Patents Assigned to University of North Carolina
  • Patent number: 12037579
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: July 16, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • Publication number: 20240216419
    Abstract: Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.
    Type: Application
    Filed: January 8, 2024
    Publication date: July 4, 2024
    Applicants: The University of North Carolina at Chapel Hill, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Katelyn Arnold, Ding Xu, Yongmei Xu, Rafal Pawlinski, Jian Liu
  • Patent number: 12026482
    Abstract: How to correctly understand natural language query and catch the useful information from it is a long-standing research question in the chatbot field. However, in many cases only a small set of words are sufficient for closed-domain tasks. In this paper, we propose Minimal Dictionary Language (MDL): a simple language architecture which allows users to express their needs through certain basic syntax. For the pilot study, we selected Enron email open dataset[2] for our experimental use and apply MDL as the language for email retrieval task. We also built a front-end search interface by Python Flask and Vue.js for test and evaluation purposes.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: July 2, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Javed Mostafa, Xiaopeng Lu, Sandeep Avula
  • Publication number: 20240197830
    Abstract: Interferon-?-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.
    Type: Application
    Filed: January 23, 2024
    Publication date: June 20, 2024
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Tuskegee University, The University of North Carolina at Chapel Hill, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Cecelia C. Yates-Binder, Jesse Jaynes, Monte S. Willis, Richard J. Bodnar, Zariel I. Johnson
  • Patent number: 12014915
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and/or manipulate ion trajectories.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: June 18, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Andrew Hampton, Kevin Schultze
  • Publication number: 20240190949
    Abstract: The present disclosure provides humanized antibodies and antigen-binding fragments thereof that specifically bind to SFRP2 and compositions comprising such humanized antibodies or antigen-binding fragments thereof. In some aspects, the humanized antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with increased SFRP2, such as cancer. In some aspects, the antibodies or antigen-binding fragments can be used to treat osteosarcoma.
    Type: Application
    Filed: January 12, 2024
    Publication date: June 13, 2024
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Nancy Demore, Cam Patterson
  • Publication number: 20240191260
    Abstract: Stable nucleic acid liquid formulations and methods of making and using the same are provided. According to some aspects, a method for preparing stable nucleic acid liquid formulations are provided that are resistant to nucleic acid degradation caused by enzyme-independent or enzymatic hydrolysis. In some instances, stable nucleic acid liquid compositions and methods or making the same incorporate the use of at least one of a polymer and/or a salt to form a macroscopic RNA-rich condensate. In other aspects, a method for preparing stable nucleic acid encapsulated lipid nanoparticle (LNP) liquid formulations is provided that are resistant to degradation caused by nucleic acid hydrolysis, LNP leakage, and LNP aggregation. In some instances, stable nucleic acid liquid compositions and methods or making the same incorporate the use of a pair of thermodynamically matching LNP synthesis buffer and LNP product formulation buffer with close-to-equal osmotic pressure and chemical potentials of solution components.
    Type: Application
    Filed: December 8, 2023
    Publication date: June 13, 2024
    Applicant: University of North Carolina at Wilmington
    Inventors: Ying Wang, Harrison R. Wooten, Carson Jackson
  • Patent number: 12006554
    Abstract: Methods and compositions are provided for determining a subtype of head and neck squamous cell carcinoma (HNSCC) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for HNSCC. Also provided herein are methods and compositions for determining the response of an individual with a HNSCC subtype to a therapy such as immunotherapy.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: June 11, 2024
    Assignees: GeneCentric Therapeutics, Inc., The University of North Carolina at Chapel Hill
    Inventors: Myla Lai-Goldman, Hawazin Faruki, Greg Mayhew, Charles Perou, David Neil Hayes
  • Publication number: 20240180158
    Abstract: In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of various fungal infections and/or other diseases. In some embodiments, a method for the inactivation of a microbial enzyme is provided comprising providing a compound having a selective inactivation activity, providing an enzyme target, and inactivating the enzyme target. In some example embodiments, the compound comprises a sulfonyl group.
    Type: Application
    Filed: January 19, 2024
    Publication date: June 6, 2024
    Applicants: University of North Carolina at Wilmington, THE UNIVERSITY OF TOLEDO
    Inventors: Christopher John HALKIDES, Ronald E. Viola
  • Patent number: 12000003
    Abstract: Provided are methods for identifying pancreatic cancer subtypes in a subject and treating the same. In some embodiments, the method comprise obtaining gene expression levels for each of the following genes in the biological sample: GPR87, KRT6A, BCAR3, PTGES, 1TGA3, C16orf74, S100A2, KRT5, REG4, ANXA10, GATA6, CLDN18, LGALS4, DDC, SLC40A1, CLRN3; performing pair-wise comparisons of gene expression levels for combinations of these genes, and calculating a Raw Score for the biological sample, wherein the Raw Score is indicative of the pancreatic cancer subtype in the subject. Also provided are methods for identifying differential treatment strategies for subjects diagnosed with PDAC, methods for treating PDAC patients based on the subtype of PD AC the patients have; and methods for classifying subjects diagnosed with PDAC as having a basal-like subtype or a classical subtype of PDAC.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: June 4, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jen Jen Yeh, Richard Moffitt, Naim Ur Rashid
  • Publication number: 20240173338
    Abstract: In one aspect, compounds and associated pharmaceutical compositions are described herein comprising isolated cannabicitran (CBT-C (3)). In some embodiments, CBT-C (3) enantiomers are isolated and/or prepared. In some further embodiments, the biological activity of enantiomers are determined. In some further embodiments, one or more enantiomers may be incorporated into a composition.
    Type: Application
    Filed: November 21, 2023
    Publication date: May 30, 2024
    Applicant: University of North Carolina at Wilmington
    Inventors: Robert Thomas Williamson, Jeremy B. Morgan, Jared S. Wood, William H. Gordon
  • Patent number: 11993627
    Abstract: Methods of synthesizing chondroitin sulfate oligosaccharides are provided. Enzymatic schematic approaches to synthesizing structurally defined homogenous chondroitin sulfate oligosaccharides at high yields are provided. Synthetic chondroitin sulfate oligosaccharides ranging from 3-mers to 15-mers are provided.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: May 28, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jian Liu, Jine Li, Guowei Su
  • Patent number: 11982693
    Abstract: Apparatuses and methods of the present disclosure integrate a non-intrusive current sensor in the form of a current mismatch sensor into a power module having paralleled semiconductor structures or components. The current mismatch can be detected by the current sensor by monitoring a magnetic flux density between the paralleled components or devices.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 14, 2024
    Assignee: The University of North Carolina at Charlotte
    Inventors: Babak Parkhideh, Andreas Lauer
  • Patent number: 11984759
    Abstract: Methods of operating a grid ancillary service with an uninterruptible power supply (GAUPS) device are provided. A method of operating a GAUPS device includes controlling a switch of the GAUPS device in response to a signal that is generated by the switch, to control efficiency of an inverter and quality of power supplied to a load via the inverter. The switch is coupled between the inverter and the load. Related systems and devices are also provided.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: May 14, 2024
    Assignee: The University of North Carolina at Charlotte
    Inventors: Sukumar Kamalasadan, Robin Bisht, Sherif Abdelrazek
  • Patent number: 11976136
    Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: May 7, 2024
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Hector Aldaz, Shane Krummen Atwell, Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • Patent number: 11970560
    Abstract: The invention generally relates to linear-bottlebrush-linear copolymer blocks and methods of making and using same. The disclosed copolymer blocks can be useful in, for example, the formation of polymer networks that replicate biological stress-strain behavior. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: September 3, 2018
    Date of Patent: April 30, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Sergei Sheiko, Mohammad Vatankhah-Varnosfaderani
  • Patent number: 11963785
    Abstract: Methods, systems, and computer readable media for utilizing visuomotor error augmentation for balance rehabilitation are provided. An exemplary method includes displaying a dynamic virtual environment defined by an optical flow, obtaining position data of an anatomical portion of a subject that is virtually traversing the dynamic virtual environment, and using the position data to determine a mediolateral displacement measurement of the subject. The method further includes utilizing the mediolateral displacement measurement to define feedback control loop data, establishing an augmented visual error that dynamically adjusts the dynamic virtual environment, wherein the augmented visual error is based on the feedback control loop data and a predefined visual gain factor, and adjusting the optical flow of the dynamic virtual environment by using the augmented visual error.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: April 23, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Jason Roy Franz, Mu Qiao
  • Patent number: 11960524
    Abstract: The subject matter described herein relates to methods, systems, and computer readable media for dynamic cluster-based search and retrieval. An example method for dynamic cluster-based search and retrieval occurs at a server.
    Type: Grant
    Filed: September 2, 2022
    Date of Patent: April 16, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Javed Mostafa, Michael Segundo Ortiz, Kazuhiro Seki, Mengqian Wang, Heejun Kim
  • Patent number: 11957444
    Abstract: This specification describes systems and methods for using Zero Echo Time (ZTE) magnetic resonance imaging (MRI) sequences for applications to functional MRI (fMRI). In some examples, a system for functional magnetic resonance imaging includes a magnetic resonance imaging (MRI) scanner and a control console implemented on at least one processor. The control console is configured for executing, using the MRI scanner, a zero echo time (ZTE) pulse sequence; acquiring, using the MRI scanner, magnetic resonance data in response to the ZTE pulse sequence; and constructing at least one MRI image using the magnetic resonance data and measuring tissue oxygenation (PtO2)-related T1 changes as a proxy of neural activity changes of a subject using the at least one MRI image.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: April 16, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Yen-Yu Shih, Martin John MacKinnon, Yuncong Ma, Wei-Tang Chang
  • Patent number: 11961392
    Abstract: An edge device for monitoring safety of a highway work zone is disclosed. The edge device includes at least one camera, one or more processors, and memory. The at least one camera is configured to capture images in sequence. The memory stores computer-executable instructions that, when executed, cause the one or more processors to: perform vehicle detection over an input of a data stream of the images, from the at least one camera, utilizing just-in-time processing; determine a level of safety by tracking vehicles detected and performing a time sequence analysis of the vehicles; and send a signal to one or more assisted reality devices indicating the level of safety thereto.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: April 16, 2024
    Assignee: The University Of North Carolina At Charlotte
    Inventors: Hamed Tabkhivayghan, Omidreza Shoghli