Patents Assigned to University of Queensland
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Patent number: 6017439Abstract: A liquid mixture is efficiently separated using a separating membrane against which the liquid is sprayed, the membrane being intermittently heated to increase separation without subjecting the liquid mixture to high heat. The method is suited to flammable, toxic and temperature sensitive liquid mixtures.Type: GrantFiled: April 27, 1998Date of Patent: January 25, 2000Assignee: The University of QueenslandInventor: Raymond Peter Gannon
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Patent number: 6013262Abstract: This invention relates to a recombinant papilloma virus L1 protein which can elicit an immune response which recognises papilloma virus VLP including L1 protein and can form extracellularly a multimeric structure or VLP wherein the multimeric structure comprises a plurality of recombinant papilloma virus L1 proteins. This invention also includes the use of the recombinant papilloma virus L1 protein to detect the presence of papilloma virus and can form the basis of a vaccine for prophylactic and therapeutic use.Type: GrantFiled: January 16, 1997Date of Patent: January 11, 2000Assignee: The University of QueenslandInventors: Ian Frazer, Jian Zhou
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Patent number: 6004557Abstract: Variants of human papilloma virus (HPV) E6 and E7 able to elicit a humoral or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed, and are useful in treatment or prevention of diseases or conditions involving HPV.Type: GrantFiled: September 22, 1997Date of Patent: December 21, 1999Assignees: CSL Limited, The University of QueenslandInventors: Stirling John Edwards, John Cooper Cox, Elizabeth Ann Webb, Ian Frazer
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Patent number: 6001088Abstract: An iontophoresis method for delivenng an active substance or drug to a target tissue which includes the step of sandwiching the target tissue between a donor electrode and receptor electrode which are each electrically connnected to a power source wherein a current path between the donor electrode and the receptor electrode is maintained at a minimum value to enhance delivery of the active substance to the target tissue.Type: GrantFiled: August 18, 1997Date of Patent: December 14, 1999Assignee: The University of QueenslandInventors: Michael Stephen Roberts, Sheree Elizabeth Cross, Pam Muhtze Lai, Lawrence William Hirst
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Patent number: 5993821Abstract: The invention, in one aspect, is directed to a modified papilloma virus L2 protein which does not bind DNA or which has a substantially impaired ability to bind DNA compared to wild-type papilloma virus L2 protein. The invention is also directed to a method of producing one or more virus-like particles comprising a modified papilloma virus L2 protein according to the invention. The invention also resides in virus-like particles produced from this method.Type: GrantFiled: July 30, 1996Date of Patent: November 30, 1999Assignees: The University of Queensland, CSL LimitedInventors: Ian Frazer, Jian Zhou
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Patent number: 5951871Abstract: A method and apparatus for separating liquid-liquid mixtures such as temperature sensitive mixtures, the method converts the liquid mixture into a spray and sparys the mixture against one side of a membrane. This process improves separation.Type: GrantFiled: January 9, 1997Date of Patent: September 14, 1999Assignee: The University of QueenslandInventor: Raymond Peter Gannon
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Patent number: 5942599Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a .beta.-turn. The stabilized .beta.-turn confers a marked increase in in potency of the analogs; the particular .beta.-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained .beta.-turn being localized in the region of A4-A7.Type: GrantFiled: December 4, 1997Date of Patent: August 24, 1999Assignees: Board of Regents of the University of Nebraska, The University of QueenslandInventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
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Patent number: 5916172Abstract: A diagnostic apparatus for diagnosis of lower back pain (LBP) caused by neuromuscular dysfunction, said diagnostic apparatus comprising:a monitoring means for monitoring an anticipatory muscle signal resulting from one or more electrodes associated with an anticipatory muscle and a prime mover muscle signal resulting from one or more electrodes associated with at least one prime mover muscle associated with a limb; anda processing means for detecting a variation in the time of onset of the anticipatory muscle signal relative to the time of onset of the prime mover muscle signal for providing diagnosis of presence or absence of LBP.Type: GrantFiled: December 30, 1997Date of Patent: June 29, 1999Assignee: The University of QueenslandInventors: Paul William Hodges, Carolyn Anne Richardson
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Patent number: 5916401Abstract: A coating is applied to a substrate using an intermediate membrane. The coating is typically conductive or semiconducting, and the substrate is typically glass. In one form, the coating is applied, in one or more layers, to a flat flexible membrane. The membrane is then placed on the substrate, and the combination is treated under controlled conditions in a heating chamber. The combination is first heated in a neutral atmosphere to cause volatisation of the sacrificial membrane, then successively in oxidising and reducing conditions to cause strong bonding between the coating and the substrate. In another form, a non-sacrificial membrane has a substrate contact surface which is physically and chemically compatible with the substrate and which, when treated either chemically or thermally, forms a bond with the substrate.Type: GrantFiled: October 4, 1996Date of Patent: June 29, 1999Assignee: The University of QueenslandInventor: Raymond P Gannon
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Patent number: 5902943Abstract: The invention relates to an aluminum powder blend and sintered components produced from the aluminum powder blend. The powder is based on the precipitation hardenable 7000 series Al-Zn-Mg-Cu alloys with trace addition of lead or tin. The powder blend comprises 2-12 wt. % zinc, 1-5 wt. % magnesium, 0.1-5.6 wt. % copper, 0.01-0.3 wt. % lead or tin, and the balance aluminum. The invention also provides a composite powder comprising the foregoing powder blend and a reinforcing element or compound.Type: GrantFiled: October 31, 1997Date of Patent: May 11, 1999Assignee: The University of QueenslandInventors: Graham Barry Schaffer, Roger Neil Lumley, Shuhai Huo
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Patent number: 5858081Abstract: Amorphous derivatives of kaolin group minerals characterized by high specific surfaces and/or high cation exchange capacities and a .sup.27 AL MAS NMR spectrum having a dominant peak at about 55 ppm relative to Al(H.sub.2 O).sub.6.sup.3+. Such derivatives are prepared by reacting a kaolin group mineral with a reagent, such as, an alkali metal halide or an ammonium halide which converts the majority of the octahedrally coordinated aluminum in the kaolin group mineral to tetrahedrally coordinated aluminum. Such derivatives show high selectivity in its cation exchange towards the metals: Pb.sup.2+, Cu.sup.2+, Cd.sup.2+, Ni.sup.2+, CO.sup.2+, Cr.sup.3+, Sr.sup.2-, Zn.sup.2+, Nd.sup.3+ and UO.sub.2.sup.+.Type: GrantFiled: January 17, 1996Date of Patent: January 12, 1999Assignee: The University of QueenslandInventors: John Gerard Thompson, Ian Donald Richard Mackinnon, Sasha Koun, Neil Gabbitas
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Patent number: 5840393Abstract: The present invention relates to a printable flexible sheet comprising heat fusible particles and a carrier phase for said particles. The present invention also relates to a method of modifying a heat fusible surface in which the printable flexible sheet is printed with ink, applied to the surface of the substrate. The substrate is then heated such that at least some of the particles and some of the ink fuses to the surface of the substrate.Type: GrantFiled: March 4, 1997Date of Patent: November 24, 1998Assignee: The University of QueenslandInventor: Raymond Peter Gannon
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Patent number: 5818319Abstract: Procedures for designing magnets, including superconducting magnets, shim magnets, and gradient magnets for magnetic resonance systems, are provided. The procedures involve the use of a simulated annealing procedure in which weighted spherical harmonics are included in the procedure's error function. The procedure has resulted in the development of previously unknown magnet designs. In particular, superconducting magnets have been designed which include at least one coil in which the current flow is opposite to that in adjoining coils. Such reversed flow in combination with a relatively large number of coils, e.g., more than 6 coils, have enabled the development of short, yet homogeneous, whole body magnets for use in magnetic resonance imaging (MRI).Type: GrantFiled: December 21, 1995Date of Patent: October 6, 1998Assignee: The University of QueenslandInventors: Stuart Crozier, David M. Doddrell
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Patent number: 5772042Abstract: A method for the flotation processing of mineral ores is disclosed. At least one collector is introduced into the flotation process by atomization. In a preferred aspect of the invention, the collector is provided as a mixture of the thiol and corresponding oxidized thiol (e.g., a dithiol).Type: GrantFiled: December 18, 1995Date of Patent: June 30, 1998Assignee: University of QueenslandInventors: Mark Cleeton Nott, Jonathan James Davies, Emmanuel Manlapig
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Patent number: 5750141Abstract: A vaso-active agent is administered in combination with a therapeutic agent which is useful in treatment of tissue of the body which is located below the stratum corneum or the outermost layer of the epidermis, wherein the vaso-active agent may be administered by a local, topical or transdermal route to a particular site and the therapeutic agent may be administered in a similar manner in combination with the vaso-active agent or may be administered separately, wherein the vaso-active agent and the therapeutic agent for topical and/or transdermal administration may be provided in the form of a composition so as to increase local perfusion and/or concentration of the therapeutic agent at or adjacent an administration site of the vaso-active agent.Type: GrantFiled: December 4, 1995Date of Patent: May 12, 1998Assignee: The University of QueenslandInventors: Michael Stephen Roberts, Sheree Elizabeth Cross, Parminder Singh
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Patent number: 5741215Abstract: A method for stereolithographic construction of models including prostheses and anatomical pathology wherein CT scan data is computed to construct a plurality of two dimensional cross sectional images along one axis and the two dimensional image data is computed to create three dimensional coordinate data sets for the article to be modelled. The three dimensional data sets are then computed to obtain spaced parallel two dimensional image data sets in a second plane of the article and the reconstructed two dimensional image data sets are employed in a stereolithographic modelling apparatus to produce a three dimensional model of the article or part thereof. A prosthetic implant shaped to correct a defect in an anatomical part as well as a method for surgically implanting the implant using the stereolithographic method is also disclosed.Type: GrantFiled: April 25, 1996Date of Patent: April 21, 1998Assignee: The University of QueenslandInventor: Paul Steven D'Urso
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Patent number: 5742463Abstract: A device which may protect circuits or equipment from overload or transients is disclosed. The device includes a unit consisting of a p-channel FET and an n-channel FET connected with their conductive channels in series and the gate of each transistor coupled to the drain terminal of the other.Type: GrantFiled: August 18, 1997Date of Patent: April 21, 1998Assignee: The University of QueenslandInventor: Richard Allen Harris
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Patent number: 5696230Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a .beta.-turn. The stabilized .beta.-turn confers a marked increase in in potency of the analogs; the particular .beta.-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained .beta.-turn being localized in the region of A4-A7.Type: GrantFiled: August 31, 1994Date of Patent: December 9, 1997Assignees: The Board of Regents of the University of Nebraska, The University of QueenslandInventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
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Patent number: 5642048Abstract: The invention concerns a birdcage resonator used as a transmitter and/or receiver coil in an NMR apparatus. The resonator comprises two ring-shaped conductors each of which is interrupted along its outer periphery by capacitors, the ring-shaped conductors being connected together by axial conducting strips. A plurality of axial conducting strips have their ends located between each pair of peripherally neighbouring capacitors. It is preferred when RF energy is coupled in or out between two conducting strips and when the ring-shaped conductors are shielded by shielding rings in the direction towards the sample. The birdcage resonator in accordance with the invention exhibits an improved RF field homogeneity at higher Q compared to conventional birdcage resonators.Type: GrantFiled: February 20, 1996Date of Patent: June 24, 1997Assignee: The University of QueenslandInventors: Stuart Crozier, David Michael Doddrell
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Patent number: 5626399Abstract: An apparatus for cutting and breaking rock includes a cutting disc (13) having an attached wedge (11). Cutting disc (13) can be rotated by shaft (16) to cut a groove into rock. After a pre-determined distance, wedge (11) is forced into the cut groove to cause the rock above the groove to be broken away. Shaft (16) is powered by a drive motor, and can include a kick back mechanism to prevent wedge (11) from being trapped in the cut groove. The entire apparatus can be mounted to the three point linkage of a tractor.Type: GrantFiled: February 8, 1995Date of Patent: May 6, 1997Assignee: The University of QueenslandInventor: Christopher A. Bunker