Patents Assigned to University of Rochester Medical Center
  • Publication number: 20130288976
    Abstract: In one aspect, the invention provides a method of screening a human subject to determine if said subject has a genetic predisposition to develop, or is suffering from Facioscapulohumeral Dystrophy (FSHD), said method comprising: (a) providing a biological sample comprising genomic DNA from the subject; and (b) analyzing the portion of the genomic DNA in the sample corresponding to the distal D4Z4-pLAM region on chromosome 4 and determining the presence or absence of a polymorphism resulting in a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene, wherein a determination of the absence of a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene indicates that the subject does not have a genetic predisposition to develop, and is not suffering from FSHD, and/or wherein a determination of the presence of a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene indicates that the subject has a genetic predisposition to devel
    Type: Application
    Filed: August 18, 2011
    Publication date: October 31, 2013
    Applicants: Fred Hutchinson Cancer Research Center, University of Rochester Medical Center, Leiden University Medical Center
    Inventors: Silvere M. van der Maarel, Stephen J. Tapscott, Rabi Tawil, Richard J.L.F. Lemmers, Linda Geng, Lauren Snider
  • Patent number: 8198323
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: June 12, 2012
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Publication number: 20100197784
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Application
    Filed: April 12, 2010
    Publication date: August 5, 2010
    Applicants: The University of North Carlina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Publication number: 20100160174
    Abstract: Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.
    Type: Application
    Filed: July 27, 2009
    Publication date: June 24, 2010
    Applicant: University of Rochester Medical Center
    Inventors: Harold C. Smith, Mark P. Sowden, Stephen Dewhurst, Baek Kim, Joseph Wedekind
  • Patent number: 7709535
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: May 4, 2010
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Patent number: 7645140
    Abstract: A method for assessing the navigational capacity in human subjects, and its use in diagnosing spatial disorientation in neurodegenerative diseases, such as, for example Alzheimer's disease. The method for assessing the navigational capacity includes conducting a spatial orientation test, recording the results of the test, analyzing the test results and making a determination of the navigational capacity of a human subject. In its most simple sense, navigational capacity includes the capacity not to get lost. The spatial orientation test includes various naturalistic navigation tasks that are each designed to assess specific areas of the navigational capacity of a subject.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: January 12, 2010
    Assignee: University of Rochester Medical Center
    Inventors: Charles J. Duffy, Laura Cushman, Mark Mapstone
  • Publication number: 20090325235
    Abstract: Methods and kits performing reverse transcription and RT-PCR reactions having high fidelity, processivity and DNA polymerase activity are described. The methods involve performance of reverse transcription at an increased temperature with a reverse transcriptase from Simian Immunodeficiency Virus-agm.sab or a variation thereof. The kits of the present invention include a reverse transcriptase from Simian Immunodeficiency Virus-agm.sab or a variation thereof, a DNA polymerase capable of amplifying cDNA under conditions suitable for polymerase chain reaction, and the reagents necessary to carry out both processes.
    Type: Application
    Filed: June 25, 2008
    Publication date: December 31, 2009
    Applicant: University of Rochester Medical Center
    Inventor: Baek KIM
  • Publication number: 20090290766
    Abstract: A method for analyzing the placenta and histology slides of placental tissue comprising: selecting a placental sample to be analyzed; obtaining a digital image of the placental sample; and performing an analysis on the digital image, wherein a mathematical algorithm is applied to the digital image. The results of the analysis are correlated with data on health outcomes in infants, children, or adults and are used to assess future physiological risks to a patient.
    Type: Application
    Filed: May 23, 2008
    Publication date: November 26, 2009
    Applicants: Placental Analytics, LLC., University of Rochester Medical Center
    Inventors: Carolyn M. Salafia, Richard K. Miller
  • Publication number: 20090282496
    Abstract: Disclosed are compositions and methods for treating bladder cancer.
    Type: Application
    Filed: April 3, 2009
    Publication date: November 12, 2009
    Applicant: University of Rochester Medical Center
    Inventor: Chawnshang Chang
  • Patent number: 7595346
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: September 29, 2009
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Patent number: 7546156
    Abstract: A system and method for managing imaging data related to a biological trait, including generating a three-dimensional representation of the external surface of the body a patient; obtaining the imaging data; associating the imaging data with a coordinate location of the three-dimensional representation, to generate an associated imaging data; and managing the associated imaging data using the surface representation. The association includes uniquely associating numerical values (e.g., Cartesian coordinates) to particular surface features. The three-dimensional model includes the ability to adjust the pose of the 3D models made from data taken at different times so that the coordinate systems closely correspond.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: June 9, 2009
    Assignee: University of Rochester Medical Center
    Inventors: Brian C. Madden, Craig C. Miller, Alice P. Pentland
  • Publication number: 20080249400
    Abstract: The invention provides methods for visualizing hepatobiliary structures, or lesions in a liver, intraoperatively by use of fluorescent dyes.
    Type: Application
    Filed: October 5, 2007
    Publication date: October 9, 2008
    Applicant: University of Rochester Medical Center
    Inventors: Dragan Golijanin, Ronald Wood, Jay E. Reeder
  • Publication number: 20080161744
    Abstract: The invention provides methods for pre- and intra-operatively localizing penile sentinel lymph nodes by injection of fluorescent dyes into penile tumors.
    Type: Application
    Filed: September 6, 2007
    Publication date: July 3, 2008
    Applicants: University of Rochester Medical Center, Novadaq Technologies Inc.
    Inventors: Dragan Golijanin, Lukasz Brzozowski, Ronald Wood
  • Publication number: 20080161662
    Abstract: The invention provides methods for visualizing renal tumors and for staging cysts during an operation by use of a fluorescent dye.
    Type: Application
    Filed: August 9, 2007
    Publication date: July 3, 2008
    Applicant: University of Rochester Medical Center
    Inventors: Dragan Golijanin, Edward M. Messing
  • Publication number: 20080161391
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Application
    Filed: February 13, 2008
    Publication date: July 3, 2008
    Applicants: The University of North Carolina, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Publication number: 20080146660
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Application
    Filed: February 13, 2008
    Publication date: June 19, 2008
    Applicants: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Publication number: 20080125663
    Abstract: The invention provides methods for visualizing perfusion or lack thereof in the spermatic cord and testicle, as well as for detecting testicular trauma. A surgical forceps adapted to facilitate such visualization is also provided.
    Type: Application
    Filed: July 19, 2007
    Publication date: May 29, 2008
    Applicant: University of Rochester Medical Center
    Inventor: Drajan Golijanin
  • Publication number: 20080125650
    Abstract: The invention provides methods for visualizing and distinguishing sentinel lymph nodes and involved nodes from other lymph nodes in the vicinity of the bladder in patients undergoing cystectomy or other operations to remove bladder tumors.
    Type: Application
    Filed: July 9, 2007
    Publication date: May 29, 2008
    Applicant: University of Rochester Medical Center
    Inventors: Dragan Golijanin, Edward M. Messing, Jay E. Reeder, Ronald Wood, Aimee Johnson
  • Patent number: 7355081
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: April 8, 2008
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Publication number: 20070173697
    Abstract: A combined flexible and rigid intubating video laryngoscope. The laryngoscope has a handle, and a rigid blade, having a proximal end connectible to the handle and a distal end projecting therefrom. The laryngoscope also has a flexible video endoscope having a distal end connectible near the distal end of the blade, the distal end of the endoscope being movable relative to the distal end of the blade, so as to enable the endoscope to obtain a variable view including a more anterior anatomical view of a patient's vocal cords during direct laryngoscopy.
    Type: Application
    Filed: August 16, 2006
    Publication date: July 26, 2007
    Applicant: University of Rochester Medical Center
    Inventors: Paul Dutcher, Farhan Taghizadeh