Abstract: There is provided novel anticancer and antibacterial compounds, pharmaceutically acceptable salts thereof, and processes for their preparation. The compounds have anticancer activity, which results in the reduction of tumour cell proliferation, enhances cancers cells apoptosis and regulation of iron signalling. The compounds are also particularly active against various Gram-negative and Gram-positive multidrug-resistant bacteria, such as extended-spectrum beta-lactamase (ESBL) producing and colistin-resistant Escherichia coli, carbapenem-resistant E. coli, carbapenem-resistant Acinetobacter baumannii, and methicillin-resistant Staphylococcus aureus (MRSA) including those with reduced susceptibility to many control antibiotics.

Abstract: Systems and methods for producing liposomes, including control liposomes and immunoliposomes targeting breast cancer are provided. Systems and methods for treating breast cancer, using targeted immunoliposomes produced according to various methods are also disclosed herein. For example, trastuzumab-conjugated immunoliposomes may be used to deliver chemotherapeutic agents to breast cancer tissues for the treatment of breast cancer. Systems and methods for actuating liposomes using ultrasound are also disclosed, such as systems and methods for actuating trastuzumab-conjugated liposomes accumulated in breast cancer tissues for the treatment of breast cancer.

Abstract: Novel heterocyclic fused systems are disclosed herein which possess numerous biological activities, including but not limited to antibacterial activity, and usefulness to the treatment of many disease states, such as pathogenic infections. In particular, new imidazoles are disclosed along with related processes of preparation and methods of use as antibacterial agents. The disclosed compounds were found to be active against several Gram-positive bacteria, including Enterococcus faecalis and Bacillus subtilis, and were also found to be active against several species of multi-drug resistant Staphylococcus, such as S. aureus, S. saprophyticus, S. haemolyticus, and S. epidermidis.

Abstract: A system including a float ball, a pole, a sleeve, an indicator disk, and a dynamo circuit provides information regarding the water level in a tank, and whether fluid is flowing into the tank. The pole slides within the sleeve, through a slab above the tank. A first end of the pole is supported by the float ball, which floats within the tank, while the second end of the pole is located above the slab and supports the indicator disk. A user can detect the water level in the tank based on the height of the indicator disk. A user can also detect whether water is flowing into the tank. The dynamo circuit activates an LED located on the indicator disk when water is flowing into the tank.

Abstract: This invention provides a novel technique separating two mixed signals. The method is particularly useful for fetal electrocardiogram estimation. A maternal electrocardiogram signal recorded at the thorax area is nonlinearly mapped onto an electrocardiogram signal recorded at the abdomen using polynomial networks. The fetal electrocardiogram component is then estimated by subtracting the nonlinearly mapped maternal electrocardiogram signal from the abdominal electrocardiogram signal.