Abstract: The disclosure provides a method of producing a pharmaceutical composition. The method comprises (a) dissolving an active pharmaceutical ingredient (API) in a liquid vehicle to form a liquid medicament; (b) contacting the liquid medicament with a pharmaceutical carrier; (c) contacting the composition comprising the liquid medicament and pharmaceutical carrier with a pharmaceutical coating material to form a liqui-mass composition; and (d) pelletising the liqui-mass composition to form the pharmaceutical composition.

Abstract: The present invention relates to compounds of formula (I) and compositions comprising the same. The compounds and compositions may be used treat, prevent or ameliorate diseases treatable by inhibition of the Lemur tyrosine kinase 3 (LMTK3), such as cancer.

Abstract: A device for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output. The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

Abstract: A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.

Abstract: The present invention relates to a hypoxia-inducible factor (HIF) activator, or a pharmaceutically acceptable salt or solvate thereof, for use in promoting tissue repair. The HIF activator, or the pharmaceutically acceptable salt or solvate thereof, is for use with a prototypical tissue-protective cytokine, or a pharmaceutically acceptable salt or solvate thereof, which is administered exogenously to the body being treated.

Abstract: An instrument (20) determines the attitude of a spacecraft (3) on which it is mounted, by interacting incident light (11) from the Sun with one or more light conditioning elements (12) and thereby forming a diffraction pattern at a photo-sensitive detector (13). The intensity distribution of light on the detector (13) is dependent on the angle of incidence of the light (11). An on-board computer (16) determines a direction vector to the Sun based on the light diffraction pattern detected by the detector (13).

Abstract: A nuclear microbattery is disclosed comprising: a radioactive material that emits photons or particles; and at least one diode comprising a semiconductor material arranged to receive and absorb photons or particles and generate electrical charge-carriers in response thereto, wherein said semiconductor material is a crystalline lattice structure comprising Aluminium, Indium and Phosphorus.

Abstract: A photodiode for use in detecting X-rays and/or gamma rays is disclosed. The photodiode comprises InGaP arranged and configured to absorb X-rays and/or gamma-rays incident on the photodiode and generate charge-carriers in response thereto. The detector may be provided in an X-ray or gamma-ray photon counting spectrometer.

Abstract: A device for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output. The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

Abstract: A system (100) for generating an olfactory experience comprises a user interface (120) that allows a user to provide a set of input parameters that define a desired olfactory experience. The system (100) further comprises a set of processing modules (104) that convert the set of input parameters into a set of scent delivery instructions for one or more scent delivery devices (106), (108) to follow. The system *100) can allow a variety of desired olfactory experiences to be indicated by a user and then allow those desired olfactory experiences (or suitable approximations or equivalents thereof) to be provided by a variety of scent delivery devices that may be available to the system (100).

Abstract: A device (20) for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output (30). The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

Abstract: The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.

Abstract: The invention relates to lubricant analysis, and to apparatus and methods for carrying out real-time in situ lubricant analysis. The invention extends to apparatus and methods which can measure tribological wear in machinery and, in particular, to the in situ measurement of the elemental composition of lubricant and/or debris caught in a filter within a lubricant-wetted machine.

Abstract: The invention provides a target object detection system, comprising a plurality of sensing nodes (10) for positioning at respective detection locations with respect to a detection area (12) that is situated within a field generated by an ambient AC source of excitation. Each sensing node has at least one electric potential sensor (22, 42) designed to detect perturbations in said field caused by a target object (14), said one sensor including an electrode (20, 40) responsive to the AC excitation field for generating detection signals, an amplifier (28) connected to the electrode for receiving and amplifying the detection signals to produce AC measurement signals as output, and at least one feedback circuit (30, 36) from an output of the amplifier to an input thereof for enhancing the input impedance of the amplifier.

Abstract: The invention provides a charged particle sensor (10) for detecting and measuring ionic current generated by charged particles resulting from ionization processes, comprising: a housing (16), a detection electrode (14) enclosed within the housing for collecting the charged particles, and an electrometer (12) having an input connected to the detection electrode for receiving a DC input signal therefrom and an output (18) for supplying a DC measurement signal as output. The housing comprises an electrostatic screen (16) for screening the detection electrode from external electric fields, whereby to reduce the sensitivity of the detection electrode to such fields.

Abstract: The present invention relates to chiral ligands deriving from ?- and ?-amino acids, and from metal complexes formed from the same. The ligands are useful with catalytic gold complexes, particularly Au(I) complexes.

Abstract: An ion trap comprising: a first array of magnetic elements arranged to generate a first magnetic field with a degree of homogeneity; and an array of electrodes arranged to generate an electrostatic field including a turning point in electrical potential at a location where the magnetic field has a substantially maximum degree of homogeneity; wherein the array of electrodes is planar and parallel to the direction of the magnetic field at the location; and wherein a primary first magnetic element is arranged to generate a first component of the first magnetic field and other first magnetic elements are arranged to generate compensating components of the first magnetic field that reduce the gradient, the curvature and higher order derivatives of the first component of the first magnetic field at the location where the first magnetic field has the substantially maximum degree of homogeneity.

Abstract: An electrodynamic sensor comprises a high input impedance electrometer adapted to measure small electrical potentials originating from an object under test and having a pair of input probes, characterized in that at least one of said pair of input probes has no direct electrical contact with said object, wherein the circuit arrangement of said electrometer comprises an electrode (1) connected to an amplifier (9), which includes a combination of ancillary circuits cumulatively to increase the sensitivity of said electrometer to said small electrical potentials while not perturbing the electrical field associated therewith.

Abstract: The present invention provides a sensor system and a corresponding sensing method employing the sensor system. The sensor system comprises a sensor (12) having an input (20) and an output (22), a feedback path (16) from the output to the input, and a filter (14; 92) in the feedback path. The filter comprises a narrow band filter, which is tuned or tunable to a respective one of signals that are wanted signals and signals that represent interference signals. The sensor and the filter are arranged so as to alter the relative amplitudes of the wanted signals and the interference signals in order to increase the relative amplitude of the wanted signals and reduce the relative amplitude of the interference signals.

Abstract: The invention provides a method and apparatus for the detection of charge density distribution at the surface of a material sample. The apparatus comprises an electric potential sensor for measuring surface charge on a material sample, wherein the electrical potential sensor includes a probe for capacitively coupling the electric potential sensor to the surface of the material sample, an amplifier for generating a measurement output, the probe being connected to an input of the amplifier and the measurement output being supplied at an output of the amplifier, and a feedback arrangement driven from the output of the amplifier for enhancing the input impedance of the amplifier.