Patents Assigned to University of Saskatchewan Technologies Inc.
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Patent number: 7732663Abstract: Methods for using cyclin-dependent kinase (CDK) inhibitor genes, or anti-sense constructs complementary to such genes, to modify the growth and development of plant cells and organs are disclosed. Also provided are methods of modifying the development of plant cells and plants by transforming plant cells with nucleic acids encoding cyclin-dependent kinase inhibitor polypeptides, or anti-sense constructs complementary to such nucleic acids, to produce transformed plant cells, and then culturing the plant cells or regenerating a plant under conditions wherein the cyclin-dependent kinase inhibitor, or the anti-sense construct, is expressed. A variety of CDK inhibitor genes, and corresponding anti-sense constructs, are disclosed for use in a variety of plants. The nucleic acid encoding the cyclin-dependent kinase inhibitor may be operably linked to a tissue-specific promoter. Other provided aspects are modified transgenic plants and plant tissues.Type: GrantFiled: July 11, 2006Date of Patent: June 8, 2010Assignees: Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri-Food, University of Saskatchewan Technologies, Inc., The National Research Council of CanadaInventors: Hong Wang, Larry C. Fowke, William L. Crosby
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Publication number: 20070237781Abstract: The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal are provided, such as immunological methods that produce antibodies in the host.Type: ApplicationFiled: December 14, 2006Publication date: October 11, 2007Applicant: University of Saskatchewan Technologies, Inc.Inventors: Jeremy Lee, Palok Aich
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Patent number: 7201895Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids, methods for production thereof, and uses thereof, for a novel ELR-CXC chemokine receptor antagonist.Type: GrantFiled: March 1, 2002Date of Patent: April 10, 2007Assignee: University of Saskatchewan Technologies Inc.Inventors: John R. Gordon, Fang Li
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Patent number: 6984754Abstract: Novel compounds of formula (I) are described wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms; R2=H, CH3 or CH2CH3; R3=H or CH3; R4H or CH3; R5=lower alkyl having from 1 to 5 carbon atoms; n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C?N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R— or S—configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms.Type: GrantFiled: March 25, 1999Date of Patent: January 10, 2006Assignee: University of Saskatchewan Technologies Inc.Inventors: Lillian E. Dyck, Bruce A. Davis, Ya-Dong Liu, David A. Durden, Alan A. Boulton, Brenda Kennedy, Kevin Rogers, I. Alick Paterson
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Publication number: 20050159393Abstract: Novel compounds of the formula I are described: wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms, R2=H, CH3 or CH2CH3 R3=H or CH3 R4=H or CH3 R5=lower alkyl having from 1 to 5 carbon atoms n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C?N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents.Type: ApplicationFiled: March 11, 2005Publication date: July 21, 2005Applicant: University of Saskatchewan Technologies Inc.Inventors: Lillian Dyck, Bruce Davis, Ya-Dong Liu, David Durden, Alan Boulton, I. Paterson, Brenda Kennedy, Kevin Rogers
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Patent number: 6809120Abstract: Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while protecting normal cells from damage. The propargylamine modulators can be used to increase the selectivity and effectiveness of conventional antineoplastic drugs, to reduce the unwanted side-effects of cancer chemotherapy, to improve effectiveness of cancer chemotherapy, to improve treatment of cancers for which treatment is otherwise ineffective, to improve therapy of cancers otherwise unresponsive or poorly responsive due to drug-resistance and/or toxicity limited treatment regimens and to render effective chemotherapy for previously untreatable cancers.Type: GrantFiled: April 10, 2002Date of Patent: October 26, 2004Assignee: University of Saskatchewan Technologies Inc.Inventors: R. C. Warrington, I. Alick Paterson, Alan A. Boulton
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Patent number: 6800308Abstract: The present invention relates to a process for the aqueous extraction, fractionation and enzymatic treatment of oilseed materials to generate valued products with no significant low value by-product or waste streams. In particular, the fractionation scheme generates a protein-fiber feed ingredient principally for use with ruminant animals and a second dephytinized high protein fraction. The dephytinized high protein fraction has value as feed ingredient for a variety of species of animals.Type: GrantFiled: July 23, 2003Date of Patent: October 5, 2004Assignee: University of Saskatchewan Technologies Inc.Inventors: David D. Maenz, Rex W. Newkirk, Henry L. Classen, Robert T. Tyler
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Patent number: 6660320Abstract: An antioxidant extracted from the bearberry plant (Arctostaphylos uva-ursi), particularly for use as a food preservative, and a process of extracting it from the bearberry plant are disclosed. The process includes grinding the leaves of the bearberry, mixing the ground leaves with ethanol, shaking the resulting slurry, filtering the slurry, evaporating the supernatant to dryness and dechlorophyllyzing the resulting precipitate using a silicic acid column with hexane as the mobile phase and recovering the dechlorophyllyzed extract using ethanol as the mobile phase.Type: GrantFiled: June 22, 2000Date of Patent: December 9, 2003Assignee: University of Saskatchewan Technologies Inc.Inventors: Ronald Bruce Pegg, Branka Barl, Ryszard Amarowicz
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Patent number: 6554811Abstract: An internal artificial vagina for collecting animal semen including a stiff support frame comprising a straight bar portion having at one end thereof a generally circular ring portion substantially perpendicular to the axis of the bar portion and an attachment means at the other end of the bar portion. An elastomeric tube open at both ends is adapted to slide within the frame ring portion with an end portion of the elastomeric tube stretched and pulled outwardly around the frame ring portion whereby the ring portion is retained within the folded portion of the elastomeric tube. The other end portion of the elastomeric tube is fixed to the attachment means of the frame. A replaceable semen collection bag is also provided in the form of an elongated generally cylindrical thin, flexible plastic member having a closed end and an open end.Type: GrantFiled: September 5, 2001Date of Patent: April 29, 2003Assignee: University of Saskatchewan Technologies Inc.Inventor: Albert D. Barth
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Publication number: 20030013672Abstract: The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal are provided, such as immunological methods that produce antibodies in the host.Type: ApplicationFiled: January 31, 2002Publication date: January 16, 2003Applicant: University of Saskatchewan Technologies, Inc.Inventors: Jeremy S. Lee, Palok Aich
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Patent number: 6432641Abstract: The invention provides conductive polymers comprising metal-containing nucleic acid duplexes electrically coupled to an electron source. Methods for making conductive metal-containing nucleic acid duplexes are provided, comprising subjecting a nucleic acid duplex to basic conditions in the presence of a divalent metal cation. Methods of using conductive metal-containing nucleic acid duplexes are provided, including methods of genomic analysis, methods of molecular screening and immunological methods that produce antibodies to such molecules.Type: GrantFiled: December 16, 1998Date of Patent: August 13, 2002Assignee: University of Saskatchewan Technologies Inc.Inventors: Jeremy S. Lee, Palok Aich
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Patent number: 6413999Abstract: A method of promoting functional recovery and reducing oxidative stress and inflammation following an acute physical insult to the central nervous system, comprising administering to a mammalian patient which has suffered an acute physical insult to the central nervous system an initial dose of L-2-oxothiazolidine-4-carboxylate (“OTC”) or a variant thereof is disclosed. This method preferably further includes the step of administering a number of subsequent doses of OTC or a variant thereof as subsequent time periods. Also provided is a use of OTC or a variant thereof in the preparation of a medicament useful in reducing inflammation in the central nervous system and promoting the functional recovery of a mammalian patient which has suffered an acute physical insult to the central nervous system, such as neurotrauma, stroke or aneurysm.Type: GrantFiled: August 17, 2000Date of Patent: July 2, 2002Assignee: University of Saskatchewan Technologies Inc.Inventors: Bernhard Juurlink, Robert Griebel, Huse Kamencic, Phyllis Paterson
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Patent number: 6017933Abstract: Mannich bases of conjugated styryl ketones have been developed which are effective as cytotoxicity and anticancer agents, and which also have antifungal activity. Preferred compounds are those of the formula ##STR1## where R.sub.1 is Cl, CH.sub.3 or OCH.sub.3 and R.sub.2 is H or Cl. A compound of particular interest is (3-[3-(4-chlorophenyl)-2-propenoyl]-4-[2-(4-chlorophenyl)vinylene]-1-ethyl -4-piperidinol hydrochloride.Type: GrantFiled: January 28, 1999Date of Patent: January 25, 2000Assignees: University of Saskatchewan Technologies Inc., Wayne State UniversityInventors: Jonathan R. Dimmock, Elias K. Manavathu
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Patent number: RE38425Abstract: A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system: wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9 alkyl, C3-9cycloalkyl, cyano, C1-9alkoxy or C6-10aryloxy group; R5 represents a hydrogen atom or a C1-9alkyl, C3-9cycloalkyl or C6-10aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.Type: GrantFiled: April 20, 2000Date of Patent: February 10, 2004Assignee: University of Saskatchewan Technologies, Inc.Inventors: Jonathan Richard Dimmock, Ramanan Narayan Puthucode