Patents Assigned to University of Puerto Rico
  • Patent number: 8986012
    Abstract: The 3D visualization kit helps visualize concepts relating to points, surfaces, planes, curves, contours, and vectors in three dimensions. The kit is an inexpensive solution provided along with accompanying materials for its use that will allow students to effectively visualize concepts in three dimensions and aid in understanding important calculations in multivariable calculus eliminating the abstraction normally associated with concepts in three dimensions.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: March 24, 2015
    Assignee: University of Puerto Rico
    Inventor: Daniel L. McGee
  • Patent number: 8945494
    Abstract: The invention provides a simple an efficient method for the synthesis of CaS nanoparticles, where a solution of CaAc in DMSO is warmed in a microwave oven.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: February 3, 2015
    Assignee: University of Puerto Rico
    Inventors: Miguel E. Castro, Daniel Rivera
  • Patent number: 8932384
    Abstract: The invention described relates to the synthesis of gold nanorods in high concentrations in a single batch and their use in detection of nitroexplosives using Surface Enhanced Raman Spectroscopy (SERS). The nanoparticle suspensions were stable up to a month after preparation. The aggregated nanorods have a strong SERS effect for nitroexplosives (3,5-dintro-4-methylbenzoic acid and 2,4,6-TNT) with sensitivity of 5.0 pg in a few seconds. The results obtained in numerous tests demonstrated a high reproducibility that makes aggregated nanorods very attractive substrates for defense and security applications.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: January 13, 2015
    Assignee: University of Puerto Rico
    Inventors: Samuel P. Hernandez-Rivera, Oliva M. Primera-Pedrozo, Ana M. Chamoun-Emanuelli, Wilmarie Medina-Ramos
  • Patent number: 8884006
    Abstract: A novel inhibitor of Rac activity based on the structure of the established Rac/Rac-GEF inhibitor NSC23766 is discloses. The compound EHop-016, with an IC50 of 1.1 ?M, is a 100-fold more efficient inhibitor of Rac activity than NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations ?5 mM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. In MDA-MB-435 cells, EHop-016 (?5 mM) inhibits the association of the Rac-GEF Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. EHop-016 does not affect the association of the Rac-GEF Tiam-1 with Rac1(G15A) at similar concentrations. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac-downstream effects of p21-activated kinase (PAK)1 activity and directed migration of metastatic cancer cells. At low concentrations (<5 ?M), EHop-016 does not affect cell viability.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: November 11, 2014
    Assignee: University of Puerto Rico
    Inventors: Eliud Hernandez, Cornelis Vlaar, Suranganie Dharmawardhane
  • Publication number: 20140273161
    Abstract: The invention provides a system of heavy metal sequestration by bacteria. The bacteria expresses the ppk, mt, and/or ?-galactosidase (lacZ) genes and can tolerate at least 25 ?M mercury, 1,000 ?M zinc, 250 ?M cadmium, and 3,000 ?M Pb. The system allows for facile determination of the presence of heavy metal contaminants in a liquid and the facile collection of the bacteria that has sequestered large amounts of heavy metal. Further provided is a system of gene expression in bacteria that comprises phage and plastid gene expression elements and delivers a particularly high level of protein expression and heavy metal resistance.
    Type: Application
    Filed: May 30, 2014
    Publication date: September 18, 2014
    Applicant: Inter American University of Puerto Rico
    Inventor: Oscar N. Ruiz
  • Patent number: 8835861
    Abstract: The invention utilizes the changes in physical properties of materials during a solid-solid phase transition in order to actuate microactuators. The substantial changes in properties during insulator-to-metal transitions (IMTs) of some materials are useful for controlling purposes. Methods of using the microactuators are also explained.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: September 16, 2014
    Assignee: University of Puerto Rico
    Inventors: Rafmag Cabrera, Felix E. Fernandez, Armando Rua, Nelson Sepulveda
  • Patent number: 8821353
    Abstract: The invention provides a mobile structure that can be used in any water body having a relatively uniform floor and a calm surface (i.e., beach, lake or pool). This structure has multiple hold and leaning surfaces and/or elements that lie flush and below the water level providing people with disabilities and older people a solid support structure to hold, sit, stand or lean while performing adapted swimming activities.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: September 2, 2014
    Assignee: University of Puerto Rico
    Inventors: Mauricio A. Lizama, Diego A. Agostini
  • Patent number: 8803264
    Abstract: The invention provides a novel class of room-temperature, single-phase, magnetoelectric multiferroic (PbFe0.67W0.33O3)x (PbZr0.53Ti0.47O3)1-x (0.2?x?0.8) (PFWx?PZT1-x) thin films that exhibit high dielectric constants, high polarization, weak saturation magnetization, broad dielectric temperature peak, high-frequency dispersion, low dielectric loss and low leakage current. These properties render them to be suitable candidates for room-temperature multiferroic devices. Methods of preparation are also provided.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: August 12, 2014
    Assignee: University of Puerto Rico
    Inventors: Ram S Katiyar, Ashok Kumar, James F Scott
  • Patent number: 8784766
    Abstract: Iron nanoparticles were employed to induce the synthesis of diamond on molybdenum, silicon, and quartz substrates. Diamond films were grown using conventional conditions for diamond synthesis by hot filament chemical vapor deposition, except that dispersed iron oxide nanoparticles replaced the seeding. This approach to diamond induction can be combined with dip pen nanolithography for the selective deposition of diamond and diamond patterning while avoiding surface damage associated to diamond-seeding methods.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: July 22, 2014
    Assignee: The University of Puerto Rico
    Inventors: Kishore Uppireddi, Gerardo Morell, Brad R. Weiner
  • Patent number: 8785174
    Abstract: The invention provides a system of heavy metal sequestration by bacteria. The bacteria expresses the ppk, mt, and/or ?-galactosidase (lacZ) genes and can tolerate at least 25 ?M mercury, 1,000 ?M zinc, 250 ?M cadmium, and 3,000 ?M Pb. The system allows for facile determination of the presence of heavy metal contaminants in a liquid and the facile collection of the bacteria that has sequestered large amounts of heavy metal. Further provided is a system of gene expression in bacteria that comprises phage and plastid gene expression elements and delivers a particularly high level of protein expression and heavy metal resistance.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: July 22, 2014
    Assignee: Inter American University of Puerto Rico
    Inventor: Oscar N. Ruiz
  • Patent number: 8622166
    Abstract: The present invention provides a universal single switch driving system for power wheelchairs, which can be attached to any wheelchair joystick and remotely controlled, by any single switch available for persons with disabilities.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: January 7, 2014
    Assignee: University of Puerto Rico
    Inventors: Raul Edmir Torres-Muniz, Sergio E. Garcia-Vegara, Baldin Lorens-Bonilla, Daphne Sanchez-Cordero, Mauricio Lizama
  • Patent number: 8608850
    Abstract: Diamond thin films were deposited on copper substrate by the Vapor Solid (VS) deposition method using a mixture of fullerene C60 and graphite as the source material. The deposition took place only when the substrate was kept in a narrow temperature range of approximately 550-650° C. Temperatures below and above this range results in the deposition of fullerenes and other carbon compounds, respectively.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: December 17, 2013
    Assignee: The University of Puerto Rico
    Inventors: Deepak Varshney, Gerardo Morell, Brad R. Weiner, Vladimir Makarov
  • Patent number: 8524685
    Abstract: Preparation of nano-conjugated Tunicamycin enhances the efficacy of the drug Tunicamycin. The invention provides several nanoformulations such as Tunicamycin encapsulated in peptide nanotubes, nanotubes bound to gold nanoparticles conjugated with Tunicamycin, Tunicamycin conjugated with nanotubes, gold nanoparticles bound to tubes and conjugated with Tunicamycin, and gold nanoparticles conjugated with Tunicamycin.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: September 3, 2013
    Assignee: University of Puerto Rico
    Inventor: Dipak K Banerjee
  • Patent number: 8491964
    Abstract: The invention presents a simple, non-destructive and non-abrasive method of diamond nucleation using polyethene. It particularly describes the nucleation of diamond on an electrically viable substrate surface using polyethene via chemical vapor deposition (CVD) technique in a gaseous environment.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: July 23, 2013
    Assignee: University of Puerto Rico
    Inventors: Gerardo Morell, Vladimir Makarov, Deepak Varshney, Brad Weiner
  • Publication number: 20130172552
    Abstract: A novel inhibitor of Rac activity based on the structure of the established Rac/Rac-GEF inhibitor NSC23766 is discloses. The compound EHop-016, with an IC50 of 1.1 ?M, is a 100-fold more efficient inhibitor of Rac activity than NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations ?5 mM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. In MDA-MB-435 cells, EHop-016 (?5 mM) inhibits the association of the Rac-GEF Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. EHop-016 does not affect the association of the Rac-GEF Tiam-1 with Rac1(G15A) at similar concentrations. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac-downstream effects of p21-activated kinase (PAK)1 activity and directed migration of metastatic cancer cells. At low concentrations (<5 ?M), EHop-016 does not affect cell viability.
    Type: Application
    Filed: September 18, 2012
    Publication date: July 4, 2013
    Applicant: UNIVERSITY OF PUERTO RICO
    Inventor: University of Puerto Rico
  • Patent number: 8440973
    Abstract: The invention utilizes the changes in physical properties of materials during a solid-solid phase transition in order to enhance the sensitivity of cantilever IR detectors. The substantial changes in properties during insulator-to-metal transitions (IMTs) of some materials are useful for controlling purposes according to the invention. A cantilever arrangement is provided with a cantilever being coated with an insulator-to-metal transitions (IMTs) material. Bending of the cantilever is achieved when the temperature of the (IMTs) material is within its phase transition temperature range. A Focal Plane Array (FPA) for detecting Infrared (IR) radiation including the cantilever arrangement of the invention is also proposed.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: May 14, 2013
    Assignee: University of Puerto Rico
    Inventors: Felix E Fernandez, Nelson Sepulveda-Alancastro, Armando Rua, Rafmag Cabrera
  • Patent number: 8440166
    Abstract: A titanium silicate variant named UPRM-5 was prepared using tetraethylammonium hydroxide as a structure-directing agent (SDA). Successful detemplation was achieved via ion exchange with NH4Cl. Effective functionalization was obtained after ion exchanging the detemplated material using SrCl2 and BaCl2. Adsorption of CO2 at 25° C. in Sr- and Ba-UPRM-5 materials activated at different temperatures. For low partial pressures, the observed CO2 adsorption capacities increased as follows: NH4-UPRM-5<Sr-UPRM-5<Ba-UPRM-5. Both the Sr- and Ba-UPRM-5 materials exhibited outstanding selectivity for CO2 over CH4, N2 and O2.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: May 14, 2013
    Assignee: University of Puerto Rico
    Inventors: Arturo Hernandez-Maldonado, Jose N Primera-Pedrozo
  • Patent number: 8383674
    Abstract: Silver nanoclusters were synthesized by reducing silver nitrate with ethylene glycol at a certain temperature in the presence of zeolite. A one-pot procedure rendered uniform size distributions of quasi-spherical silver clusters synthesized on the surfaces of cubic-like zeolite.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: February 26, 2013
    Assignee: University of Puerto Rico
    Inventor: Yury Posada
  • Patent number: 8268628
    Abstract: The invention describes a method for determining aggregation in protein, peptide or peptoid formulation, without the use of probes or additives. The method uses FTIR spectroscopy combined with the two-dimensional correlation analysis (2DCOS) which allows for the determination of the presence of aggregates, the determination of the mechanism of aggregation, allowing for correction in the pipeline manufacturing process of the protein to once again generate viable protein. In addition, the thermal transition of the protein can also be determined and a 2DCOS plot generated to compare with the established viable protein, allowing for quality control, stability and viability of the desired protein product. The ease of sample preparation and data analysis allows for the automation of this method.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: September 18, 2012
    Assignee: University of Puerto Rico
    Inventors: Belinda Pastrana-Rios, Ibon LLoro-Manzano
  • Patent number: 8185982
    Abstract: A bathing chair which has a water-spraying function for simultaneously effecting a shower discharge from each of a plurality of shower discharge ends and thus assist a person with severe disabilities while cleansing him or herself or while being assisted by a third person. The bathing chair including strategically located nozzles to wash critical body parts, a main control system with manual and electro-mechanical operated valves, two main flow paths with independent control systems, means for combining a soap product and water, a water temperature sensor, and a pump/reservoir system for water pressure adjustment.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: May 29, 2012
    Assignee: University of Puerto Rico
    Inventors: Mauricio A Lizama, Gustavo E Frank-Ayala, Nestor M Martinez, Jose J Mayi, David Serrano