Abstract: The present invention relates to an immunoglobulin derived single-chain fragment variable (scFv) that broadly binds HLA II molecules and uses thereof. In particular, targeting of an antigen to antigen presenting cells with the HLAII-specific targeting unit provided herein find use in enhancing immune responses after vaccination.

Abstract: Provided herein, in some aspects, are compositions and methods to inhibit AFP interactions with ?2M and/or Class I-related molecule interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate AFP interactions with ?2M and/or Class I-related molecule in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels is desired to increase immunosuppression or enhance organ regeneration.

Abstract: The disclosure relates to outer membrane vesicles from Francisella and Piscirickettsia, and their use in vaccine compositions. In particular, the present disclosure relates to compositions and methods useful in inducing protective immunity against francisellosis or salmon rickettsial septicaemia (SRS) in fish.

Abstract: The present invention relates to albumin variants with an improved affinity for the neonatal Fc receptor (FcRn) and uses thereof, and in particular to the use of such albumin variants as carriers for immunogens. In some embodiments, the present invention relates to vaccines (e.g., vaccines for mucosal delivery) comprising albumin/immunogen fusion proteins.

Abstract: The disclosure relates to outer membrane vesicles from Francisella and Piscirickettsia, and their use in vaccine compositions. In particular, the present disclosure relates to compositions and methods useful in inducing protective immunity against francisellosis or salmon rickettsial septicaemia (SRS) in fish.

Abstract: The invention relates to cardio-protective agents. In particular, the present invention relates to cardio-protective extracts and fractions thereof prepared from kiwi fruit.

Abstract: The disclosure relates to outer membrane vesicles from Francisella and Piscirickettsia, and their use in vaccine compositions. In particular, the present disclosure relates to compositions and methods useful in inducing protective immunity against francisellosis or salmon rickettsial septicaemia (SRS) in fish.

Abstract: The invention relates to cardio-protective agents. In particular, the present invention relates to cardio-protective extracts and fractions thereof prepared from kiwi fruit.

Abstract: The present invention relates to polypeptides that bind to H3K4 methylated chromatin, and in particular to the use of reagents comprising such polypeptides for epigenetic/epigenomic analysis.

Abstract: The present invention relates ultrasound positioning systems (300), and in particular to ultrasound positioning systems that utilize at least one stationary array-based ultrasound transmitter (310) in combination with portable receivers (330,331) to provide a safe and robust positioning system.

Abstract: Provided herein are systems, uses, and processes relating to network communications. For example, provided herein are systems, uses, and processes for increasing transmission efficiency by removing redundancy from single source multiple destination transfers.

Abstract: A method of matching message elements, including a reading step of reading a contents of a first message and a second message and a determining step that determines whether the content of the first message is the same as the content of the second message, wherein if the content of the first message matches the content of the second message, a new pair is formed that includes the content of the first message and the content of the second message. The method further includes a matching table lookup step of reading a matching table, which stores one or more pairs of matching elements, a consistency check step to determine whether the new pair is consistent with the one or more pairs of matching elements stored in the matching table, and a storage step for storing the new pair to the matching table based on the result of the consistency check step.