Abstract: This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.
Type:
Grant
Filed:
February 20, 2003
Date of Patent:
March 1, 2011
Assignees:
Medtronic, Inc., University of South Florida Research Foundation, Inc.
Inventors:
Rudy A. Mazzocchi, Matthew S. Solar, Thomas B. Freeman
Abstract: A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
Type:
Grant
Filed:
June 21, 2002
Date of Patent:
May 27, 2003
Assignees:
Genetronics, Inc., The University of South Florida Research Foundation,
Inc.
Inventors:
S. B. Dev, Gunter A. Hofmann, Richard A. Gilbert, Richard Heller, Mark J. Jaroszeski