Patents Assigned to University of Souththern California
  • METHODS FOR PREPARING HIGH THROUGHPUT PEPTIDOMIMETICS, ORALLY BIOAVAILABLE DRUGS AND COMPOSITIONS CONTAINING SAME
    Publication number: 20150050211
    Abstract: Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability.
    Type: Application
    Filed: August 31, 2012
    Publication date: February 19, 2015
    Applicant: University of Souththern California
    Inventors: Stephen V. Fiacco, Terry T. Takahashi, Richard W. Roberts