Patents Assigned to University of North Carolina at Charlotte
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Publication number: 20230049618Abstract: Provided are antibodies, and fragments and derivatives thereof, particularly humanized derivatives thereof, which bind to tumor antigens. Also provided are nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens, polypeptides and CARs encoded by the nucleic acid molecules, vectors and host cells that include the nucleic acid molecules, methods of making the same, and methods for using the same to generate a persisting population of genetically engineered T cells in a subject, expanding a population of genetically engineered T cells in a subject, modulating the amount of cytokine secreted by a T cell, reducing the amount of activation-induced calcium influx into a T cell, providing an anti-tumor immunity to a subject, treating a mammal having a MUC1-associated disease or disorder, stimulating a T cell-mediated immune response to a target cell population or tissue in a subject, and imaging a MUC1-associated tumor.Type: ApplicationFiled: August 3, 2022Publication date: February 16, 2023Applicants: The University of North Carolina at Charlotte, OncoTAb, Inc.Inventors: Pinku Mukherjee, Jordon Wang, Kexin Huang, Yan He
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Patent number: 11554181Abstract: Provided are antibodies, and fragments, derivatives, and nanoparticle conjugates thereof, particularly humanized derivatives thereof, which bind to tumor antigens. Also provided are nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens, polypeptides and CARs encoded by the nucleic acid molecules, vectors and host cells that include the nucleic acid molecules, methods of making the same, and methods for using the same to generate a persisting population of genetically engineered T cells in a subject, expanding a population of genetically engineered T cells in a subject, modulating the amount of cytokine secreted by a T cell, reducing the amount of activation-induced calcium influx into a T cell, providing an anti-tumor immunity to a subject, treating a mammal having a MUC1-associated disease or disorder, stimulating a T cell-mediated immune response to a target cell population or tissue in a subject, and imaging a MUC1-associated tumor.Type: GrantFiled: September 3, 2019Date of Patent: January 17, 2023Assignees: The University of North Carolina at Charlotte, OncoTab, Inc.Inventors: Pinku Mukherjee, Jordon Wang, Kexin Huang, Yan He
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Patent number: 11542181Abstract: In one aspect, separation media are described herein operable for removing one or more water contaminants including NOM and derivatives thereof. Briefly, a separation medium includes a nanoparticle support and an oligomeric stationary phase forming a film on individual nanoparticles of the support, the film having thickness of 1 to 100 nm. In some embodiments, oligomeric chains of the stationary phase are covalently bonded to the individual nanoparticles.Type: GrantFiled: November 30, 2016Date of Patent: January 3, 2023Assignee: UNIVERSITY OF NORTH CAROLINA AT CHARLOTTEInventors: Jordan Poler, James E. Amburgey, Billy R. Johnson, Amir Y. Alansari, Timothy Eldred
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Patent number: 11443842Abstract: Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk proximate to a target volume of a patient. The method includes determining automatically one or more radiation treatment beam configuration sets. Further, the method includes presenting the determined one or more radiation beam configuration sets via a user interface.Type: GrantFiled: December 19, 2019Date of Patent: September 13, 2022Assignees: Duke University, The University of North Carolina at CharlotteInventors: Qingrong Jackie Wu, Yaorong Ge, Fang-Fang Yin, Lulin Yuan
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Publication number: 20220241614Abstract: A radiation treatment planning system can include a machine learning system that receives patient data, including an image scan (e.g., CT scan) and contour(s), a physician prescription, including planning target and dose, and device (radiation beam) data and outputs predicted fluence maps. The machine learning system includes at least two stages, where a stage of the at least two stages includes converting image scans from the patient data to projection images. A treatment planning system can receive the predicted fluence maps and generates treatment plans without performing inverse optimization.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Applicant: The University of North Carolina at CharlotteInventors: Qingrong Wu, Yaorong Ge, Fang-Fang Yin, Qiuwen Wu, Chunhao Wang, Yang Sheng, Xinyi Li, Wentao Wang
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Patent number: 11358004Abstract: Systems and methods for radiation treatment planning based on a model of planning strategies knowledge including treatment states and treatment actions are disclosed. According to an aspect, a method includes receiving geometric characterization data of a target volume for radiation treatment of a patient. The method also includes receiving geometric characterization data of at least one organ at risk proximate the target volume. Further, the method includes constructing a model for applying a predetermined radiation dosage to the target volume based on the received data. The model includes treatment states and associated treatment actions selectable to implement at each state. The method includes presenting information about at least one treatment state, the treatment actions associated with the at least one treatment state, and the rewards associated with the treatment actions associated with the at least one treatment state. The method also includes reconstructing the model.Type: GrantFiled: May 11, 2020Date of Patent: June 14, 2022Assignees: Duke University, The University of North Carolina at CharlotteInventors: Qingrong Wu, Yaorong Ge, FangFang Yin, Chunhao Wang, Jiahan Zhang, Manisha Palta, Yang Sheng
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Patent number: 11292749Abstract: In one aspect, composite carbide compositions are described herein which can facilitate the efficient and/or economical manufacture of articles comprising SiC. Briefly, a composite carbide composition comprises silicon carbide (SiC) particles and a silica interparticle phase covalently bonded to the SiC particles.Type: GrantFiled: January 18, 2018Date of Patent: April 5, 2022Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTEInventors: Ahmed El-Ghannam, Tony Schmitz
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Patent number: 11285242Abstract: Silicon carbide (SiC) is an inert material with excellent biocompatibility properties. The biocompatibility is associated with the chemical inertness of the material. Tissue response to inert material is the formation of thin fibrous capsule. In some embodiments described herein, the conversion of SiC from inert material to bioactive material capable of stimulating cell function and making direct bond with tissue is described and the body response to bioactive materials is direct binding without any fibrous capsule.Type: GrantFiled: December 17, 2020Date of Patent: March 29, 2022Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTEInventor: Ahmed El-Ghannam
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Patent number: 11218148Abstract: Various examples are provided related to diode clamped solid-state circuit breakers (SSCBs). Their configuration allows operation of the SSCB without dynamic voltage balancing issues. In one example, a diode clamped SSCB includes source-side switches and line-side switches connected between a DC source connection and a line-side connection. Clamping capacitors are connected at a common connection point between the source-side and line side switches and source-side and line-side clamping diodes are connected between the source-side switches and line-side switches and the clamping capacitors. Sequential switching of the source-side switches or line-side switches can avoid dynamic voltage balancing issues.Type: GrantFiled: September 4, 2020Date of Patent: January 4, 2022Assignee: University of North Carolina CharlotteInventors: Madhav Manjrekar, Ehab H. Shoubaki, Tiancan Pang
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Patent number: 11174201Abstract: Carbon dioxide and ash are two major waste by-products from coal fire production. Presented herein is are methods, material, and devices for storing carbon using high ash-content building material. The idea is to generate materials with commercial values to offset the cost for carbon capture. Ash with alkali activator (geopolymer) concrete has been studied extensively for its superior performance (higher strength) than ordinary Portland cement (OPC) concrete. However, most geopolymer concrete needs energy input in the forms of pressure and heat, which in turn are usually based on electricity produced through power plants.Type: GrantFiled: October 23, 2019Date of Patent: November 16, 2021Assignee: The University of North Carolina at CharlotteInventor: Shen-En Chen
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Patent number: 11124439Abstract: Devices, systems, and methods for heterogeneous catalytic quenching of hydrogen peroxide (H2O2) in a water source are disclosed. An exemplary device includes a column containing a catalytic material. The catalytic material can include self-supported granules of Fe(III) oxide. Catalytic reactor systems incorporating the columns and methods of making and using the same are also disclosed.Type: GrantFiled: December 7, 2016Date of Patent: September 21, 2021Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTEInventor: Olya Stepanovna Keen
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Patent number: 11065471Abstract: Systems and methods for automatic, customized radiation treatment plan generation for cancer are disclosed. According to an aspect, a method includes receiving data indicating anatomy information of a patient and radiation beam characteristics of a radiation therapy system. Further, the method includes determining energy levels for application of radiation beams to the patient.Type: GrantFiled: November 21, 2016Date of Patent: July 20, 2021Assignees: Duke University, The University of North Carolina at CharlotteInventors: Qingrong Jackie Wu, Yaorong Ge, Taoran Li, Fang-Fang Yin, Yang Sheng
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Patent number: 11040896Abstract: In one aspect, systems and methods for the efficient and cost-effective removal of bromide from wastewater streams are described herein. Briefly, a system for bromide removal comprises pretreatment apparatus operable for at least partial removal of background ionic species from the wastewater stream and/or dilution of the background ionic species in the wastewater stream. The system also comprises bromide capture apparatus operable for removal of bromide from the pretreated wastewater stream, wherein the system removes bromide from the wastewater stream at an efficiency of at least 80 percent. In some embodiments, bromide is recovered from the capture apparatus and reused in flue gas treatment applications.Type: GrantFiled: June 15, 2017Date of Patent: June 22, 2021Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTEInventors: James E. Amburgey, Olya Stepanovna Keen, Mei Sun
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Patent number: 11008575Abstract: Disclosed herein are unique single stranded DNA oligonucleotide products identified as binding with high affinity and specificity to ovarian tumor cells that may be used in the delivery of therapy to and diagnosis of ovarian cancer.Type: GrantFiled: February 20, 2017Date of Patent: May 18, 2021Assignee: The University of North Carolina at CharlotteInventors: Christine Richardson, Gregory Benedetto
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Patent number: 10965124Abstract: Apparatuses including power electronics circuitry are provided. The power electronics circuitry includes at least one power converter that is coupled to a DC bus. Moreover, in some embodiments, the at least one power converter is configured to regulate a voltage of the DC bus. Related methods of operating an apparatus including power electronics circuitry are also provided.Type: GrantFiled: January 26, 2018Date of Patent: March 30, 2021Assignees: DUKE ENERGY CORPORATION, THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTEInventors: Stuart Laval, Aleksandar Vukojevic, Somasundaram Essakiappan, Madhav Manjrekar, Ehab Shoubaki
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Patent number: 10914866Abstract: Materials comprising metamaterials exhibiting form-induced birefringence and anisotropic optical properties are provided. The disclosed articles comprise structures with critical dimensions which are on the order of or smaller than the wavelength for the gigahertz and terahertz spectral range. Methods of preparing same using stereolithography are disclosed. In a further aspect, the disclosed methods pertain to spectroscopic ellipsometry methods comprising a biaxial (orthorhombic) layer homogenization approach is to analyze the terahertz ellipsometric data obtained at three different sample azimuth orientations. The disclosed articles and methods demonstrate provide an avenue to fabricate metamaterials for the terahertz spectral range and allows tailoring of the polarizability and anisotropy of the host material. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: July 17, 2018Date of Patent: February 9, 2021Assignees: HARRIS CORPORATION GCS, UNIVERSITY OF NORTH CAROLINA CHARLOTTE, J.A. WOOLLAM CO. INC.Inventors: Tino Hofmann, Daniel Fullager, Stefan Schoeche, Craig M. Herzinger, Susanne Madeline Lee, Erin Kathleen Sharma
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Patent number: 10782323Abstract: Various examples are provided for contactless wideband current sensing. A combination of magnetoresistive (MR) sensor and Rogowski coil outputs can be combined to provide current sensing from DC to 10 MHZ or more. In one example, a system includes a MR sensor that can provide an MR output voltage corresponding to a magnitude of the current through a trace; a Rogowski coil sensor that can provide a Rogowski output voltage corresponding to a magnitude of the current; and processing circuitry configured to generate an output current signal by aggregating the MR and Rogowski output voltages. In another example, a method includes conditioning an output from a MR sensor disposed adjacent to a trace carrying a current; conditioning an output from a Rogowski coil disposed adjacent to the trace; and aggregating the first and second conditioned signals to provide an output current signal corresponding to the current passing through the trace.Type: GrantFiled: May 12, 2017Date of Patent: September 22, 2020Assignee: University of North Carolina CharlotteInventors: Babak Parkhideh, Shahriar Jalal Nibir
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Patent number: 10784650Abstract: Example photoconductive devices and example methods for using photoconductive devices are described. An example method may include providing a photoconductive device having a metal-semiconductor-metal structure. The method may also include controlling, based on a first input state, illumination of the photoconductive device by a first optical beam during a time period, and controlling, based on a second input state, illumination of the photoconductive device by a second optical beam during the time period. Further, the method may include detecting an amount of current produced by the photoconductive device during the time period, and based on the detected amount of current, providing an output indicative of the first input state and the second input state. The example devices can be used individually as discrete components or in integrated circuits for memory or logic applications.Type: GrantFiled: July 25, 2017Date of Patent: September 22, 2020Assignee: The University of North Carolina at CharlotteInventors: Yong Zhang, Jason Kendrick Marmon
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Patent number: 10727669Abstract: Apparatuses including power electronics circuitry are provided. The power electronics circuitry includes at least one power converter that is coupled to a DC bus. Moreover, in some embodiments, the at least one power converter is configured to regulate a voltage of the DC bus. Related methods of operating an apparatus including power electronics circuitry are also provided.Type: GrantFiled: January 26, 2018Date of Patent: July 28, 2020Assignees: Duke Energy Corporation, The University of North Carolina at CharlotteInventors: Stuart Laval, Aleksandar Vukojevic, Somasundaram Essakiappan, Madhav Manjrekar, Ehab Shoubaki
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Patent number: 10718597Abstract: The present disclosure is directed to significantly improving the adiabatic shear banding susceptibility of pure refractory metals as well as overcoming the physical dimension limitations when making kinetic energy penetrators. These improvements may be achieved by arranging interlayers between plasticly deformed refractory metal material layers. Disclosed herein are methods of making material for kinetic energy penetrator applications, the methods comprising: severely plasticly deforming a refractory metal material until the grain size of the refractory metal material is within one of ultrafine grain and nanocrystalline regimes; arranging an interlayer material adjacent the refractory metal material; and diffusion bonding the interlayer material to the refractory metal material.Type: GrantFiled: July 23, 2018Date of Patent: July 21, 2020Assignee: The University of North Carolina at CharlotteInventors: Qiuming Wei, Xiaoxue Chen