Patents Assigned to University of Tennessee Research Corporation
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Patent number: 4947640Abstract: A photon ignition system for igniting the air/fuel spray within a combustion chamber of a gas turbine engine is comprised of a photon source 20, a photon transmission means 22 and a focussing means 24. The source 20 has an output wavelength characteristic suitable for being absorbed by the hydrocarbon fuel droplets within the fuel spray. In accordance with one embodiment of the invention the source 20 comprises an ultraviolet flashlamp having spectral characteristics which are selected to be strongly absorbed by hydrocarbon fuel. In another embodiment of the invention the source 20 comprises a laser, such an excimer laser, having an output pulse with wavelengths within the strong absorption range of hydrocarbon fuel. The photon output of the source 20 is focussed within an optimum region of the fuel spray for igniting one or more droplets therein due to the absorption and subsequent heating of the droplets of the focussed photon output.Type: GrantFiled: February 28, 1989Date of Patent: August 14, 1990Assignee: University of Tennessee Research CorporationInventors: Jimmy D. Few, James W. L. Lewis
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Patent number: 4947323Abstract: A method and apparatus are disclosed for measuring spatial dimensions of an object. The object is positioned between a radiation source and a radiation sensitive surface, such as between an X-ray unit and an X-ray film. The distance between the object and the X-ray unit is small relative to the distance between the object and the film. An the image of the object is produced on the film when radiation is emitted from the X-ray unit, and by virtue of the spacing of the object between the source and the film, the object is magnified, but is severely blurred. The image is then digitized and restored using two-dimensional deconvolution techniques to remove the blur, resulting in an enlarged, clear image. Edge-detection algorithms are then used to enable measurement of the spatial dimension. This permits accurate measurement of small internal dimensions of the object such as voids or cracks in bonded or welded components.Type: GrantFiled: November 8, 1988Date of Patent: August 7, 1990Assignee: University of Tennessee Research CorporationInventor: Lewis M. Smith
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Patent number: 4942162Abstract: A method is provided for treating psoriasis and seborrheic dermatitis in humans by topical application of an effective, lesion reducing amount of ketoconazole to affected areas.Type: GrantFiled: January 27, 1989Date of Patent: July 17, 1990Assignee: University of Tennessee Research CorporationInventors: E. William Rosenberg, Patricia W. Belew-Noah
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Patent number: 4940581Abstract: A method for preserving blood platelets by freezing the platelets in contact with a cryoprotectant solution containing a sufficient quantity of prostacyclin for the substantially complete inhibition of platelet function and having a pH which promotes the preservation of the platelets and reconstituting the platelets for infusion.Type: GrantFiled: August 15, 1988Date of Patent: July 10, 1990Assignee: The University of Tennessee Research CorporationInventors: James M. Mason, David D. Pifer
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Patent number: 4931192Abstract: A method for disposing of non-polar organic wastes including the steps of dissolving the organic waste in an organic solvent which is not environmentally objectionable, in combination with a suitable surfactant, mixing the resultant solution with a quantity of water to develop an emulsion in which the organic element is effectively dispersed in the water and thereafter mixing the emulsion with cement which, when allowed to solidify, encapsulates the organic waste within the solid cementitious mass. This solid mass is suitable for disposal in a landfill or the like. This invention is useful in safely disposing of environmentally hazardous organic wastes.Type: GrantFiled: March 22, 1989Date of Patent: June 5, 1990Assignee: The University of Tennessee Research CorporationInventors: J. Stansill Covington, Michael A. McBride, Michael E. Hayes
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Patent number: 4928957Abstract: An exercise apparatus for bending the user's legs by the exercise of muscles in the user's upper body includes a stationary frame, a seat mounted upon the frame for forward and rearward movement relative thereto and hinged leg support sections which fold and unfold in synchronism with the forward and rearward movement of the seat. To use the apparatus, a user sits upon the seat with his legs draped over the hinged leg supports and he pushes and pulls upon the stationary frame to effect the forward and rearward movement of the seat relative to the frame. As the leg support sections are folded and unfolded in response to the forward and rearward movement of the seat, the user's legs are bent at the waist and knees. A hydraulic cylinder is interposed between the frame and seat providing an adjustable resistance to the forward and rearward movement of the seat.Type: GrantFiled: December 2, 1988Date of Patent: May 29, 1990Assignee: University of Tennessee Research CorporationInventors: Joel P. Lanier, Tamuel A. Hall, Kent R. Moore
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Patent number: 4919930Abstract: Synthetic peptide segments of protein Pep M5 containing epitopes capable of evoking type specific opsonic antibodies against streptococci when covalently linked to a protein carrier.Type: GrantFiled: May 1, 1986Date of Patent: April 24, 1990Assignee: University of Tennessee Research CorporationInventors: Edwin H. Beachey, James B. Dale
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Patent number: 4917874Abstract: Alkali metal sulfates are converted to a sulfur-free form by dissolving the alkali metal sulfate in water to produce an aqueous solution containing alkali metal ions and sulfate ions at a pH below about 8, and then passing the solution through a weak base, anion exchange resin having bicarbonate ions associated therewith that exchange with the sulfate ions so that the sulfate ions become associated with the resin and the bicarbonate ions become associated with the alkali metal ions in the solution. The resin can be regenerated to the bicarbonate form by treatment with an ammonium hydroxide solution followed by contact with carbon dioxide and the regeneration by-products are commercially useful.Type: GrantFiled: June 24, 1988Date of Patent: April 17, 1990Assignee: The University of Tennessee Research CorporationInventors: Atul C. Sheth, William A. Butler
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Patent number: 4906434Abstract: Apparatus and methods for compressing a mass utilizing a plurality of interfitting anvils mounted for movement relative to one another along co-planar paths and include faces which, when the anvils are operatively moved relative to one another, exert compression on a mass positioned between the faces in at least two directions in a plane simultaneously. The faces of the apparatus can be so shaped that the cross section of the mass being compressed is urged toward a shape other than that of a regular polygon. Methods of the invention include the consolidation of a mass of compactable material enclosed within a hollow tube having deformable walls, the extraction of juice or oil from fruit or seeds and the internal fracturing of solids so as to swell materials such as solid rocket propellants.Type: GrantFiled: September 13, 1988Date of Patent: March 6, 1990Assignee: University of Tennessee Research CorporationInventor: Kenneth H. G. Ashbee
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Patent number: 4879316Abstract: Interpenetrating polymer network ion exchange membranes include a microporous polymeric support film interpenetrated by an ion exchange polymer and are produced by absorbing and polymerizing monomers within the support film. The ion exchange polymer provides ion exchange ligands at the surface of and throughout the support film which have sufficient ligand mobility to extract and transport ions across the membrane.Type: GrantFiled: February 26, 1987Date of Patent: November 7, 1989Assignee: The University of Tennessee Research CorporationInventors: Spiro D. Alexandratos, Pier R. Danesi, E. Philip Horwitz
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Patent number: 4855112Abstract: An apparatus for aerosol direct fluorination is disclosed in which a material to be fluorinated is formed into an aerosol prior to fluorination by introducing a vapor stream of the material to be fluorinated centrally into converging flows of carrier particles suspended in a gas and condensing the vapor onto the particles. Fluorine is contacted with the aerosol in an elongated fluorination reactor having microporous walls providing a substantially continuous influx of fluorine-containing gas which creates an increasing fluorine concentration gradient as the aerosol moves through the reactor and provides a barrier to prevent contact of the aerosol with the microporous walls. A photochemical stage includes an elliptical reflector with a light source of one focus and a flow of aerosol and fluorine at the others.Type: GrantFiled: August 21, 1987Date of Patent: August 8, 1989Assignee: The University of Tennessee Research CorporationInventor: James L. Adcock
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Patent number: 4851554Abstract: The disclosure relates to compounds of the formula ##STR1## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, wherein R.sub.5 is a lower alkyl group, wherein R.sub.6 is either hydrogen or methyl, wherein Am is selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazino, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y.sub.1 and Y.sub.2 are identical and are hydrogen, a halogen, methyl or ethyl048505325 and n is an integer in the range of 1-5.Type: GrantFiled: September 30, 1987Date of Patent: July 25, 1989Assignee: University of Tennessee Research CorporationInventors: Thomas P. Kennedy, George W. Kabalka
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Patent number: 4839111Abstract: Preferred solid core liposomes were prepared through four major steps:(1) Preparation of prevesicles with encapsulated solid cores of agarose-gelatin by emulsification of agarose-gelatin sol in organic solvent containing emulsifiers followed by cooling;(2) Extraction of lipophilic components from prevesicles to obtain microspherules of agarose-gelatin;(3) In an optional step, colloidal gold particles were introduced into the microspherules, which were then coated with a protein or peptide molecule layer;(4) Encapsulation of the microspherules was conducted using a modified organic solvent spherule evaporation method for the formation of the liposomes.Electron micrographs indicate that if liposomes were prepared by using a lipid mixture containing dioleoyl phosphatidyl choline, cholesterol, dioleoylphosphatidylglycerol, and triolein (molar ratio 4.5:4.5:1:1), there was only a single continuous bilayer membrane for each solid core liposome.Type: GrantFiled: February 2, 1987Date of Patent: June 13, 1989Assignee: The University of Tennessee Research CorporationInventor: Leaf Huang
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Patent number: 4828325Abstract: An orthotic support system is embodied as cooperating seat and back cushion elements for assembly into a wheelchair frame. These cushion elements are custom-fitted to the individual patient by injecting an incipiently reacting and foaming, fluorocarbon-blown polyurethane chemical system into the space between a rigid mold box and an elastic membrane which is fitted over the open face of the mold box and which is deformably engaged by the appropriate portions of the patient's torso. The foaming mixture is injected in predetermined excess volume and expands against the physical resistance of the patient's body where contact is made with the corresponding regions of the elastic membrane; and this forcible engagement produces selective densification of the foam where a high degree of body support is required. Elsewhere, the foam expands more freely and stretchably inflates the membrane to generate graduatedly less dense regions matably contoured to fit or partially embrace the patient.Type: GrantFiled: September 29, 1987Date of Patent: May 9, 1989Assignee: University of Tennessee Research CorporationInventor: William R. Brooks
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Patent number: 4818528Abstract: A vaccine for immunizing cattle against infectious bovine keratoconjunctivitis which contains protein fragments having an antigenic site common to pili of pathogenic strains of Moraxella bovis and is produced by reacting purified Moraxella bovis pili with cyanogen bromide.Type: GrantFiled: February 6, 1987Date of Patent: April 4, 1989Assignee: The University of Tennessee Research CorporationInventors: Wallace H. Green, Leon N. D. Potgieter
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Patent number: 4818185Abstract: An electromagnetic pump and generator apparatus for electrically conductive fluids includes a conduit for containing the conductive fluid and apertures in the sides of the conduit. A fluid circuit is defined outside the conduit for containing a quantity of the conducting fluid and is configured so that the conducting fluid in the circuit is in fluid communication with the conducting fluid in the conduit. When used as a pump, a magnet produces a magnetic field across the conduit between the apertures and a device is employed to produce an electric current in the conducting fluid in the fluid circuit. Current in the conducting fluid in the fluid circuit flow across the conduit through the conducting fluid contained therein between the apertures. The current flowing across the conduit together with the magnetic field imparts a force on the conducting fluid in the conduit causing the fluid to be pumped.Type: GrantFiled: October 13, 1987Date of Patent: April 4, 1989Assignee: The University of Tennessee Research CorporationInventor: Igor Alexeff
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Patent number: 4808518Abstract: Recovery of antigen from cells containing an intracellular parasite, in particular a virus, by extracting the antigen from the cells with a hypertonic salt solution. CMV antigen extracted in this manner may be supported on particles and used in an agglutination assay for CMV antibody.Type: GrantFiled: February 11, 1985Date of Patent: February 28, 1989Assignee: University of Tennessee Research CorporationInventors: Preston H. Dorsett, Robert F. Naegele, Terry S. Ratcliffe
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Patent number: 4807990Abstract: A method and apparatus are disclosed for measuring a velocity component of a moving fluid. Coherent light at two different wavelengths is directed into the moving fluid to create a space-and-time modulated optical field within a sample volume and to cause a chemical component of the moving fluid to fluoresce. Measurement of temporal and/or spatial characteristics of the resulting fluorescence is employed to determine the velocity component of the moving field.Type: GrantFiled: October 28, 1986Date of Patent: February 28, 1989Assignee: University of Tennessee Research CorporationInventor: Dennis R. Keefer
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Patent number: 4806663Abstract: The disclosure relates to compounds of the formula ##STR1## and pharmaceutically acceptable addition salts thereof wherein R.sub.1 represents hydrogen, R.sub.1 represents a group having the formula --OR.sub.2 in which R.sub.2 is a lower alkyl group or an aryl group, or R.sub.1 represents a group having the formula ##STR2## in which R.sub.3 is hydrogen, a lower alkyl group, or an aryl group, wherein R.sub.4 is a lower alkyl group containing 1 to 6 carbon atoms, wherein R.sub.5 is either hydrogen or methyl, wherein NR.sub.6 is a group selected from the class consisting of amino, lower mono and dialkylamino, piperidino, pyrrolidino, and morpholino groups and wherein Y.sub.1 and Y.sub.2 are identical and are hydrogen or a halogen. Compounds in accordance with the invention are useful as vasodilators and as antiarrythmic agents.Type: GrantFiled: April 6, 1987Date of Patent: February 21, 1989Assignee: The University of Tennessee Research CorporationInventors: Thomas P. Kennedy, George W. Kabalka
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Patent number: 4804624Abstract: A latex agglutination assay to detect antibodies against pseudorabies virus is provided. The test assays swine serum or plasma for the presence of pseudorabies virus antibody which is indicative of an acute or previous infection or vaccination. The latex reagent is a suspension of latex particles, 0.9 microns in diameter, that have adsorbed thereon antigens from disrupted and solubilized pseudorabies virus. When this material is mixed by rotation with serum containing pseudorabies antibodies, the latex will agglutinate forming visible clumps. In the absence of antibody, the latex suspension will remain smooth and evenly dispersed.Type: GrantFiled: October 22, 1984Date of Patent: February 14, 1989Assignee: The University of Tennessee Research CorporationInventor: Preston H. Dorsett