Abstract: The invention relates to genes which may be utilized to induce resistance to soybean cyst nematode (SCN). More specifically the present disclosure provides genes that, when inactivated or overexpressed in a plant, particularly, a soybean plant, can confer upon the plant resistance to SCN. Methods of using these genes to obtain plants, particularly, soybean plants, that are resistant to SCN are also provided.

Abstract: Provided herein are modified immunoglobulins comprising an amyloid reactive peptide joined to an antibody, as well as humanized antibodies that bind to human amyloid fibrils and antibody-peptide fusion proteins. Also provided herein are methods of treating amyloid-based diseases by administering a modified immunoglobulin, humanized antibody, or antibody-peptide fusion protein.

Abstract: A self-healing adhesive composition comprising a homogeneous mixture of: (i) a self-healing polymer containing hydrogen bonding groups or long-chain alkyl groups, wherein said hydrogen bonding groups comprise hydrogen bond donating groups and hydrogen bond accepting groups, and wherein said long-chain alkyl groups contain at least four carbon atoms; and (ii) an extrudable adhesive polymer base having a curable property and no self-healable property; wherein component (i) is present in the self-healing adhesive composition in an amount of at least 10 wt % and up to 70 wt % of the total of components (i) and (ii). Also described herein is a method of sealing a space (e.g., crack, gap, or pores) in a substrate material by at least partially filling the space with the self-healing adhesive composition described above and permitting the self-healing adhesive composition to harden over time without applying an external stimulus to induce hardening.

Abstract: An improved method of preparing a carbon fiber-reinforced thermoplastic nonwoven web using recycled carbon fibers employs resonant acoustic mixing to combine the recycled carbon fibers with the thermoplastic fibers, followed by carding of the fiber mixture to form the carbon-fiber reinforced nonwoven web. The method provides a low-cost way to make carbon-fiber reinforced nonwoven webs that have sufficient mechanical properties to enable widespread use in the automotive industry and other high-volume industries.

Abstract: Provided herein are antibody-peptide fusion proteins comprising an amyloid-reactive peptide linked to an antibody. Also provided herein are methods of treating amyloid-based diseases by administering an antibody-peptide fusion protein.

Abstract: A multivalent immunogenic composition is provided, including one or more recombinant proteins selected from the group consisting of a recombinant attenuated Staphylococcus pseudintermedius Protein A (SEQ ID NO:2), a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin S (SEQ ID NO:4), a recombinant attenuated Staphylococcus pseudintermedius Nucleotidase adenosine synthase protein (AdsA) (SEQ ID NO:6), a recombinant attenuated Staphylococcus pseudintermedius coagulase (SEQ ID NO:8), a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin F (SEQ ID NO:10), and a recombinant attenuated Staphylococcus pseudintermedius exotoxin 15 (SEQ ID NO:12). Synthetic genes expressing the attenuated recombinant proteins and optimized for expression in E. coli are provided. Vaccines and therapeutic compositions comprising the one or more recombinant proteins are provided.

Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Apparatus and systems disclosed herein are designed to be used to study various forces acting on an athletic field or an athletic surface caused by the interaction between a shoe and the turf or athletic surface during a simulated impact. Various surfaces can be tested and analyzed, including assessing deceleration, acceleration and cutting traction potential on the surfaces. The disclosed apparatuses and systems allow for the testing of a wide variety of footwear, at any desired impact angle, and at various simulated forces. Methods, systems, and computer readable media for generating graphical representations associated with surface performance test information are also disclosed herein.

Abstract: The disclosure relates to methods for characterizing and/or treating a subject having cancer, said methods comprising performing an assay to identify the nucleotides present at each of a set of single-nucleotide polymorphism (SNP) locations within the cytarabine (ara-C) pathway, assigning a genotype score for the identified nucleotides of each SNP, and characterizing the subject having cancer based on the summation of the assigned genotype scores. In some embodiments, treatment is administered based upon the characterization of the subject, according to the methods described herein.

Abstract: This invention relates to the treatment of breast cancer in a subject, for example a female subject.

Abstract: The present invention relates to solid forms of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and processes for producing the same.

Abstract: of treating Gram-negative bacteria that also exhibit resistance to the anti-bacterial compound colistin (MIC?50 mg/mL) except for Burkholderia, Proteus, and Serratia that comprises contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of Formula I, below, dissolved or dispersed therein at a concentration of about 0.01 to about 15 mg/mL and irradiating those contacted bacteria with light of the wavelength about 500 nm to about 600 nm for a time period of about 1 to about 10 minutes to provide a light dose of about 16 to about 160 J/cm2, treat and kill the irradiated bacteria wherein X, R1, R2 and M+ are defined within.

Abstract: The present disclosure related to compounds of Formula (I): stereoisomers thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, including to treat cancer in a subject.

Abstract: A method of additive manufacturing is described wherein powder material is spread in a layer, contacted with a binding polymer and cured with light. Also described is a system for preparing additive manufactured objects such as molds, tools and composites.

Abstract: A method and system for detection of retinal hemorrhages using head computed tomography incorporating deep learning includes obtaining a patient head computed tomography image, segmenting globes using a deep-learning model, rotating the scans using the angle between globes, cropping and masking the globes, and stacking the globes to form 3D individual images that are analyzed for presence of retinal hemorrhage.

Abstract: A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals.

Abstract: Machine learning approach can combine mass spectral imaging (MSI) techniques, one with low spatial resolution but intact molecular spectra and the other with nanometer spatial resolution but fragmented molecular signatures, to predict molecular MSI spectra with submicron spatial resolution. The machine learning approach can perform transformations on the spectral image data of the two MSI techniques to reduce dimensionality, and using a correlation technique, find relationships between the transformed spectral image data. The determined relationships can be used to generate MSI spectra of desired resolution.

Abstract: The present invention relates to solid forms of (S)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same.

Abstract: Filter media comprising cellulose fibers and fibrillated thermoplastic fibers, such as fibrillated polyolefins are described. The filter media can be provided in the form of non-woven fiber mats (e.g., wet-laid non-woven fiber mats) that can be integrated into air filtration devices to enhance their biodegradability. The non-woven fiber mats can be prepared as electrets. Composites comprising multiple layers of the same or different filter media can be prepared. Composites having minimum efficiency reporting value (MERV) ratings of at least 12 or at least 13 are described.

Abstract: Modified maleic acid copolymers have an esterified styrene maleic acid or diisobutylene maleic acid. The copolymers have 1% to 90% total esterification of the maleic acid (MA), thereby having an ester of Y1 and/or Y2 of the general formula —OR1. R1 is a moiety present in enough units of the copolymer in one or both of Y1 and Y2 to provide a preselected percent of total esterification, and if either or both of Y1 and Y2 are not esterified, it is a hydrogen or a carboxylate unit with a counterion X+. R1 comprises (i) a linear alkane chain, (ii) a linear chain alkoxy alkane of the formula —(CH2)qO(CH2)rCH3, (iii) an alkane containing or terminating with a cyclic carbon chain, (iv) an alkoxy alkane containing or terminating with a cyclic carbon chain, (v) a chain containing a repeating sequence of (CH2CH2O)t terminating with —OR2, or a mixture of (i) to (v).