Abstract: The present application provides methods for the identification of somatic genome alterations with functional impact in the genome of a tumor. In several embodiments, the methods comprise generating a bipartite causal Bayesian network with maximal posterior probability including causal edges pointing from genes including somatic mutations and somatic copy number alterations in the genome of the tumor to genes having differential expression in the tumor. The methods can be used, for example, to identify driver somatic genome alterations in the genome of a tumor.
Type:
Grant
Filed:
November 13, 2017
Date of Patent:
May 21, 2024
Assignee:
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCAT
Abstract: A recombinant coronavirus vaccine is provided. Methods of making and delivering the coronavirus vaccine also are provided. A microneedle array is provided, along with methods of making and using the microneedle array.
Type:
Grant
Filed:
September 1, 2020
Date of Patent:
January 4, 2022
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Educat
Inventors:
Andrea Gambotto, Louis Falo, Jr., Eun Kim
Abstract: This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors such as meayamycin B or pladienolide derivative E7107) to increase viral vector (e.g., adeno-associated virus-based vector) infectivity are provided.
Type:
Grant
Filed:
June 12, 2015
Date of Patent:
December 28, 2021
Assignees:
Mayo Foundation for Medical Education and Research, University of Pittsburgh—Of the Commonwealth System of Higher Educat
Inventors:
Yasuhiro Ikeda, Claire A. Schreiber, Toshie Sakuma, Sara J. Holditch, Kazunori Koide