Abstract: Described herein are compositions of an linoleic phospholipid for inhibiting inflammatory pathways or neurodegenerative processes. Also provided are uses of such compositions and methods of inhibiting inflammatory or neurodegenerative processes by administering a composition that includes an linoleic phospholipid and optionally a carrier to a cell, cell culture or subject in need of such treatment.
Abstract: A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence may be linked to the N-terminal, the C-terminal, or both the N-terminal and the C-terminal of the albumin amino acid sequence. Also provided is a nucleic acid molecule encoding the fusion protein and a vector comprising the nucleic acid molecule. Methods for treating or preventing cardiovascular or renal disease comprising administration of an effective amount of the fusion protein, or nucleic acid encoding the fusion protein, are also disclosed.
Type:
Grant
Filed:
October 20, 2006
Date of Patent:
August 30, 2011
Assignees:
University of Ottawa Heart Institute, McMaster University
Inventors:
Adolfo J. De Bold, Mercedes L. Kuroski De Bold, William Sheffield
Abstract: An expert system for assigning and tracking physical activity programs for patients with coronary artery disease provides user interfaces for recruiters who screen and enroll the patients as program participants in the physical activity programs; for coaches who monitor program participants and guide them through the physical activity program; and for program participants who create their own physical activity schedules,and log their physical activities. Expert system algorithms assign predefined physical activity programs to the program participants at predefined program milestones based on predefined criteria.
Type:
Application
Filed:
January 31, 2006
Publication date:
August 2, 2007
Applicant:
University of Ottawa Heart Institute
Inventors:
Robert Reid, Louise Morrin, Sophia Papadakis, Louise Beaton