Abstract: A method for forming dendritic mesoporous nanoparticles comprising preparing a mixture containing one or more polymer precursors, a silica precursor, and a compound that reacts with silica and reacts with the polymer or oligomer formed from the one or more polymer precursors, and stirring the mixture whereby nanoparticles are formed, and subsequently treating the nanoparticles to form dendritic mesoporous silica nanoparticles or dendritic mesoporous carbon nanoparticles. The silica precursor may comprise tetraethyl orthosilicate (TEOS), the one or more polymer precursors may comprise 3-aminophenol and formaldehyde and the compound may be ethylene diamine (EDA). There is a window of amount of EDA present that will result in asymmetric particles being formed. If a greater amount of EDA is present, symmetrical particles will be formed.

Abstract: Disclosed are processes for preparing hybrid perovskite quantum dots and the resulting hybrid perovskite quantum dots and uses thereof. Such quantum dots are useful as semiconductors in devices such as solar cells and light-emitting diodes.

Abstract: The present disclosure relates to compositions and methods for inhibiting bacterial aggregation, and in particular, to compositions and methods that inhibit autotransporter-mediated bacterial aggregation or attachment. Described herein are autotransporter binding molecules such as antibodies and antigen binding fragments thereof. The autotransporter binding molecules block self-association between autotransporters and autotransporter-mediated surface attachment.

Abstract: This disclosure relates generally to modified SARS-CoV-2 spike polypeptides. More particularly, the present disclosure relates to modified SARS-CoV-2 spike proteins with improved properties, to chimeric polypeptides comprising these modified proteins, and to complexes comprising the chimeric polypeptides. The present disclosure also relates to the use of these modified polypeptides, chimeric polypeptides and complexes in compositions and methods for eliciting an immune response to ACE2-interacting coronaviruses, including SARS-CoV-2, and/or for treating or inhibiting the development of ACE2-interacting coronaviruses infections.

Abstract: This invention provides a method for detecting an analyte in a sample, including a step of contacting said analyte with a nanoparticle to facilitate binding thereto, wherein the nanoparticle comprises: (i) a core; (ii) pores extending radially from said core and being defined by spaces between an array of dendritic spikes radiating outwardly from a surface of the core, wherein the pores have an average pore size of between about 10 nm and about 20 nm; (iii) a binding agent for binding the analyte; and (iv) a detection agent immobilized within said pores; to thereby detect said analyte. This invention also provides kits, compositions and products comprising said nanoparticle.

Abstract: A separator for separating one or more components selected from particulate material, hydrophobic material, non-polar material, microorganisms, or viruses from a mixture of water and the one or more components or from a mixture of a polar liquid and the one or more components, the separator comprising a layer of a metal hydroxide hydrate.

Abstract: A method for diagnosing one or more diseases of the respiratory tract for a patient including the steps of: acquiring cough sounds from the patient; processing the cough sounds to produce cough sound feature signals representing one or more cough sound features from the cough segments; obtaining one or more disease signatures based on the cough sound feature signals; and classifying the one or more disease signatures to deem the cough segments as indicative of one or more of said diseases; wherein the step of obtaining the one or more disease signatures based on the cough sound feature signals includes applying the cough sound features to each of one or more pre-trained disease signature decision machines, each said decision machine having been pre-trained to classify the cough sound features as corresponding to either a particular disease or to a non-disease state or as corresponding to first particular disease or a second particular disease different from the first particular disease.

Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 or R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.

Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

Abstract: The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.

Abstract: A method of automatically diagnosing pneumonia in a patient includes using an input/output interface device to obtain values of two or more diagnostic parameters of the patient from a caregiver for the patient. The method includes using a processor coupled to the input/output interface to apply the two or more diagnostic parameters to an electronic memory storing precompiled pneumonia diagnostic models to identify an optimal diagnostic model for making a diagnosis. The values of the two or more diagnostic signs are applied to the identified optimal diagnostic model to generate a diagnosis output. The input/output interface device is operated in accordance with the diagnosis output to indicate the presence or absence of pneumonia in the patient to the caregiver. The caregiver may use the diagnosis to provide appropriate care to the patient. The pneumonia diagnostic models are derived from investigation of a population of pneumonia positive and non-pneumonia subjects.

Abstract: A method of forming a core-shell polymer nanoparticle encapsulating an active agent is disclosed, including the use of a multi-solvent system in which to dissolve the active agent and a polymer prior to their precipitation using an antisolvent. The preferred use of an organic solvent system comprising two or more organic solvents allows for a high degree of control, as compared with the use of a single solvent, and enables the active agent to be precipitated more or less simultaneously with, or just prior to, the polymer.

Abstract: The present disclosure provides a method and apparatus to perform an electrochemical process by manipulating the charge on an electrode involved in the primary circuit of the electrochemical reaction. The amount of charge on the electrode can be manipulated independent of the bias voltage of the primary circuit and is accomplished by coupling the electrode with various different configurations.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

Abstract: A compact load cell that simultaneously measures normal and shear forces in a load plane offset from a sensor plane by a distance h. The compact load cell comprises at least three force sensing elements (preferably four) arranged in the sensor plane about a point and spaced a distance d from the point. All force sensing elements may be spaced by the same distance or the distance may be different for one or more force sensing elements. Each force sensing element comprises a pressure sensor encased in a force transmission medium. A load plate is in contact with the force transmission medium and a load beam is connected at one end to the load plate above the point of the sensor plane and extends to the load plane. Forces acting in the load plane are transmitted to the sensor plane by the load beam and load plate. The forces are resolved to determine the normal and shear forces acting at the load plane. The compact load cell may be applied to determine forces acting on, for example, an unmanned aerial vehicle.

Abstract: A microwave circulator including an integrated circuit having a number of ports and a respective ring segment coupled to each port to allow microwave frequency signals to be transferred between the port and the respective ring segment. The circulator includes multiple respective ring segments arranged to define multiple parallel circulator rings and at least one superconducting tunnel junction interconnecting each pair of adjacent ring segments and/or a plurality of superconducting tunnel junctions interconnecting each pair of adjacent ring segments to form a circulator ring. The ring segments are configured so that when a bias is applied to the tunnel junctions, signals undergo a phase shift as they traverse the tunnel junctions between ring segments, thereby propagating signals to an adjacent port in a propagation direction.

Abstract: The invention provides an integrated separator system for the preconcentration of a material comprising one or more grizzly bars and one or more electrodes which provide a high voltage pulse (HVP) discharge to the material.

Abstract: Chimeric proteins that comprise one or more amino acid sequences of an insect-specific flavivirus and one or more other immunogenic proteins are provided. The chimeric proteins are suitably capable of forming virus particles. The chimeric protein and/or virus particle may be suitable for delivery to a subject to elicit an immune response to a pathogen and/or for diagnosis or detection of a pathogen. Also provided are nucleic acids and vectors encoding the chimeric proteins, and isolated chimeric insect-specific flaviviruses comprising the chimeric proteins and/or nucleic acids.

Abstract: The present invention relates to antigen binding sites, compositions and uses thereof in the treatment of conditions associated with pathogenic proteins. In one example the condition is Alzheimer's disease.

Abstract: There is provided a range of novel disulfide bond containing compounds. These disulfide bond containing compounds can be used in a variety of applications such as solid phase peptide synthesis, solid phase organic synthesis, formation of dendrimers, formation of macromolecules and formation cyclic peptides; and as a component of a delivery vehicle with a bioactive molecule.