Patents Assigned to University of Pittsburgh of the Commonwealth System
  • METHOD AND APPARATUS FOR REPLACING DATA FROM NEAR TO FAR MEMORY OVER A SLOW INTERCONNECT FOR OVERSUBSCRIBED IRREGULAR APPLICATIONS
    Publication number: 20220197811
    Abstract: A data management method wherein a working set is distributed between near and far memories includes migrating first data from the far to the near memory according to a prefetcher algorithm. The first data (a subset of the working set) is maintained in the near memory in data structures according to predetermined semantics of the prefetcher that dictate that certain of the first data is prefetched when a first function evaluates as true. The method further includes detecting that the near memory has reached capacity, and in response, adaptively migrating a portion of the first data out of the near and into the far memory according to an eviction algorithm that is based on the set of prefetcher semantics such that certain of the portion of the first data is evicted when a second function evaluates as true, wherein the second function equals the inverse of the first function.
    Type: Application
    Filed: April 17, 2020
    Publication date: June 23, 2022
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Debashis Ganguly, Rami G. Melhem, Ziyu Zhang, Jun Yang
  • MODIFIED HEMOGLOBIN MOLECULES AND USES THEREOF
    Publication number: 20220185867
    Abstract: Compositions that include a globin, such as hemoglobin, in a relaxed state are described. Globin molecules in a relaxed state (R state) have a higher binding affinity for carbon monoxide and oxygen than globin molecules in a tense state (T state). Hemoglobin in a relaxed state can be, for example, hemoglobin that is substantially free of 2,3-diphosphoglycerate or hemoglobin that includes a ?-Cys93 that is covalently modified to inhibit one or both salt bridges between ?-Asp94, ?-His146 and ?-Lys40. Methods for using these compositions, such as for treating carbon monoxide poisoning, and methods for producing these compositions, are also disclosed.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 16, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Anthony W. DeMartino, Jason J. Rose, Qinzi Xu, Mark T. Gladwin, Jesus Tejero Bravo
  • MULTIVALENT VACCINES DERIVED FROM KLEBSIELLA OUT MEMBRANE PROTEINS
    Publication number: 20220160857
    Abstract: The present disclosure describes multivalent antibacterial vaccines for the treatment of bacterial infections, such as Klebsiella, E. coli and E. cloacae, as well as therapy-resistant forms thereof.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 26, 2022
    Applicants: The Administrators of the Tulane Educational Fund, University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Jay KOLLS, Elizabeth NORTON, Kong CHEN
  • HIP JOINT TETHER DEVICE
    Publication number: 20220160511
    Abstract: Hip tethering devices comprise a femoral implant including a housing that anchors the femoral implant to the femur, at least one spring, and a slider, such that the slider can move relative to the housing via compression and expansion of the at least one spring. A tether has a first end that anchors to the acetabulum, the tether passes through the femoral head, and a second end couples to the slider of the femoral implant, such that the tether spans across the patient's hip joint and relative motion between the slider and the housing allows a limited degree of separation of the femoral head from the acetabulum, while the at least one spring applies a variable tension load to the tether that resists separation of the femoral head from the acetabulum.
    Type: Application
    Filed: April 15, 2020
    Publication date: May 26, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventor: Patrick Peter Bosch
  • SUPER ELASTIC, BIOABSORBABLE ENDOVASCULAR DEVICES
    Publication number: 20220160526
    Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.
    Type: Application
    Filed: December 2, 2020
    Publication date: May 26, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: YOUNGJAE CHUN, WILLIAM R. WAGNER, XINZHU GU, PETER DREW WEARDEN, TOMO YOSHIZUMI
  • AUTOLOGOUS THYMIC TISSUE TRANSPLANTATION
    Publication number: 20220152114
    Abstract: The present disclosure provides methods and kits for preserving or restoring thymic functions of a subject in need thereof. The methods and kits disclosed herein include delivering an autologous thymic tissue into at least one lymph node of the subject.
    Type: Application
    Filed: February 4, 2022
    Publication date: May 19, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric LAGASSE
  • TOUCH PROBE PASSIVELY POWERED WIRELESS STENT ANTENNA FOR IMPLANTED SENSOR POWERING AND INTERROGATION
    Publication number: 20220151493
    Abstract: A system and method for wirelessly and passively powering and/or interrogating an implanted stent using a touch probe assembly through a near-field electrical connection not over an air interface. The stent apparatus includes at least one stent member functioning as an antenna and an electronics module coupled to the at least one stent member. Also, a wirelessly and passively powered power meter for use with implanted stents. The power meter includes an electronics module coupled to a stent member, wherein the electronics module includes a programmable oscillator structured to generate an oscillating signal that is proportional to an amount of AC power received by the implantable stent apparatus power meter through the stent member.
    Type: Application
    Filed: February 3, 2022
    Publication date: May 19, 2022
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: MICHAEL A. ROTHFUSS, ERVIN SEJDIC, MICHAEL L. GIMBEL
  • METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    Publication number: 20220143133
    Abstract: It is an object of the present invention to provide methods and compositions for protection of subjects from acute kidney injury by treating the subject with compounds that modulate the cell cycle. Modulating the cell cycle can comprise inducing G0/G1 cell cycle arrest, and/or inducing cell cycle progression. As demonstrated below, even a single administration of a compound which induces G0/G1 cell cycle arrest can protect subjects from AKI, and may be used prophylactically in advance of, or as a treatment following, various treatments or conditions that are known to be injurious to the kidney, followed optionally by release of the arrest. Once AKI is established, cell cycle progression can be induced to increase replacement of lost and damaged cells.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 12, 2022
    Applicants: ASTUTE MEDICAL, INC., UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: PAUL MCPHERSON, JOHN A. KELLUM
  • 20-HETE FORMATION INHIBITORS
    Publication number: 20220144797
    Abstract: This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 12, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Lee Apostle McDermott, David Koes, Samuel M. Poloyac, Shabber Mohammed
  • ACOUSTIC EXTRACELLULAR MATRIX HYDROGELS AND THEIR USE
    Publication number: 20220143265
    Abstract: Methods are disclosed herein for producing a mammalian acoustic extracellular matrix (ECM) hydrogel. In further embodiments, mammalian acoustic ECM hydrogels are disclosed that are produced using the disclosed methods. Also disclosed is a mammalian acoustic ECM hydrogel, wherein the hydrogel is thermoreversible. Methods of using these acoustic ECM hydrogels are also disclosed.
    Type: Application
    Filed: March 12, 2020
    Publication date: May 12, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Stephen Francis Badylak, George S. Hussey
  • ONCOLYTIC VIRUSES TARGETING STAT3
    Publication number: 20220133824
    Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
    Type: Application
    Filed: January 13, 2022
    Publication date: May 5, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Stephen Howard Thorne, Daniel J. Byrd
  • PDLIM2 AS A BIOMARKER FOR CANCER AND AS AN ANTI-CANCER TREATMENT TARGET
    Publication number: 20220135634
    Abstract: The present disclosure provides methods and compositions for treating cancer (e.g., lung cancer) in a subject by increasing the expression of PDZ-LIM domain containing protein 2 (PDLIM2) in the subject, or a functional fragment thereof. The present disclosure further provides methods of using PDLIM2 as a marker for determining and monitoring a subject's responsiveness to an anti-cancer treatment, providing a prognosis about a cancer in a subject, and selecting an effective anti-cancer treatment for a subject. The present disclosure also provides in vitro methods of screening anti-cancer agents by assessing whether the expression of PDLIM2 is restored by an anti-cancer agent in a cancer cell.
    Type: Application
    Filed: January 14, 2022
    Publication date: May 5, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Zhaoxia QU, Gutian XIAO
  • ONE-STEP GENE THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY VIA GENE REPLACEMENT AND ANTI-INFLAMMATION
    Publication number: 20220136005
    Abstract: In one embodiment, the invention provides a dual-cassette gene vehicle comprising cassettes for expression of both a mini-dystrophin gene and NF-?B/p65-shRNA gene in cardiac muscle tissue and skeletal muscle tissue, which is an adeno-associated viral (AAV) vector, wherein the mini-dystrophin gene is operably linked to a construct comprising a muscle-specific first promoter and a modified Mcken (MCK) enhancer and wherein the NF-?B/p65-shRNA gene is under the control of a second promoter. Also are provided pharmaceutical compositions comprising such gene vehicles and a method for ameliorating Duchenne muscular dystrophy (DMD) employing such gene delivery vehicles and pharmaceutical compositions.
    Type: Application
    Filed: February 3, 2020
    Publication date: May 5, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Bing WANG, Freddie FU
  • ONCOLYTIC VIRUSES TARGETING STAT3
    Publication number: 20220133825
    Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
    Type: Application
    Filed: January 13, 2022
    Publication date: May 5, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Stephen Howard Thorne, Daniel J. Byrd
  • TREATMENT OF OCULAR CONDITIONS UTILIZING A HISTONE/PROTEIN DEACETYLASE INHIBITOR
    Publication number: 20220125729
    Abstract: A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent is a histone deactylase inhibitor.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 28, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Steven R. Little, Michelle L. Ratay
  • USE OF OVARIAN-DERIVED HYDROGELS FOR RESTORATION OF REPRODUCTIVE FUNCTION AND HEALTH IN WOMEN
    Publication number: 20220125856
    Abstract: The present disclosure provides methods for restoring reproductive health and/or fertility in a subject by delivering immature follicles to the subject using an ovarian-derived hydrogel. The present disclosure also provides methods for treating ovarian-associated diseases using ovarian-derived hydrogels or their derivatives for delivery of therapeutic agents to the subject in need thereof. The present disclosure further provides kits for restoring reproductive health and/or fertility, and kits for treating ovarian-associated diseases.
    Type: Application
    Filed: December 30, 2021
    Publication date: April 28, 2022
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC
    Inventors: Michael Joseph BUCKENMEYER, Kyle E. ORWIG, Bryan Nicklaus BROWN, Meena SUKHWANI
  • METHODS OF TREATMENT USING PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE
    Publication number: 20220112179
    Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, National Institutes of Health, A Component of the United States Department of Health and Human Servi, The Regents of the University of California
    Inventors: Donna M. Huryn, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neitz, Kean-Hooi Ang, Clifford Bryant, Stacie Bulfer
  • CO2 HYDROGENATION AND FISCHER-TROPSCH TO OLEFINS CATALYST
    Publication number: 20220111361
    Abstract: The invention relates to nanocatalysts composed of iron oxide nanoparticles supported on porous interconnected carbon nanosheets (CNS) fabricated from the carbonization of potassium citrate, that are remarkably active for CO2 hydrogenation and Fischer-Tropsch to Olefins (FTO) synthesis, as well as a method for directly converting CO2 and H2 to C2-C4 olefins and direct FTO synthesis.
    Type: Application
    Filed: January 13, 2020
    Publication date: April 14, 2022
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, NATIONAL ENERGY TECHNOLOGY LABORATORY (NETL)
    Inventors: Sittichai NATESAKHAWAT, Christopher MATRANGA, Douglas KAUFFMAN, Congjun WANG, Yunyun ZHOU
  • NEUROPROTECTIVE PEPTIDES AND METHODS OF THEIR USE
    Publication number: 20220106360
    Abstract: Neuroprotective peptides derived from the voltage-gated potassium channel Kv2.2 are described. The peptides promote dispersal of the cognate channel Kv2.1 in neurons, thereby blocking pro-apoptotic potassium efflux, and preserving cell viability after apoptotic injury. Methods of preventing and treating neuronal damage, such as neuronal damage following ischemic stroke, by administering the neuroprotective peptides are described. Fusion of the neuroprotective peptides to a cell-penetrating peptide to promote cellular uptake is also described.
    Type: Application
    Filed: October 5, 2021
    Publication date: April 7, 2022
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Elias Aizenman, Jason Arnold Justice, Anthony John Schulien
  • Toilet seat wrap
    Patent number: D950690
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: May 3, 2022
    Assignees: United States Government as Represented by the Department of Veterans Affairs, University of Pittsburgh - Of The Commonwealth System Of Higher Education
    Inventors: Rory A. Cooper, Rosemarie Cooper