Abstract: A gyroscopically stabilised legged robot including: a body; a number of legs coupled to the body and configured for providing legged locomotion of the robot across a surface in use; an orientation sensor for detecting an angular orientation of the body; a control moment gyroscope mounted on the robot, the control moment gyroscope including a rotor that spins around a rotor spin axis in use, and a tilting mechanism for supporting the rotor relative to the robot, the tilting mechanism being configured to rotate the rotor spin axis about two gyroscope rotation axes to thereby generate respective gyroscopic reaction torques; and a gyroscope controller configured to control operation of the tilting mechanism based at least in part on the detected angular orientation of the body, such that gyroscopic reaction torques are generated to at least partially stabilise the angular orientation of the body during the legged locomotion of the robot.

Abstract: The present application relates to a metal organic framework (MOF) glass composite comprising metal halide perovskite, and a method for its preparation.

Abstract: The present invention relates to an optical sensing element for detection of a narcotic, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, wherein emission of the fluorescent sensing compound is quenched in the presence of the narcotic, and wherein the fluorescent sensing compound is non-polymeric and comprises an electron donor moiety, an electron acceptor moiety and a moiety that influences solubility of the compound in a solvent. Sensing devices incorporating the sensing element and methods of detecting narcotics are also described.

Abstract: This invention relates to compositions and uses of genome edited iPSCs and cells derived therefrom. In particular the iPSCs and cells derived therefrom and compositions comprising the same according to the present invention may be used in cell-based therapies for tissue repair or regeneration. The invention relates to the treatment and/or prevention of injury to the myocardium, and/or ischemia reperfusion injury in the myocardium and other vascularized tissues.

Abstract: A method for treating wastewater or sludge comprises the steps of adding the wastewater or sludge to a reactor and mixing the wastewater or sludge with a stream to thereby decrease a ratio of alkalinity to ammonium in the reactor, the reactor containing ammonium oxidising bacteria that oxidise ammonium to produce nitrite and decrease pH.

Abstract: A method is provided for producing renal organoids comprising nephrons, ureteric bud and vasculature and/or progenitors of these. In one embodiment, the methods includes contacting intermediate mesoderm cells with: fibroblast growth factor 9 and/or fibroblast growth factor 20 and/or fibroblast growth factor 2 and optionally, one or more selected from the group consisting of: bone morphogenic protein 7; heparin; a Wnt agonist; retinoic acid; and an RA antagonist under conditions that promote formation of vascularized renal organoids. Another embodiment includes producing mesoderm cells by sequentially contacting pluripotent stem cells with a Wnt agonist and fibroblast growth factor 9 and/or fibroblast growth factor 20 and/or fibroblast growth factor 2, followed by a relatively short re-exposure to the Wnt agonist.

Abstract: Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.

Abstract: A method for the alkaline digestion of soda-lime glass comprising forming a mixture of soda lime glass and a hydroxide solution, the mixture having at least 100 grams of glass per litre of H2O, the hydroxide solution having a concentration of 1M or greater to thereby form an aqueous sodium silicate fraction having a silicate concentration of 50 g/L or greater (calculated as SiO2 equivalent) and a ratio of SiO2:M2O of at least 1, wherein M2O is an alkaline metal oxide, by digesting the glass in the mixture; and separating the aqueous sodium silicate fraction from solids. The solids contain calcium silicate hydrate and undissolved glass. The calcium silicate hydrate can be CSH treated with an acid to thereby dissolve soluble metals from the CSH and separating a liquid phase from a solid phase, the solid phase comprising SiO2 or silica gel.

Abstract: The present invention describes a method of capturing a fluorinated carbon compound located within a liquid, the method comprising contacting the fluorinated carbon compound with a block copolymer having a backbone comprising a hydrophilic block and a fluoropolyether block, wherein the fluorinated carbon compound binds to and is captured by the block copolymer.

Abstract: Provided herein are methods for diagnosing functional gastrointestinal disorders such as functional dyspepsia and irritable bowel syndrome, comprising detecting IgG antibodies in a sample obtained from a subject, wherein the IgG antibodies recognise one or more antigens from Streptococcus salivarius. Also provided are kits for detecting IgG antibodies for use in the diagnosis of functional gastrointestinal disorders, and methods for selecting subjects for treatment for functional gastrointestinal disorders.

Abstract: A method is provided for simultaneously producing both nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting intermediate mesoderm cells with: fibroblast growth factor 9 and/or fibroblast growth factor 20 and optionally, one or more selected from the group consisting of: bone morphogenic protein 7; heparin; a Wnt agonist; retinoic acid; and an RA antagonist. The concentrations of Wnt agonist, retinoic acid and/or RA antagonist may be manipulated to favour the relative production of nephron progenitor cells and ureteric epithelial progenitor cells. The intermediate mesoderm cells are ultimately derived from human pluripotent stem cells via a posterior primitive streak stage. The nephron progenitor cells and ureteric epithelial progenitor cells may have end uses such as for kidney repair and regeneration, bioprinting of kidneys and screening compounds for nephrotoxicity.

Abstract: A fault detection assembly for a PV solar generation assembly comprised of an array of PV modules including a plurality of series PV module strings connected in parallel, the fault detection assembly including: a plurality of current sensors arranged to monitor respective string currents of said strings; a processing arrangement in communication with the current sensors for receiving values of the string currents therefrom; a memory device accessible to the processing arrangement containing instructions for execution by the processing arrangement including instructions for: determining a representative string current for currents of the plurality of strings; deeming one or more strings having currents that are outliers to the representative string current by more than a threshold value to be subject to a fault; and issuing an alarm including an identification of the one or more strings deemed to be subject to the fault.

Abstract: Particulate material comprising rough mesoporous hollow nanoparticles. The rough mesoporous hollow nanoparticles may comprise a mesoporous shell, the external surface of which has projections thereon, the projections having smaller sizes than the particle size. The particulate material may be used to deliver active agents, such as insecticides and pesticides. The active agents can enter into the hollow core of the particles and be protected from degradation by sunlight. The rough surface of the particles retains the particles on plant leaves or animal hair. Methods for forming the particles are also described. Carbon particles and methods for forming carbon particles are also described.

Abstract: In a method for manufacturing a solder joint part, at least one of a first metal base material and a second metal base material is an alloy containing Ni in an amount of more than 0 wt % and less than 44 wt % and Cu in an amount of more than 56 wt %, and solder is a solder alloy containing Ga and inevitable impurities or a solder alloy containing Ga as a main component and having a melting point of 30° C. or lower. The method includes applying the solder to a surface of the first metal base material and placing the second metal base material on the applied solder, and heating the first and second metal base materials to a temperature of 90° C. or lower in a specified atmosphere or in a liquid to generate CuGa2 or (Cu, Ni)Ga2 between the first and second metal base materials, thereby joining the first and second metal material.

Abstract: A method for forming dendritic mesoporous nanoparticles comprising preparing a mixture containing one or more polymer precursors, a silica precursor, and a compound that reacts with silica and reacts with the polymer or oligomer formed from the one or more polymer precursors, and stirring the mixture whereby nanoparticles are formed, and subsequently treating the nanoparticles to form dendritic mesoporous silica nanoparticles or dendritic mesoporous carbon nanoparticles. The silica precursor may comprise tetraethyl orthosilicate (TEOS), the one or more polymer precursors may comprise 3-aminophenol and formaldehyde and the compound may be ethylene diamine (EDA). There is a window of amount of EDA present that will result in asymmetric particles being formed. If a greater amount of EDA is present, symmetrical particles will be formed.

Abstract: Disclosed are processes for preparing hybrid perovskite quantum dots and the resulting hybrid perovskite quantum dots and uses thereof. Such quantum dots are useful as semiconductors in devices such as solar cells and light-emitting diodes.

Abstract: The present disclosure relates to compositions and methods for inhibiting bacterial aggregation, and in particular, to compositions and methods that inhibit autotransporter-mediated bacterial aggregation or attachment. Described herein are autotransporter binding molecules such as antibodies and antigen binding fragments thereof. The autotransporter binding molecules block self-association between autotransporters and autotransporter-mediated surface attachment.

Abstract: This disclosure relates generally to modified SARS-CoV-2 spike polypeptides. More particularly, the present disclosure relates to modified SARS-CoV-2 spike proteins with improved properties, to chimeric polypeptides comprising these modified proteins, and to complexes comprising the chimeric polypeptides. The present disclosure also relates to the use of these modified polypeptides, chimeric polypeptides and complexes in compositions and methods for eliciting an immune response to ACE2-interacting coronaviruses, including SARS-CoV-2, and/or for treating or inhibiting the development of ACE2-interacting coronaviruses infections.

Abstract: This invention provides a method for detecting an analyte in a sample, including a step of contacting said analyte with a nanoparticle to facilitate binding thereto, wherein the nanoparticle comprises: (i) a core; (ii) pores extending radially from said core and being defined by spaces between an array of dendritic spikes radiating outwardly from a surface of the core, wherein the pores have an average pore size of between about 10 nm and about 20 nm; (iii) a binding agent for binding the analyte; and (iv) a detection agent immobilized within said pores; to thereby detect said analyte. This invention also provides kits, compositions and products comprising said nanoparticle.

Abstract: A method for diagnosing one or more diseases of the respiratory tract for a patient including the steps of: acquiring cough sounds from the patient; processing the cough sounds to produce cough sound feature signals representing one or more cough sound features from the cough segments; obtaining one or more disease signatures based on the cough sound feature signals; and classifying the one or more disease signatures to deem the cough segments as indicative of one or more of said diseases; wherein the step of obtaining the one or more disease signatures based on the cough sound feature signals includes applying the cough sound features to each of one or more pre-trained disease signature decision machines, each said decision machine having been pre-trained to classify the cough sound features as corresponding to either a particular disease or to a non-disease state or as corresponding to first particular disease or a second particular disease different from the first particular disease.