Abstract: A hand-portable test apparatus includes an in-the-field test processing assembly, and a lab-on-a-chip test cartridge having a neutralising zone, a specific reagent mixing zone, and a testing chamber. It has a convective heating loop for thermal cycling. There are two passive self-actuating valves that allow the test chamber volume to fill with solution, but then close to meter and trap the solution. The apparatus has external illumination ports, and an optical sensing port. Each cartridge is uniquely identified. It has smooth surfaces that allow adhesive membranes to be used to permit the pre-loading of reagents, prevent evaporation, and permit preservation of results. The test apparatus includes a holder for the cartridge with a heater, illumination, and optical sensor units closely positioned relative to the holder. There is a wiring circuit board, a processor, and a power supply. All of the items are contained within a unitary housing.

Abstract: Described herein are combinations useful for treating or preventing a cardiometabolic disease or disorder, or which can be used for appetite suppression, for improvement of endothelial function, for controlling weight, or a combination of one or more thereof. The combinations comprise Berberine, alpha lipoic acid (LA), and apocynin, or an isomer, derivative, pharmaceutically acceptable salt or ester of one or more thereof. Methods of treatment using the combinations, as well as compositions and related medical uses are also described.

Abstract: Described herein is an apparatus and method for ischemic muscle training or recovery by coordinated blood flow restriction and electrical muscle stimulation. The apparatus comprises a blood flow occluding element for restricting blood flow to a target muscle or muscle group in a user, and measuring resting systolic blood pressure (SBP); and an electrical muscle stimulator comprising at least one electrode and a control unit which, upon activation, is effective to send low amplitude electric pulses through the target muscle or muscle group forcing the targeted muscle to contract while the blood flow is restricted.

Abstract: The present application relates to novel apocynin-lipoic acid covalent conjugates, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions that are mediated by oxidative stress. In particular, the present application includes compounds of Formula (I), and compositions and uses thereof.

Abstract: A method and a corresponding system for obtaining a serum mid-infrared spectroscopic profile using Fourier-transform infrared spectroscopy (FTIR) are described. The method comprises acquiring FTIR spectra for dried sera and preprocessing the FTIR spectra of sera by differentiation and smoothing to enhance weak spectral features and to remove baseline variations. The preprocessed FTIR spectra are normalized to a common intensity range, the normalization being performed in a spectral sub-region defined by strongest infrared (IR) absorption for a protein to obtain the serum spectroscopic profile. The serum spectroscopic profiles provide a basis to diagnose immunoglobulin disorders or to quantify serum immunoglobulin levels.

Abstract: Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

Abstract: Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

Abstract: A feeder for poultry comprising a feed tray, a feed supply stack secured on the tray and audio conveying means to facilitate dispersion of feeding behavior enhancing sounds from the stack a feeding period.

Abstract: The invention provides a method and apparatus for remote sensing of livestock, using a thermographic image sensing system, in order to determine one or more of the number, weight, location, temperature, carcass pH, etc., of animals in a surveillance area. A thermographic image comprising pixels of the area is sent to a digitizing board in a microcomputer, where the image is converted into a number array. The numbers are then interpreted by software to provide the desired information in a decipherable form.