Patents Assigned to University of Pittsburg-Of the Commonwealth System of Higher Education-Office of Technolology Manage
  • INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS
    Publication number: 20140199368
    Abstract: Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent or mitigate esophageal damage caused by radiation.
    Type: Application
    Filed: November 15, 2011
    Publication date: July 17, 2014
    Applicant: University of Pittsburg-Of the Commonwealth System of Higher Education-Office of Technolology Manage
    Inventors: Michael W. Epperly, Xiang Gao, Joel S. Greenberger, Song Li, Peter Wipf