Patents Assigned to University of Pittsburgh
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Publication number: 20240090810Abstract: A neurofeedback system includes an EEG apparatus, a presentation apparatus and a controller. The controller is configured to: (i) cause the presentation apparatus to display an overlaid image to the user that comprises a first image flickering at a first frequency and a second image flickering at a second frequency different than the first frequency, the first image being an affective distractor stimulus image and the second image being a task-relevant stimulus image, (ii) receive from the EEG apparatus a number of first steady-state visual evoked potential (SSVEP) signals generated in response the first image of the overlaid image and a number of second SSVEP signals generated in response the second image of the overlaid image, and (iii) calculate feedback indicative of how much attention of the was user allocated to the task-relevant stimulus image versus how much attention of the user was allocated to the affective distractor stimulus image.Type: ApplicationFiled: September 19, 2023Publication date: March 21, 2024Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC, NORTHEASTERN UNIVERSITYInventors: Mary L. Woody, Murat Akcakaya, Sarah Ostadabbas, Rebecca Price, Xiaofei Huang, Richard T. Gall, Anna Wears, Nastasia O. McDonald, Jennifer Mak
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Publication number: 20240091271Abstract: The present disclosure relates to the engraftment and proliferation of cells in fat-associated lymphoid clusters (“FALCs” or “milky spots”), which may be used to generate functional ectopic tissue. The present disclosure further provides methods and compositions for grafting and proliferating cells, in FALCs by activating the lymphotoxin beta receptor (LT?R) and/or NF-?B-inducing kinase (NIK) signaling pathway. The present disclosure also provides for methods and compositions to establish ectopic liver tissue in FALCs (milky spots) and to use such ectopic liver tissue for therapeutic benefit, and provides methods and compositions to generate ectopic kidney tissue in FALCs, which can be used in a subject for therapeutic benefit.Type: ApplicationFiled: August 23, 2023Publication date: March 21, 2024Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventor: Eric Lagasse
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Publication number: 20240093157Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: ApplicationFiled: November 15, 2023Publication date: March 21, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas Allen Nelson, Jr., Riccardo Gottardi
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Publication number: 20240083932Abstract: The invention includes a cationic cyclopentadienyliron dicarbonyl complex according to the general structure (I): wherein, Y is (CH2)n or (CH2)mA(CH2)n, A is O, NSO2R, S, or CR1R2, each of R, R1 and R2 with respect to A is independently alkyl or aryl, n is an integer from 1 to 8, m+n is an integer from 2 to 7, Z is alkyl, aryl, heteroaryl, or CF3, and X is BF4?, ClO4?, PF6?, AsF6?, or SbF6?.Type: ApplicationFiled: August 11, 2023Publication date: March 14, 2024Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: YIMING WANG, YIDONG WANG, RUIHAN WANG
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Publication number: 20240082430Abstract: Provided are ex vivo and in vivo methods utilizing therapeutic genes for treatment of male and female infertility, including non-obstructive azoospermia (NOA) and premature ovarian insufficiency (POI) and comorbid diseases, with or without transmitting the therapeutic gene to offspring of the infertile subject. Germline gene therapy methods are also described to reduce or eliminate disease from families with or without transmission of the therapeutic gene to offspring.Type: ApplicationFiled: August 28, 2023Publication date: March 14, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Kyle E. Orwig, Chatchanan Doungkamchan, Alexander N. Yatsenko, Aleksandar Rajkovic
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Publication number: 20240083979Abstract: Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.Type: ApplicationFiled: November 8, 2023Publication date: March 14, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Mark T. Gladwin, Jesus Tejero Bravo
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Publication number: 20240087750Abstract: h A method for using a trained machine learning model to predict risk of incident opioid use disorder (OUD) and/or of N an opioid overdose episode for a subject. The method comprises using at least one computer hardware processor to perform: accessing data associated with the subject, wherein the data comprises values for a plurality of predictors; generating input features for the trained machine learning model from the data; and providing the input features as input to the trained machine learning model to obtain an output indicative of the risk of OUD and/or of the opioid overdose episode for the subject, wherein the trained machine learning model comprises a first plurality of values for a respective first plurality of parameters, the first plurality of values used by the at least one computer hardware processor to obtain the output from the input features.Type: ApplicationFiled: June 17, 2021Publication date: March 14, 2024Applicants: University of Florida Research Foundation, Incorporated, University of Pittsburgh- Of the Commonwealth System of Higher Education, The United States Government as represented by The Department of Veterans AffairsInventors: Wei Hsuan Lo Ciganic, Walid Fouad Gellad
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Patent number: 11925611Abstract: The present disclosure is concerned with substituted N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds, and methods of treating and/or preventing neurodegenerative or neurocognitive disorders including, but not limited to, Alzheimer's disease, cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL), Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS/Lou Gehrig's disease), Multiple Sclerosis, spinal muscular atrophy, spinal and bulbar muscular atrophy, familial spastic paraparesis, Machado Joseph disease, Friedreich's ataxia, Lewy body disease, and dementia (e.g., vascular dementia, Lewy body dementia, frontotemporal dementia, mixed dementia, dementia induced by Alzheimer's disease or Parkinson's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: March 25, 2022Date of Patent: March 12, 2024Assignees: United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh - of the Commonwealth of Higher EducationInventors: Dandan Sun, Mohammad Iqbal Hossain Bhuiyan
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Publication number: 20240062564Abstract: A method of predicting cancer recurrence risk for an individual includes receiving patient spatial multi-parameter cellular and sub-cellular imaging data for a tumor of the individual, and analyzing the patient spatial multi-parameter cellular and sub-cellular imaging data using a prognostic model for predicting cancer recurrence risk to determine a predicted cancer recurrence risk for the individual, wherein the joint prognostic model is based on spatial correlation statistics among features derived for a plurality of intra-tumor spatial domains from spatial multi-parameter cellular and sub-cellular imaging data obtained from a plurality of cancer patients.Type: ApplicationFiled: October 24, 2023Publication date: February 22, 2024Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: SRINIVAS C. CHENNUBHOTLA, DOUGLASS L. TAYLOR, SHIKHAR UTTAM FNU
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Patent number: 11904069Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.Type: GrantFiled: April 4, 2018Date of Patent: February 20, 2024Assignees: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF CINCINNATIInventors: William R. Wagner, Sang-Ho Ye, Yingqi Chen, Vesselin Shanov
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Publication number: 20240054399Abstract: A system for providing a boosted decision tree (BDT) for use on an electronic device to provide an event score based on a user input event, where the device includes: a machine learning trainer configured to create a trained BDT from an untrained BDT by determining parameters for the untrained BDT; a nanosecond optimizer configured to create an optimized BDT, the nanosecond optimizer including at least one of a tree flattener, a tree merger, a score normalizer, a tree remover, and a cut eraser; and a converter coupled to the nanosecond optimizer and configured to receive the optimized BDT from the nanosecond optimizer and convert the optimized BDT to a language for high-level-synthesis to produce a hardware description language representation of the optimized BDT, wherein the hardware description language representation of the optimized BDT is structured and configured to be implemented in firmware provided on the electronic device.Type: ApplicationFiled: March 3, 2022Publication date: February 15, 2024Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: TAE MIN HONG, BENJAMIN T. CARLSON, JOERG H. STELZER, STEPHEN T. ROCHE, STEPHEN T. RACZ, DANIEL C. STUMPP, QUINCY BAYER, BRANDON R. EUBANKS
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Publication number: 20240050440Abstract: Triosephosphate isomerase deficiency (TPI Df) is a devastating childhood degenerative disease for which there are currently no treatments. Pathogenesis of this disease is driven by mutations that destabilize the TPI protein. A genome-wide RNAi screen in Drosophila to identify regulators of TPI stability is described. The screen identified 25 proteins that are critical to TPI stability, each of which has a human ortholog. Methods of promoting TPI protein stability and treating TPI Df in a subject by administering a therapeutically effective amount of an agent that inhibits expression or activity of one of the identified regulators are described. Also described is a method for the identification of agents capable of promoting stability of mutant TPI. Methods for treating a subject who has TPI Df by administering an agent that promotes stability of mutant TPI is also described.Type: ApplicationFiled: December 30, 2021Publication date: February 15, 2024Applicant: University of Pittsburgh - Of The Commonwealth System of Higher EducationInventors: Michael John Palladino, Stacy Lynn Hrizo, Andreas Vogt
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Publication number: 20240051931Abstract: The present disclosure is directed to chromane compounds, chromane compounds demonstrating HDAC inhibition, and pharmaceutical compositions thereof. Additional embodiments include methods of using the chromane compounds. For example, the disclosure includes methods of inhibiting histone acetylation in a cell, comprising contacting the cell with a chromane compound of the disclosure. Additional embodiments include methods of treating a disease capable of treatment by inhibition of histone acetylation in a patient in need thereof, comprising administering a chromane compound of the disclosure.Type: ApplicationFiled: December 2, 2021Publication date: February 15, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Peter Wipf, Donna M. Huryn, Matthew G. LaPorte, Leila Terrab, Michael James Houghton, Andrea Topacio, Taber Sarah Maskrey, Tyler Kristufek, Uygar Sozer, Desirae Lynn Crocker, Sipak Joyasawal, Alyssa Thornton, Shikha Singh Chauhan, Mary Liang, Prema Iyer, Jagannath Panda
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Publication number: 20240048184Abstract: Implants include a single tapped coil antenna having a first section and a second section for wireless power transfer, data downlink and data uplink. A modulated wireless power transfer signal is received by the tapped coil antenna and used to provide electrical power. The modulation is detected to generate downlink data. A switch is used to charge a section of the tapped coil antenna by establish a current which is then be interrupted by opening the switch. The switching produces a high-amplitude pulsed magnetic field (PMF) for use in data uplink over a large distance between the implant and an external transceiver.Type: ApplicationFiled: December 7, 2021Publication date: February 8, 2024Applicant: University of Pittsburgh – Of the Commonwealth System of Higher EducationInventors: Mingui Sun, Zhi-Hong Mao, Wenyan Jia, Tianfeng Wang, Qi Xu
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Publication number: 20240047033Abstract: Provided is a method of modelling a therapeutic response of a cancer cell or tumor, comprising: calculating a weight for each of a plurality of high-dimensional redundant multi-omics features that predict agent sensitivity or other clinical features based on statistical or machine learning methods; and calculating an integral genomic signature score for the cancer cell or tumor based on the weights, while algorithmically resolving the feature redundancy based on unlabeled genomic datasets for large cohorts of human tumors. Also provided is an iGenSig model for an agent that calculates the probability of response or resistance of a patient having a cancer or tumor to treatment with the agent. Also provided is a method for selecting a patient having a cancer or tumor for treatment with an agent. Further provided is a method of treating a patient having a cancer or tumor.Type: ApplicationFiled: December 16, 2021Publication date: February 8, 2024Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventor: XIAOSONG WANG
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Publication number: 20240041422Abstract: A system for monitoring free flap patency includes transmit and receive transducers structured to be coupled to a blood vessel, and a plurality of circuitry modules structured to insonify a blood flow volume within the blood vessel and receive a scattered signal from the receive transducer, extract a baseband Doppler blood flow signal, VBASEBAND, from the scattered signal, extract a plurality of features from VBASEBAND, and classify the plurality of features and generate a binary signal based on the classification of the plurality of features, wherein the binary signal will have a first state responsive to the classification of the plurality of features indicating that a flow rate within the blood vessel is less than a predetermined level and a second state responsive to the classification of the plurality of features indicating the flow rate within the blood vessel is greater than or equal to the predetermined level.Type: ApplicationFiled: October 11, 2023Publication date: February 8, 2024Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: MICHAEL A. ROTHFUSS, ERVIN SEJDIC, MICHAEL L. GIMBEL, MURAT AKCAKAYA
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Publication number: 20240016865Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.Type: ApplicationFiled: August 18, 2023Publication date: January 18, 2024Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH STSTEM OF HIGHER EDUCATIONInventors: Stephen Howard Thorne, Daniel J. Byrd
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Publication number: 20240011046Abstract: Oncolytic viruses encoding a recombinant form of TGF-? engineered to prevent homodimerization and recruitment of TGF-? receptor I are described. The engineered TGF-? monomers function as dominant-negative TGF-? inhibitors. Oncolytic viruses encoding a TGF-? monomer can be used for cancer immunotherapy to inhibit the immunosuppressive tumor microenvironment.Type: ApplicationFiled: August 27, 2021Publication date: January 11, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Greg M. Delgoffe, Andrew P. Hinck, Kristin DePeaux
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Publication number: 20240008753Abstract: Devices and methods for multi-parameter hemodynamic monitoring are provided. Determining a cardiac output of a patient using a cuff device includes measuring a cuff pressure waveform of a subject during inflation and/or deflation of the cuff device, computing systolic and diastolic blood pressure from the cuff pressure waveform using the cuff device, constructing a blood pressure waveform from the systolic and diastolic blood pressure and cuff pressure waveform using the cuff device, computing brachial artery compliance from the cuff pressure waveform, and computing the cardiac output from the blood pressure waveform and/or brachial artery compliance using the cuff device.Type: ApplicationFiled: July 7, 2023Publication date: January 11, 2024Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF MARYLANDInventors: Ramakrishna MUKKAMALA, Sanjeev Govinddas SHROFF, Michael R. PINSKY, Aman MAHAJAN, Kathirvel SUBRAMANIAM, Vishaal DHAMOTHARAN, Jin-Oh HAHN
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Publication number: 20240000326Abstract: Devices and methods for determining blood pressures are provided. In one example, a device for determining blood pressure of a subject includes a camera configured to measure a finger photo-plethysmography (PPG) waveform, an accelerometer configured to measure a vertical height of the device relative to a heart of a subject, an output device configured to guide the subject to raise a hand to vary the transmural pressure of an artery while maintaining a finger pressure on the camera, and a processor configured to compute pulse pressure of the subject from the finger PPG waveform and the vertical height, and display the pulse pressure on the screen.Type: ApplicationFiled: July 7, 2023Publication date: January 4, 2024Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Aman MAHAJAN, Ramakrishna MUKKAMALA, Feng XIONG, Mark A. FREITHALER, Sanjeev Govinddas SHROFF, Vishaal DHAMOTHARAN, Anand CHANDRASEKHAR