Abstract: A method for obtaining a taxane by which a taxane is isolated from a growth medium, such as soil, pumice, perlite, rocks, and/or gravel in which a taxane-producing plant has grown. A method for obtaining a taxane by which a taxane is isolated from water effluent from plantings of living plants (e.g. a yew tree) that produce a taxane have grown in a growth medium, such as soil, pumice, perlite, rocks, and/or gravel.
Abstract: A method for selecting test site locations on a substrate, by a) specifying a subset of all test site locations on the substrate, and b) selecting a desired number of candidate test site locations from within the subset of test site locations on the substrate. c) While selecting one of the candidate test site locations and holding all others of the candidate test site locations as fixed, determining a new location for the selected one of the candidate test site locations, which new location increases a test sensitivity, as estimated by a trace of a variance-covariance matrix. d) Repeating step (c) for each candidate test site location in the subset of test site locations, to produce a finalized set of candidate test site locations, until a desired end point is attained.
Type:
Grant
Filed:
April 28, 2005
Date of Patent:
October 2, 2007
Assignees:
State of Oregon University Portland State, LSI Corporation
Inventors:
Bruce J. Whitefield, Paul J. Rudolph, James N. McNames, Byungsool Moon
Abstract: A method for obtaining a taxane by which a taxane is isolated from a growth medium, such as soil, in which a taxane-producing plant has grown.
Abstract: Methods for obtaining taxanes from novel sources are disclosed. Angiosperms other than hazelnut and the gymnosperm ginkgo have been discovered to be sources of taxane, including paclitaxel. Taxane may also be obtained from fungal endophytes from these plants. Methods for optimizing the recovery of taxane from plant sources are disclosed in which a plant part is surface-sterilized before extracting taxane therefrom or before culturing fungal endophytes therefrom.
Abstract: A bicycle storage rack has substantially straight, horizontally extending upper and lower anchoring members that extend generally parallel to one another and are secured to building members such as a floor, wall or ceiling. A row of vertically extending bicycle support members are connected to the upper and lower anchoring members with the support members being spaced apart from one another to provide a series of bicycle receiving gaps therebetween. Hangers or hooks are provided on at least some of the bicycle support members to support bicycles, hung by a wheel rim, at an elevation above the floor.
Abstract: Taxol, an antineoplastic drug, has shown cytotoxic activity against numerous malignant tumors including: breast cancer, colon cancer, ovarian cancer, and skin cancer. Taxol is found in many species of yew including: slow-growing Taxus brevifolia and faster-growing Taxus media X Hicksii. Yew tree cuttings were cultured and the medium was extracted weekly, bi-weekly, and tri-weekly over a period of nine weeks. Taxol and other taxanes were separated through a multi-step procedure using hexane extractions, C-18 Sep Pak cartridges, and high performance liquid chromatography (HPLC). The concentration of the taxanes was then calculated. Taxol and other taxanes can continue to be transferred into a culture medium and extracted over a nine-week period. There is a higher yield when extracted weekly.
Type:
Grant
Filed:
February 17, 1995
Date of Patent:
April 15, 1997
Assignee:
University of Portland
Inventors:
Angela Hoffman, Courtney C. J. Voelker, Alyssa T. Franzen