Abstract: Methods are described for detecting pathogens, infectious diseases, and physiological conditions by quantifying change of impedance over time of when a biological sample is applied onto a lab-on-a-chip. The lab-on-a-chip utilizes alternating-current electrokinetic (ACEK) phenomena such that molecules move or are carried in an electric field generated by the application of an electrical signal of predetermined magnitude and frequency to an electrode array of the lab-on-a-chip.

Abstract: Disclosed are devices, methods, and systems for securing an object to a subject, such as bandages and dressings over wounds, keeping wounds apposed, maintaining pressure on wounds, and stretching skin. The device comprises a closeable, needle-tipped anchor; a lacing loop; and, a swivel connector that connects the anchor and lacing loop and permits rotation and sliding of the connecting parts. The needle tipped anchor is inserted through the tissues, and its tip is then locked in position with the clasp. Multiple devices may be placed around the wound along its edges. Lacing material is engaged in the lacing loop by passage of the lacing material through the lacing loop. The swivel permits rotation and also permits sliding at its connections with the anchor and lacing loop. This range of motion allows positioning and tightening of the laces without inappropriate torque on tissue to which the anchor is attached.

Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.

Abstract: A radiation detector may include a scintillator, a light source, and a sensor. The scintillator may include various scintillation materials capable of converting non-visible radiation (incoming radiation) into visible light. The sensor may be placed in adjacent or in close proximity to the scintillator, such that any converted visible light may be detected or measured by the sensor. The light source may be placed in adjacent or in close proximity to the scintillator, such that light from the light source may interact with defects in the scintillator to minimize interference on the conversion of non-visible radiation into visible light caused by the defects.

Abstract: A scintillator element is disclosed where the scintillator element includes a scintillator formed of a scintillation material capable of converting non-visible radiation into scintillation light, wherein the scintillator has a plurality of laser-etched micro-voids within the scintillator, each micro-void having an interior surface, and an intrinsic reflective layer is formed on the interior surface of at least some of the micro-voids, wherein the intrinsic reflective layer is formed from the scintillation material.

Abstract: Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient IgA1. Optionally, the methods comprise providing a biological sample from the subject and detecting in the sample a mutation in a IGH gene, wherein the mutation is in a nucleotide sequence encoding a complementarity determining region 3 (CDR3) of a IGH variable region. Optionally, the methods comprise determining a level of IgG specific for a galactose-deficient IgA1 in the subject. Also provided are methods of treating or reducing the risk of developing IgA nephropathy in a subject.

Abstract: Immunogenic group A streptococcus M-related polypeptides and peptides and immunogenic compositions comprising these M-related polypeptides and peptides are provided herein that evoke cross-opsonic and cross-protective anti-GAS and anti-SDSE antibodies in animals. Also provided are preparations comprising immunogenic compositions that comprise M-related polypeptides, peptides, or fusion proteins and that further comprise at least one additional group A streptococcus immunogen, such as an M peptide or Spa peptide.

Abstract: Methods, systems and computer-readable storage media relate to determining individualized treatment planning margins. The methods may include processing motion data of a target obtained from at least one marker for one or more periods. Each period may include a plurality of time intervals. The processing may include processing the motion data to determine an isocenter for each time interval along at least one of the axes of motion. The axes can include the x axis, the y axis, and/or the z axis. The method may include determining motion prediction data for each of the at least one of the axes; and determining treatment planning margins for each of the at least one of the axes based on the motion prediction data. The individualized treatment margins can be smaller and more optimal because the treatment margins can incorporate patient specific patterns of motion of a target (e.g., an organ).

Abstract: A combined thermal neutron detector and gamma-ray spectrometer system, including: a detection medium including a lithium chalcopyrite crystal operable for detecting thermal neutrons in a semiconductor mode and gamma-rays in a scintillator mode; and a photodetector coupled to the detection medium also operable for detecting the gamma rays. Optionally, the detection medium includes a 6LiInSe2 crystal. Optionally, the detection medium comprises a compound formed by the process of: melting a Group III element; adding a Group I element to the melted Group III element at a rate that allows the Group I and Group III elements to react thereby providing a single phase I-III compound; and adding a Group VI element to the single phase I-III compound and heating; wherein the Group I element includes lithium.

Abstract: Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A is an alkali metal, such as Li, Na, K, Rb, Cs or any combination thereof; B is an alkali earth metal, such as Be, Mg, Ca, Sr, Ba or any combination thereof; and X is a halide, such as Cl, Br, I, F or any combination thereof. Radiation detectors comprising the novel metal halide scintillators and other ternary metal halides, such as those of the formulas A2EuX4 and AEu2X5, wherein A is an alkali metal and X is a halide, are also described.

Abstract: This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

Abstract: The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.

Abstract: Methods and systems for suppressing coking in dehydration reactions catalyzed by solid acids. Dehydration reactions catalyzed by one or more solid acid catalysts can be performed in the presence of a super critical carbon dioxide medium which prevents or minimizes coking of the solid acid catalysts. Methods and systems are provided for producing glycerol products, such as acrolein, acrylic acid, acetol, by performing a dehydration reaction of glycerol using one or more solid acid catalysts in the presence of a super critical carbon dioxide reaction medium. Such methods and systems can be nm for extended periods of time, or continuously, due to catalyst regeneration and/or recycling. Such methods and systems are configured to produce glycerol products from crude glycerol feedstock with minimal pretreatment.

Abstract: Mobile telecommunications or personal computing apparatus may be specially programmed for predicting whether an unknown biological specimen of an individual to be identified originates from or is related to a member of a particular family. The apparatus may comprise an input device including a barcode reader and a virtual touch screen keyboard whereby DNA profile or mass spectrometry test data may be entered among other data for an individual to be identified, for example, a missing person, victim, crime perpetrator or other unknown individual in hypothetical relationship to another individual or to a family pedigree of typed family members. The typed family pedigree in relation to the individual to be identified in hypothetical relation may be displayed on an output display of the apparatus including at least two different profile typing indicators for each displayed member of the pedigree.

Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: A membrane useful in gas separation, the membrane comprising a cross-linked polysiloxane structure having a cross-link density of about 0.1×10?5 mol/cm3 to about 6×10?5 mol/cm3, where, in particular embodiments, the cross-linked polysiloxane structure has the following general structure: wherein R1, R2, R3, R4, R5, and R6 are independently selected from hydrocarbon groups having at least 1 and up to 6 carbon atoms; A1 and A2 are independently selected from cyclic hydrocarbon groups; L1 and L2 are linking groups or covalent bonds; n is an integer of at least 1; r and s are independently selected from integers of at least 1; and p is an integer of at least 10. The invention also includes methods for making and using the above-described membranes for gas separation.

Abstract: Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

Abstract: Systems, methods and a lab-on-a-chip product are described for the detection of pathogens, infectious diseases and physiological conditions by quantifying change over time of one of capacitance or impedance when a biological sample is loaded onto the chip. The lab-on-a-chip utilizes AC electrokinetic phenomena such that molecules move or are carried in an electric field generated by the application of a signal of predetermined voltage and frequency to an electrode array. In particular, an electrode array of a conductive material is constructed on a substrate that may comprise silicon or quartz/glass or other known substrate, in one embodiment, a molecular probe comprising a bacterial antigen, an antibody against pathogen an antibody against protein or other biomarker is dispersed on the electrode array and blocked.

Abstract: The present disclosure is directed to a group of newly discovered intrinsic scintillation compounds. As intrinsic scintillators, these compounds do not require an external activator as a dopant. The new scintillators may include members of two elpasolite families with the general exemplary formulas of A2BMX(6-y)X?y and A3MX(6-y)X?y, (0<y<6).