Patents Assigned to University of Texas Southwestern Medical Center at Dallas
  • Methods of identifying agents that affect cleavage of amyloid-beta precursor protein
    Publication number: 20030022171
    Abstract: The present invention provides methods of identifying agents that affect the cleavage of amyloid-&bgr; precursor protein (APP) and related vectors, cells and kits, as well as agents identified by the method.
    Type: Application
    Filed: March 30, 2001
    Publication date: January 30, 2003
    Applicant: THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS
    Inventors: Thomas C. Sudhof, Xinwei Cao
  • Ligands of the neuropeptide receptor HFGAN72
    Patent number: 6001963
    Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: December 14, 1999
    Assignees: SmithKline Beecham Corporation, University of Texas Southwestern Medical Center at Dallas
    Inventors: Derk J. Bergsma, Masashi Yanagisawa
  • Ligands of the neuropeptide receptor HFGAN72
    Patent number: RE40988
    Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: November 17, 2009
    Assignees: SmithKline Beecham Corporation, University of Texas Southwestern Medical Center at Dallas
    Inventors: Derk J. Bergsma, Masahi Yanigasawa