Patents Assigned to University of Tennessee Research Company
  • Cationic amphiphiles of cholesterol
    Publication number: 20030012813
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Application
    Filed: August 22, 2002
    Publication date: January 16, 2003
    Applicant: University of Tennessee Research Company
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Cationic amphiphiles of cholesterol
    Publication number: 20020114828
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Application
    Filed: November 20, 2001
    Publication date: August 22, 2002
    Applicant: University of Tennessee Research Company
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega