Patents Assigned to University of Queensland
  • Publication number: 20220342022
    Abstract: A training method for training neural networks to determine a magnetic susceptibility distribution of a sample may include: storing a simulated magnetic susceptibility map of the sample, generating a modified magnetic susceptibility map by combining an influence of one or more external magnetic susceptibility sources with the simulated magnetic susceptibility map and storing the modified magnetic susceptibility maps. The method may include generating a first training image by applying a quantitative susceptibility mapping model the modified magnetic susceptibility map and storing the first training image, applying the first neural network to the first image and a second neural network to an output of the first neural network and changing network parameters of the first and the second neural network depending on a deviation of an output of the second artificial neural network from the simulated magnetic susceptibility map.
    Type: Application
    Filed: April 21, 2022
    Publication date: October 27, 2022
    Applicants: Siemens Healthcare GmbH, The University of Queensland
    Inventors: Kieran O'Brien, Jin Jin, Steffen Bollmann, Markus Barth, Francesco Cognolato
  • Patent number: 11434190
    Abstract: Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: September 6, 2022
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Mathias Francois, Johannes Zuegg, Jeroen Overman, Sreeman Kumar Mamidyala, Angela Aguslyarti Salim, Frank Roger Fontaine, Matthew Allister Cooper, Robert John Capon, Avril Alexis Barbara Robertson
  • Patent number: 11369809
    Abstract: The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 28, 2022
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Juergen Goetz, Gerhard Leinenga
  • Patent number: 11345717
    Abstract: An optical sensing element for use in the detection of hydrogen peroxide includes a sensing compound provided as a coating on a substrate. The sensing compound, on exposure to hydrogen peroxide, forms a luminescent reporter compound when excited with stimulating radiation at a predetermined wavelength that the sensing compound does not absorb.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 31, 2022
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Paul Leslie Burn, Paul Edward Shaw, Shengqiang Fan
  • Patent number: 11345599
    Abstract: Particulate material comprising rough mesoporous hollow nanoparticles. The rough mesoporous hollow nanoparticles may comprise a mesoporous shell, the external surface of which has projections thereon, the projections having smaller sizes than the particle size. The particulate material may be used to deliver active agents, such as insecticides and pesticides. The active agents can enter into the hollow core of the particles and be protected from degradation by sunlight. The rough surface of the particles retains the particles on plant leaves or animal hair. Methods for forming the particles are also described. Carbon particles and methods for forming carbon particles are also described.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 31, 2022
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Chengzhong Yu, Meihua Yu, Hongwei Zhang, Yusilawati Ahmad Nor, Hao Song
  • Patent number: 11333728
    Abstract: A pre-polarisation magnet arrangement for generating a pre-polarisation field for use in a low field magnetic resonance imaging process, the pre-polarisation magnet arrangement including a pre-polarisation field array including a plurality of permanent pre-polarisation magnets mounted in a support and provided in a circumferentially spaced arrangement surrounding an field of view, a number of the pre-polarisation magnets being movable between respective first and second positions, wherein in the first position the pre-polarisation magnets are configured as a cylindrical Halbach array to generate a pre-polarisation field in the field of view and in the second position the pre-polarisation magnets are configured to minimize the pre-polarisation field in the field of view.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: May 17, 2022
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Michael Werner Vogel, David Charles Reutens, Andrea Giorni, Ruben Pellicer-Guridi, Viktor Vegh
  • Publication number: 20220143428
    Abstract: The present invention relates to methods of restoring cognitive function in aged individuals that do not exhibit a clinically detectable neurodegenerative disease. In one aspect, the present invention provides a method of improving cognitive function in an aged individual that does not have a neurodegenerative disease characterized by aggregation of a pathological protein, the method comprising or consisting of: applying a clinically safe level of acoustic energy to sites within a region of the brain, thereby saturating or substantially saturating the region with acoustic energy, thereby improving cognitive function in the aged individual.
    Type: Application
    Filed: February 27, 2020
    Publication date: May 12, 2022
    Applicant: THE UNIVERSITY OF QUEENSLAND
    Inventors: Juergen GOETZ, Fabrice TURPIN, Daniel BLACKMORE
  • Publication number: 20220127309
    Abstract: Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.
    Type: Application
    Filed: January 11, 2022
    Publication date: April 28, 2022
    Applicant: The University of Queensland
    Inventors: Keith Joseph CHAPPELL, Daniel WATTERSON, Paul Robert YOUNG
  • Publication number: 20220120745
    Abstract: The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.
    Type: Application
    Filed: August 27, 2021
    Publication date: April 21, 2022
    Applicants: The University of Queensland, Seattle Children's Hospital dba Seattle Children's Research Institute
    Inventors: Yadveer Grewal, Gerard A. Cangelosi, Muhammad J.A. Shiddiky, Matt Trau
  • Patent number: 11279733
    Abstract: There is provided a range of novel compounds. These novel compounds may demonstrate abroad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful when used in conjunction with other pharmaceutically active agents.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: March 22, 2022
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Matthew Cooper, Mark Blaskovich, Alejandra Gallardo-Godoy, Karl Hansford, Alysha Elliott, Craig Muldoon, Bernd Becker
  • Patent number: 11266968
    Abstract: The present invention relates to emulsion-templated silica micro and nano-capsules- and methods for making them. In particular, the template emulsion is stabilized by a biosurfactant that also assists in nucleating the silica shell Mineralizing biosurfactants and stabilized micro- and nano-emulsions useful in forming the emulsion-templated micro- and nano-capsules, and methods for the use of the silica micro- and nano-capsules are also described.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: March 8, 2022
    Assignee: The University of Queensland
    Inventors: Anton Peter Jacob Middelberg, Chun-Xia Zhao, David Wibowo, Brenton Charles Peters
  • Patent number: 11254712
    Abstract: Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: February 22, 2022
    Assignee: The University of Queensland
    Inventors: Keith Joseph Chappell, Daniel Watterson, Paul Robert Young
  • Patent number: 11204404
    Abstract: A pre-polarisation magnet arrangement for generating a pre-polarisation field for use in a low field magnetic resonance imaging process, the pre-polarisation magnet arrangement including a pre-polarisation field array including a plurality of permanent pre-polarisation magnets mounted in a support and provided in a circumferentially spaced arrangement surrounding a field of view, a number of the pre-polarisation magnets being movable between respective first and second positions, wherein in the first position the pre-polarisation magnets are configured as a cylindrical Halbach array to generate a pre-polarisation field in the field of view and in the second position the pre-polarisation magnets are configured to minimize the pre-polarisation field in the field of view.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: December 21, 2021
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Michael Werner Vogel, David Charles Reutens, Andrea Giorni, Ruben Pellicer-Guridi, Viktor Vegh
  • Patent number: 11198632
    Abstract: A method for treating a sludge derived from sewage or wastewater, the method comprising subjecting the sludge to a treatment step at a pH of 8.9 or greater and a free ammonia (FA) content of 100 mg NH3—N/L or greater. The treated sludge may be fed to a bioreactor to produce methane.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: December 14, 2021
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Qilin Wang, Zhiguo Yuan, Haoran Duan, Wei Wei
  • Publication number: 20210347869
    Abstract: The invention relates to tau, to antibodies and related fragments thereof for binding to tau, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, including tauopathies. The invention also relates to compositions comprising tau antibodies for binding to tau and their use in combination with acoustic energy.
    Type: Application
    Filed: October 17, 2018
    Publication date: November 11, 2021
    Applicant: THE UNIVERSITY OF QUEENSLAND
    Inventors: Juergen GOETZ, Rebecca NISBET, Phillip JANOWICZ, Gerhard LEINENGA
  • Patent number: 11136351
    Abstract: The invention relates to alpha conotoxin (?-conotoxin) peptides and methods for their preparation. Also described are pharmaceutical compositions comprising alpha conotoxin (?-conotoxin) peptides and their use in the treatment or prevention of indications 5 associated with nicotinic acetylcholine receptors and/or voltage gated calcium channels.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: October 5, 2021
    Assignee: The University of Queensland
    Inventors: Richard James Clark, James Travis Daniel
  • Patent number: 11130731
    Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: September 28, 2021
    Assignees: The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin, The University Of Queensland
    Inventors: Luke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder
  • Publication number: 20210292397
    Abstract: The present disclosure relates to compositions and methods for inhibiting bacterial aggregation, and in particular, to compositions and methods that inhibit autotransporter-mediated bacterial aggregation or attachment. Described herein are autotransporter binding molecules such as antibodies and antigen binding fragments thereof. The autotransporter binding molecules block self-association between autotransporters and autotransporter-mediated surface attachment.
    Type: Application
    Filed: February 22, 2021
    Publication date: September 23, 2021
    Applicants: La Trobe University, The University of Queensland
    Inventors: Begona Heras, Jason Paxman, Mark Schembri, Alvin Lo
  • Patent number: 11124550
    Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: September 21, 2021
    Assignees: THE UNIVERSITY OF QUEENSLAND, THE JOHNS HOPKINS UNIVERSITY, THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Steven Petrou, Glenn King, Frank Bosmans, David Julius, Jeremiah Osteen, Chuchu Zhang
  • Patent number: 11105802
    Abstract: The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 31, 2021
    Assignees: SEATTLE CHILDREN'S HOSPITAL, The University of Queensland
    Inventors: Yadveer Grewal, Gerard A. Cangelosi, Muhammad J. A. Shiddiky, Matt Trau