Abstract: Provided is an insert adapter for direct ink writing printers (DIW) and methods of fiber alignment in direct ink writing. The insert adapter is sized to fit snugly inside a print barrel DIW 3D printer. The adapter includes channels. The DIW printer with insert adapter, can be used in a passive method for microfiber alignment in DIW printing. The method includes feeding a non-Newtonian ink including microfibers through the print barrel such that the ink flows into the channels of the insert adapter before exiting through a print nozzle, causing the microfibers to align along the direction of ink flow.

Abstract: The present disclosure provide for coatings, coated structures, methods of coating, methods of coating a structure, and the like. In an aspect, the coating is a tribocatalytically-active coating, where the tribocatalytically-active coating interacts with the hydrocarbon environment forming a protective carbon-based tribofilm on the surface of the coating, which can be actively formed (reformed) during use of the coated structure within the hydrocarbon environment.

Abstract: The present invention includes a method for identifying a patient response to treatment for Alzheimer's Disease with a non-steroidal anti-inflammatory drug (NSAID) or an acetylcholinesterase (AChE) inhibitor drug comprising: obtaining a blood or serum sample from the patient; determining the presence of a proinflammatory endophenotype in the blood or serum sample of the patient; using the proinflammatory endophenotype to detect treatment response (a responder, a stable, a non-responder or an adverse responder); and treating the patient with the NSAID or the AChE inhibitor if the patient is in the responder or the stable treatment response phenotype group; or preventing a treatment with the NSAID or the AChE inhibitor if the patient is a non-responder or an adverse responder.

Abstract: Chemical composition of a component fabricated using high energy density input based three-dimensional additive manufacturing is in-situ monitored in real time. Laser Energy Assisted Breakdown Spectroscopy (LEABS) is coupled with a rapid physics-informed peak identification algorithm (RPIPIA) to monitor the atomic composition of component material (metallic, intermetallic, ceramic and metallic or ceramic matrix composites) in pseudo-real time during its fabrication using high energy density (laser, ion beam, gas plasma, electric resistance/discharge, gas torch) input (HEDI) based additive manufacturing.

Abstract: Provided is an insert adapter for direct ink writing printers (DIW) and methods of fiber alignment in direct ink writing. The insert adapter is sized to fit snugly inside a print barrel DIW 3D printer. The adapter includes channels. The DIW printer with insert adapter, can be used in a passive method for microfiber alignment in DIW printing. The method includes feeding a non-Newtonian ink including microfibers through the print barrel such that the ink flows into the channels of the insert adapter before exiting through a print nozzle, causing the microfibers to align along the direction of ink flow.

Abstract: The present disclosure is directed to an SR-B1-targeting nanomicelle and compositions, methods of synthesis and methods of use thereof. The nanomicelle may be an HDL-mimetic drug delivery system and may be cross-linked with DSS. The composition may contain a therapeutic agent with the ability to treat cancers, especially sarcomas.

Abstract: The disclosure provides recombinant LAC polynucleotides encoding a laccase (LAC) polypeptide capable of polymerizing caffeyl alcohol, vectors and cells including the recombinant LAC polynucleotide. The disclosure also provides transgenic plants including cells having the recombinant LAC polynucleotide of the present disclosure and methods of increasing production of C-lignin in a plant.

Abstract: The present disclosure provides a system, method, and apparatus for detecting chemical effluents in an environment using Teslin substrates. To illustrate, a system includes one or more Teslin substrates which can capture molecules present in an ambient environment. The system includes a housing with the one or more Teslin substrates disposed within the housing. The system further includes means for selectively exposing different portions of the one or more Teslin substrates to the ambient environment, in which the molecules present in the ambient environment are captured by the different portions of the one or more Teslin substrates as the different portions of the one or more Teslin substrates are exposed. The system can include that the means for selectively exposing different portions of the one or more Teslin substrates is an aperture in the housing.

Abstract: The present invention includes methods for selecting a therapy for improved cognition as well as prevention of cognitive loss/dysfunction using one or more endophenotypes comprising: obtaining a sample from a subject; measuring biomarkers that differentiate between an inflammatory, a metabolic, a neurotrophic, and a depressive endophenotype; and selecting a course of treatment for the subject based on whether the subject is scored as having a high or a low endophenotype for one or more of the inflammatory, a metabolic, a neurotrophic, and a depressive endophenotypes.

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule collector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A photodiode array configured to excite and/or heat the molecule collector to release at least a portion of the VOCs from the molecule collector to release at least the portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified target VOC(s). The output may include information that quantitates a concentration of the target VOC(s) with respect to a source of the breath sample.

Abstract: An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule collector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may introduce heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified one or more target VOCs. The output may include information that quantitates a concentration of the one or more target VOCs with respect to a source of the breath sample.

Abstract: An exemplary breath analysis system disposed in a portable housing may include a sampling chamber having a molecule collector disposed therein. The molecule collector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may introduce heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector. An analysis device disposed in the portable housing (e.g., a mass spectrometer or Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified one or more target VOCs. The output may include information that quantitates a concentration of the one or more target VOCs with respect to a source of the breath sample.

Abstract: The present application relates to systems, methods, and computer-readable media for providing generating odors. In aspects, the disclosed methods may include generating, by a chemistry dispersion element, a signal configured to act upon a surface of a chemistry reservoir to disperse an odorous substance retained within the chemistry reservoir. The chemistry reservoir and the chemistry dispersion element may be disposed within a housing. The method also includes generating, by an air pump, a volume of air, and transporting, by an airflow pathway, the volume of air from the air pump to an air outlet. The volume of air passes through at least a portion of the housing as it flows through the airflow pathway from the air pump to the air outlet, and transports at least a portion of the odorous substance dispersed by the chemistry reservoir within the housing to the air outlet.

Abstract: A new insight on the lubrication of artificial joint components is presented. Addition of small amounts of nanoscale diamond particles to an artificial joint promotes a substantial improvement in friction and wear behavior of the artificial joint surfaces. Artificial joint implants are made from a variety of materials ranging from metal alloys to polymers. Suitable methods of applying nanoscale diamond particles to an artificial joint include (i) coating an effective amount of nanoscale diamond particles onto the artificial joint prior to implants; (ii) applying a composition to the artificial joint during an artificial joint implanting surgery, wherein said composition comprises a biocompatible carrier fluid and an effective amount of nanoscale diamond particles dispersed in the biocompatible carrier fluid; (iii) injecting the composition for lubricating the artificial joint into the artificial joint.

Abstract: An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule collector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may ramp heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector, lighter and/or less bound VOCs first, heavier and/or more strongly bound VOCs later. An analysis device (e.g., a mass spectrometer or a Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified target VOC(s). The output may include information that quantitates a concentration of the target VOC(s) with respect to a source of the breath sample.

Abstract: The present invention includes an apparatus and method for detecting the location of one or more sources of one or more target molecule, the apparatus comprising: a molecule detector; and a processor connected to the molecule detector and to a global position system, wherein the processor calculates the presence of the one or more target molecules, runs a computer code that determines a dynamic reverse gas stack model for the one or more target molecules, and triangulates the possible position for a source or effluent of the one or more target molecules based on the dynamic reverse gas stack model. The determined reverse gas stack model may have a Gaussian dispersion over one or more sampled locations.

Abstract: An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule detector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may introduce heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or Terahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified one or more target VOCs. The output may include information that quantitates a concentration of the one or more target VOCs with respect to a source of the breath sample.

Abstract: The present disclosure presents aerial communication systems and methods. One such system comprises an unmanned aerial vehicle platform and a communication component integrated with the unmanned aerial vehicle platform, wherein the communication component is configured to establish an Air to Air (A2A) communication channel with a remote directional antenna that is integrated with a remote unmanned aerial vehicle platform. The system further includes a computing component integrated with the unmanned aerial vehicle platform, wherein the computing component is configured to determine an optimal heading angle for transmission of communication signals from a directional antenna to the remote directional antenna in an unknown communication environment from received signal strength indicator (RSSI) information obtained from the remote directional antenna. Other systems and methods are also disclosed.

Abstract: Two-dimensional (2D) material-based metal or alloy catalysts synthesized on carbon materials (e.g., carbon nanotubes) prevent polysulfide shuttling and overcome technical challenges for developing practical lithium-sulfur (Li—S) batteries. Soluble lithium polysulfides (LiPSs) tend to shuttle during battery cycling and corrode a Li anode, leading to eventual performance fading in the Li—S battery. This shuttle effect can be reduced by accelerating the conversion of the dissolved polysulfides to the insoluble LiPSs and back to the sulfur. A 2D material-based alloy or 2D material synthesized on carbon materials can suppress polysulfide shuttling by catalyzing polysulfide reactions. 2D material-based alloys with 2H (semiconducting)—1T (metallic) mixed phase exhibit synergistic effects of accelerated electron transfer and catalytic performance as confirmed by the lower charge-transfer resistance of carbon nanotube (CNT)—S cathode and the high binding energy of LiPSs to the catalyst.