Patents Assigned to University of Pittsbugh — Of the Commonwealth System of Higher Education
  • Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen
    Patent number: 7655461
    Abstract: The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility complex (MHC). The invention provides a method of activating a signaling pathway and/or killing a cancer cell using a receptor that is similar to or is a T cell receptor.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: February 2, 2010
    Assignee: University of Pittsbugh — Of the Commonwealth System of Higher Education
    Inventors: Olivera J. Finn, Nehad M. Alajez, Jan Schmielau, Mark D. Alter