Patents Assigned to University of Southampton Highfield
  • FK 228 derivates as HDAC inhibitors
    Patent number: 7977304
    Abstract: Compounds which are FK228 analogues of the general formula (I) or (I?), isosteres thereof and pharmaceutically acceptable salts thereof are found to inhibit HDAC wherein R1, R2, R3 and R4 are the same or different and represent an amino acid side chain moiety and each R6 is the same or different and represents hydrogen or C1-C4 alkyl.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: July 12, 2011
    Assignee: University of Southampton Highfield
    Inventors: Arasu Ganesan, Graham Keith Packham, Alexander Yurek-George, Alexander Richard Liam Cecil
  • Anti-virus therapy for respiratory diseases
    Publication number: 20070134763
    Abstract: The present invention provides the use of IFN-?, an agent that increases the expression of IFN-?, or a polynucleotide which is capable of expressing IFN-? or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-? for the same purpose.
    Type: Application
    Filed: September 8, 2006
    Publication date: June 14, 2007
    Applicants: University of Southampton Highfield, Imperial Innovations Limited
    Inventors: Donna Davies, Peter Wark, Stephen Holgate, Sebastian Johnston