Patents Assigned to University of Rochester, Office of Research and Project Administration and Institute of Higher Education
  • Homogeneous human papillomavirus capsomere containing compositions, methods for manufacture, and use thereof as diagnostic, prophylactic or therapeutic agents
    Patent number: 6165471
    Abstract: The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: December 26, 2000
    Assignees: University of Colorado, University Technology Corporation, MedImmune, Inc., University of Rochester, Office of Research and Project Administration and Institute of Higher Education
    Inventors: Robert L. Garcea, JoAnn A. Suzich, Michael P. McCarthy, Robert C. Rose