publication date: January 3, 2019
    Applicant: University of Newcastle Upon Tyne
    Inventors: Fiona OAKLEY, Lee BORTHWICK, Clive GRIFFITHS, Michael DRINNAN
  • Patent number: 10125065
    Abstract: A method for the separation of diamond particle clusters into discrete diamond particles and/or into smaller diamond particle clusters comprising fewer diamond particles is disclosed. The diamond particle clusters are combined with at least one liquid phase organic or inorganic compound, or with a solution of at least one organic or inorganic compound in at least one solvent to form a reaction mixture. Mechanical means are then used to separate the diamond particle clusters into discrete diamond particles and/or into smaller clusters within the reaction mixture producing diamond particles with dangling bonds or free bonding sites on the surface of the diamond particles. The at least one organic or inorganic compound then reacts with these dangling bonds present on the diamond particle surface.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: November 13, 2018
    Assignee: University of Newcastle Upon Tyne
    Inventors: Lidija Siller, Yuriy Butenko
  • Patent number: 10072052
    Abstract: The invention discloses microorganism cell culture conditions that result in increased cellular and media concentrations of a biological pigment. The invention has applications in use as a natural food colouring, as antioxidants in the food supplement industries, in the nutraceutical, pharmaceutical, and cosmeceutical industries, and a non-toxic ink. The method results in pigment that is relatively easy to separate from the microorganism culture.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: September 11, 2018
    Assignee: UNIVERSITY OF NEWCASTLE UPON TYNE
    Inventors: Chelsea Marie Brain, Gary Stephen Caldwell
  • Patent number: 10054339
    Abstract: This invention relates to a chemisorption based energy storage device, able to provide electricity, heating or cooling depending on the desired energy output. The device typically comprises sorbent materials which have an affinity for a refrigerant gas at different temperatures.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: August 21, 2018
    Assignee: UNIVERSITY OF NEWCASTLE UPON TYNE
    Inventors: Huashan Bao, Anthony Paul Roskilly
  • Publication number: 20180207599
    Abstract: This invention relates to a method of chemical looping using non-stoichiometric materials with a variable degree of non-stoichiometry. One application of these methods is in the water gas shift reaction for H2 production. The methods of the invention can overcome limitations, e.g. those associated with chemical equilibria, which prevent chemical processes from proceeding with complete conversion of starting materials to products.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 26, 2018
    Applicant: University of Newcastle upon Tyne
    Inventor: Ian Metcalfe
  • Patent number: 9999632
    Abstract: The present invention provides the use of an alginate Io inhibit pancreatic lipase. The use may be directed to the control of weight in animals including human beings. Preferably the fraction of guluronate dimers in the alginate is at least 0.5.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 19, 2018
    Assignees: RD Biomed Limited, University of Newcastle upon Tyne
    Inventors: Johnathan Craig Richardson, Peter William Dettmar, Matthew David Wilcox, Iain Andrew Brownlee, Jeffrey Peter Pearson
  • Publication number: 20180155401
    Abstract: The invention discloses microorganism cell culture conditions that result in increased cellular and media concentrations of a biological pigment. The invention has applications in use as a natural food colouring, as antioxidants in the food supplement industries, in the nutraceutical, pharmaceutical, and cosmeceutical industries, and a non-toxic ink. The method results in pigment that is relatively easy to separate from the microorganism culture.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 7, 2018
    Applicant: University of Newcastle upon Tyne
    Inventors: Chelsea Marie Brain, Gary Stephen Caldwell
  • Publication number: 20180067122
    Abstract: The invention relates to a Model Gut System (MGS) comprising a pancreatic phase consisting essentially of synthetic pancreatic juice comprising pancreatin and one or more suitable pancreatic diluent(s) at a pH from about 7 to about 9, preferably about 7.9 to about 8.2, and porcine bile.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 8, 2018
    Applicant: University of Newcastle Upon Tyne
    Inventors: Jeff Pearson, Iain Brownlee, Matt Wilcox, Peter Chater
  • Publication number: 20180029893
    Abstract: This invention relates to methods of producing aerogels and composites thereof. In particular, the invention relates to methods of producing silica aerogels and composites thereof. The invention also relates to doped aerogels and doped silica aerogels. The method involves the use of alkaline solutions, and particularly aqueous alkaline solutions, during the aerogel drying process. The method is more energy efficient and cheaper than prior art methods.
    Type: Application
    Filed: February 16, 2016
    Publication date: February 1, 2018
    Applicant: UNIVERSITY OF NEWCASTLE UPON TYNE
    Inventors: LIDIJA SILLER, XIAO HAN
  • Patent number: 9879255
    Abstract: The present invention provides oligonucleotides that inhibit the binding of miR-27a to VE-cadherin mRNA, particularly in the form of blockmirs. The invention also provides compositions comprising such oligonucleotides and methods of use of such oligonucleotides to modulate the activity of VE-cadherin, inhibit or reduce vascular permeability, treat or prevent a vascular permeability-associated disease or condition, inhibit tumor growth, treat ischaemic injury, enhance recovery from ischaemic injury, treat surgical wounds and/or promotes post-operative recovery, and promote or induce angiogenesis.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: January 30, 2018
    Assignee: University of Newcastle Upon Tyne
    Inventors: Jennifer Gamble, Mathew Vadas, Thorleif Moller
  • Patent number: 9862750
    Abstract: The invention provides a chaperone/usher family polymer comprising at least one chaperone/usher family polypeptide monomer, wherein said at least one chaperone/usher family polypeptide monomer comprises an exogenous bioactive sequence.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: January 9, 2018
    Assignee: University of Newcastle Upon Tyne
    Inventor: Jeremy Lakey
  • Patent number: 9791456
    Abstract: The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of ?H2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: October 17, 2017
    Assignees: Vertex Pharmaceuticals Incorporated, University of Newcastle Upon Tyne
    Inventors: Susanna Falcon, Philip Reaper, John Pollard, Nicola Curtin, Fiona Middleton, Tao Chen
  • Patent number: 9789439
    Abstract: The present invention relates to the use of solid metal materials for catalyzing the hydration of carbon dioxide. It also relates to methods of and apparatus for hydrating carbon dioxide and capturing carbon. The solid metal materials may be nickel nanoparticles. The invention finds particular application in the sequestration of carbon dioxide either at the point of release or from the atmosphere.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: October 17, 2017
    Assignee: University of Newcastle upon Tyne
    Inventors: Lidija Siller, Gaurav Ashok Bhaduri
  • Publication number: 20170285770
    Abstract: A method, for a device, for enhancing user interaction with the device is provided. The method comprises the steps of: receiving a user input; receiving a signal comprising information indicating a motion and/or orientation of a sensor during a period of time occurring before, during, and/or after occurrence of the user input; performing an operation depending on the user input and the motion and/or orientation of the sensor.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 5, 2017
    Applicant: University of Newcastle Upon Tyne
    Inventors: Jonathan Hook, Patrick Olivier