Patents Assigned to University of Pittsburgh of the Commonwealth System of Higher Education
  • Publication number: 20220017466
    Abstract: A compound, or a pharmaceutically acceptable salt or isomer thereof, of Formula I: wherein R is hydrogen, alkyl, substituted alkyl, alkenyl, or substituted alkenyl; R1 is hydrogen, alkoxy, or substituted alkoxy; R2 is hydrogen, alkyl, or substituted alkyl; and R3 is hydrogen, alkyl, or substituted alkyl.
    Type: Application
    Filed: June 25, 2021
    Publication date: January 20, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Universite Le Havre Normandie
    Inventors: Abdelhadi Rebbaa, Sebastien Comesse, Adam Daich, Martin Lawson, Catalin Pintiala
  • Publication number: 20210401884
    Abstract: The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating inflammatory and autoimmune related diseases, such as type 1 diabetes.
    Type: Application
    Filed: February 3, 2021
    Publication date: December 30, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Nick Giannoukakis, Massimo M. Trucco
  • Publication number: 20210402654
    Abstract: The presently disclosed subject matter relates to systems for making an implantable construct comprising a reservoir coupled to the at least one frame; a mandrel base coupled to the at least one frame; a mandrel coupled to the mandrel base; a first mechanism configured to be coupled to the at least one frame and configured to move the at least one frame along a first axis; a second mechanism configured to be coupled to the at least one frame and configured to rotate the least one mandrel base along a second axis between a first orientation and a second orientation; and a container configured to be coupled to the at least one frame and configured to receive the mandrel in the second orientation. The disclosed mechanisms can manually, semi-automatically, or automatically control the movements of the at least one frame, reservoir, mandrel, mandrel base, and container to produce the construct with a lumen. The presently disclosed subject matter also relates to methods for making the construct.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Alexander James Repko, Kacey Gribbin Marra, Benjamin Schilling
  • Publication number: 20210404989
    Abstract: A gas sensor (100,200) includes at least one sensor device including a surface acoustic wave (SAW) device (110) or a quartz crystal microbalance (QCM) device (210), and a layer of metal organic framework (MOF) material (120,220) disposed on each of the at least one sensor device. The at least one sensor device is structured to sense a change in mass of the MOF material.
    Type: Application
    Filed: January 26, 2018
    Publication date: December 30, 2021
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNITED STATES DEPARTMENT OF ENERGY
    Inventors: CHRISTOPHER E. WILMER, JENNA GUSTAFSON, PAUL R. OHODNICKI, JAGANNATH DEVKOTA
  • Publication number: 20210401941
    Abstract: Ophthalmic devices coated with an active agent eluting coating are provided herein. Placement of the coated ophthalmic devices on the surface of eye results in modulation of cells responding to an immune modifying agent and reducing inflammation-related complications in the eye. Methods for treating ocular disorders are also provided herein. The disclosed subject matter is based, in part, on the discovery that ophthalmic devices coated with a cytokine eluting coating can shift early-stage macrophage polarization associated with alleviation of symptoms and causes of inflammatory ocular disorders.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Mangesh Kulkarni, Alexis Nolfi, Bryan Nicklaus Brown, Vishal Jhanji
  • Publication number: 20210405038
    Abstract: The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically and selectively bind to the cardiac markers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the aptamer binds to the cardiac markers of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in electrochemical impedance is indicative of the presence of the cardiac markers of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic settings.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Prashant N. KUMTA, Mitali PATIL
  • Patent number: 11207369
    Abstract: Disclosed herein are methods for modifying ciliogenesis in one or more cells of a subject, the method comprising administering to the subject an effective amount of a composition comprising a Notch signaling inhibitor, wherein the modification results in an increase in a number of cilia, an increase in a length of cilia, and/or an increase in a beat frequency of cilia as compared to a control. Also disclosed herein are methods for modifying ciliogenesis in one or more cells of a subject, the method comprising administering to the subject from 0.1 ?g/kg to 100 g/kg of a Notch signaling inhibitor. In some embodiments, the methods can be used to treat Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Asthma, Primary Ciliary Dyskinesia (PCD), Cystic Fibrosis (CF), or hydrocephalus.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: December 28, 2021
    Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Maliha Zahid, Cecilia Wen Ya Lo
  • Publication number: 20210399248
    Abstract: Various light emitting diode device embodiments that include emissive material elements, e.g., core-shell quantum dots, that are either (i) provided in nanoscale holes provided in an insulating layer positioned between an electron supply/transport layer and a hole supply/transport layer, or (ii) provided on a suspension layer positioned above and covering a nanoscale hole in such an insulating layer. Also, various methods of making such light emitting diode devices, including lithographic and non-lithographic methods.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 23, 2021
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: HONG KOO KIM, DAUD HASAN EMON
  • Publication number: 20210395184
    Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: September 1, 2021
    Publication date: December 23, 2021
    Applicants: Complexa, Inc., University of Pittsburgh - of the Commonwealth System of Higher Education, Life Technologies Corporation
    Inventors: Bruce A. Freeman, Bruce Branchaud
  • Publication number: 20210388048
    Abstract: Recombinant C—X—C motif chemokine ligand (CXCL) peptides modified to introduce a cleavage site for a protease, such as a protease activated during an inflammatory response, are described. The CXCL peptides have the capacity to activate CXCR3 until being cleaved by the protease. Proteolytic cleavage of the CXCL peptide minimizes the pro-inflammatory response and inhibits the development of fibrosis.
    Type: Application
    Filed: October 18, 2019
    Publication date: December 16, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventor: Alan H. Wells
  • Publication number: 20210386852
    Abstract: A recombinant measles viral vector comprising a nucleic acid sequence encoding a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike glycoprotein is provided. Polypeptides comprising the SARS-CoV-2 spike glycoprotein also are provided, as well as related nucleic acids, vectors, and compositions. The polypeptides, nucleic acids, vectors, and compositions can be used in methods of preventing, inhibiting, reducing, eliminating, protecting, or delaying the onset of an infection or an infectious clinical condition caused by coronavirus and methods for inducing an immune response against a coronavirus.
    Type: Application
    Filed: January 7, 2021
    Publication date: December 16, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventor: William Paul Duprex
  • Publication number: 20210386825
    Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.
    Type: Application
    Filed: August 30, 2021
    Publication date: December 16, 2021
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Ri.MED Foundation
    Inventors: Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis
  • Publication number: 20210382073
    Abstract: The present disclosure relates to compositions and methods for identifying a subject at risk for traumatic brain injury. In particular, the instant disclosure is directed to identification of the levels of the proteins MMP-9 (Matrix Metallopeptidase 9), NSE (Neuron Specific Enolase) and VCAM-1 (Vascular Cell Adhesion Molecule 1) in a subject sample, and correlation of these protein levels with the presence of intracranial injury. In certain embodiments, subject age, gender and hemoglobin level are also correlated with the presence of intracranial injury.
    Type: Application
    Filed: August 20, 2021
    Publication date: December 9, 2021
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, AXELA, INC.
    Inventors: Rachel Berger, Patrick Kochanek, Brian J. Pak, Paul T. Smith, Mariya D. Kolesnikova, David Frederick Englert
  • Publication number: 20210379121
    Abstract: The present disclosure relates to probiotics and probiotic compositions having modified carbohydrate metabolism (e.g., modifying or metabolizing carbohydrates, or reduced glucose production), and thus regulating the absorption of the carbohydrates by the host subject. The present disclosure also relates to methods of making the probiotics and probiotic compositions. The present disclosure further relates to methods of regulating body weight in a subject, and methods of treating carbohydrate metabolism disorder, using the probiotics and probiotic compositions disclosed herein.
    Type: Application
    Filed: August 24, 2021
    Publication date: December 9, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Abhinav Prakash Acharya, Steven R. Little
  • Publication number: 20210383894
    Abstract: A method of generating a plurality of spatially co-registered data elements, each spatially co-registered data element being associated with and generated from a pair of co-registered tissue sections obtained from adjacent positions of a core taken from a tissue sample and including an image data section and a genomic data section. The method includes, for each pair of co-registered tissue sections: (i) obtaining and storing as part of a data element a plurality of multi to hyperplexed images from the imaging data section of the co-registered tissue section, (ii) generating and storing as part of the data element image data from the plurality of multi to hyperplexed images, and (iii) generating and storing as part of the data element genomic data from the genomic data section of the associated co-registered tissue section.
    Type: Application
    Filed: August 21, 2019
    Publication date: December 9, 2021
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: SRINIVAS C. CHENNUBHOTLA, ALBERT H. GOUGH, ANDREW M. STERN, MICHAEL J. BECICH, DOUGLASS L. TAYLOR
  • Publication number: 20210380666
    Abstract: Synthetic heme-containing molecules are described. The heme-containing molecules include a heme group bound to either two non-contiguous peptides or a single contiguous peptide via cysteine residues. Use of the synthetic heme-containing molecules, such as for the treatment of carboxyhemoglobinemia, cyanide poisoning and hydrogen sulfide (H2S) poisoning, is further described.
    Type: Application
    Filed: August 24, 2021
    Publication date: December 9, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Jason J. Rose, Jesus Tejero Bravo, Kazi R. Islam, Mark T. Gladwin, Raymond B. Yurko, Anthony W. DeMartino
  • Patent number: 11191785
    Abstract: The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of supplementing or reconstituting organ function. Tissues that may be propagated in this manner include but are not limited to lung, kidney, thyroid, intestine, and brain.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric Lagasse
  • Publication number: 20210369783
    Abstract: Ultrasound-guided rete testis injection/aspiration devices and methods are described. Some methods include inserting a needle into the rete testis space of a patient and injecting a therapeutic medium through the needle into the rete testis space and seminiferous tubules of the testis. The therapeutic medium can help to treat infertility. In some examples, the method can include monitoring intra-testicular pressure of the patient. In some examples, the therapeutic medium can include stem cells. In some examples, the therapeutic medium can include gene therapy vectors. In some examples, the method can include flushing the rete testis space and seminiferous tubules with a saline solution through the needle. Exemplary devices can include a dual lumen needle, a collection tube, a dual function pump, and flexible tubing. The dual function pump can include a dual syringe pump and a vacuum pump.
    Type: Application
    Filed: December 6, 2019
    Publication date: December 2, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Kyle E. Orwig, Hanna Valli-Pulaski
  • Publication number: 20210369914
    Abstract: The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also relates to methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, such as but not limited to, orthopedic, dental, craniofacial and cardiovascular surgery.
    Type: Application
    Filed: July 21, 2021
    Publication date: December 2, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: PRASHANT N. KUMTA, JINGYAO WU, OLEG VELIKOKHATNYI
  • Publication number: 20210371476
    Abstract: A chimeric antigen receptor is disclosed that includes: (a) an extracellular high affinity streptavidin; (b) a hinge domain from CD8; (c) a CD28 transmembrane domain; (d) an intracellular 4-1BB and/or CD28 signaling domain; and (e) an intracellular CD3 zeta signaling domain, wherein (a)-(e) are in N-terminal to C-terminal order. Nucleic acids encoding this chimeric antigen receptor, and T and natural killer (NK) cells transformed with this chimeric antigen receptor are also disclosed. The use of this chimeric antigen receptor for the treatment of tumors is also disclosed.
    Type: Application
    Filed: August 10, 2021
    Publication date: December 2, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventor: Jason Lohmueller