Patents Assigned to University of the Queensland
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Patent number: 11105802Abstract: The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.Type: GrantFiled: December 10, 2013Date of Patent: August 31, 2021Assignees: SEATTLE CHILDREN'S HOSPITAL, The University of QueenslandInventors: Yadveer Grewal, Gerard A. Cangelosi, Muhammad J. A. Shiddiky, Matt Trau
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Patent number: 11095490Abstract: A transmitter of a DFT-based communications system including an orthogonal precoder for transforming modulated data symbols using a unitary transform, wherein the data 5 symbols are mapped to subcarriers of the transmitter and the computational complexity of the transform is linear with respect to the number of the subcarriers.Type: GrantFiled: August 7, 2017Date of Patent: August 17, 2021Assignee: The University of QueenslandInventor: Ian Vaughan Lyndon Clarkson
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Patent number: 11045502Abstract: Disclosed are methods for isolating endothelial progenitor cells (EPC). More particularly, the present invention discloses methods for isolating endothelial progenitor cells that exhibit self-renewal and differentiation capacity. The isolated cellular population of the present invention is useful in a wide range of clinical and research setting including inter alia, the in vitro or in vivo generation of endothelial cells and the therapeutic or prophylactic treatment of a range of conditions via the administration of these cells. Also facilitated is the isolation of endothelial progenitor cells for research purposes such as in vitro based screening systems for testing the therapeutic impact and/or toxicity of potential treatment or culture regimes to which these cells may be exposed to. The present invention also discloses methods for isolating mesenchymal stem cells, in particular mesenchymal stem cells of fetal and/or maternal origin.Type: GrantFiled: November 9, 2018Date of Patent: June 29, 2021Assignee: The University of QueenslandInventors: Jatin Patel, Paul Kiarash Khosrotehrani, Nicholas Maxwell Fisk
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Patent number: 11033507Abstract: The invention relates, in part, to a method of producing silica vesicles including under controlled conditions to thereby heavily influence the morphology and characteristics of the vesicles. The vesicles are shown to be effective as delivery agents for chemical and biological agents. They are also shown to be useful in methods of treatment and as components of an immunogenic composition.Type: GrantFiled: December 19, 2014Date of Patent: June 15, 2021Assignee: The University of QueenslandInventors: Chengzhong Yu, Neena Mitter, Jun Zhang
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Patent number: 11027831Abstract: A safety rotor system for an aircraft including a flight rotor that is rotationally driven by a drive, the system including: a safety rotor that is rotationally driven during rotation of the flight rotor, the safety rotor including one or more safety members traversing a path outward of the flight rotor so that an object approaching the flight rotor through the path contacts one of the safety members before contacting the flight rotor, wherein the safety rotor decelerates when one of the safety members contacts an object; a sensor for detecting rotation of the safety rotor; and a controller configured to: determine, using the sensor, a deceleration of the safety rotor corresponding to one of the safety members contacting an object; and cause the rotation of the flight rotor to cease in response to detecting the deceleration of the safety rotor.Type: GrantFiled: July 8, 2016Date of Patent: June 8, 2021Assignee: The University of QueenslandInventor: Pauline Edith Iyan Pounds
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Patent number: 11021408Abstract: A nanoparticulate fertilizer is provided. The fertilizer may comprise water soluble nanoparticles having a contact area to total surface area ratio greater than 1:4. The nanoparticles may have an overall positive surface charge in water. The fertilizer may be suitable for application as a seed coat. Also provided is a method of applying a seed coat, and a method of fertilizing a plant.Type: GrantFiled: October 16, 2018Date of Patent: June 1, 2021Assignee: The University of QueenslandInventors: Longbin Huang, Anh Van Nguyen, Victor Rudolph, Gordon Xu
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Patent number: 10947271Abstract: The invention concerns agents with antibacterial activity, their production and use in the treatment of bacterial infections in animals, including man. The agents are derivatives of vancomycin-type antibiotics, of structure X—W-L-V, wherein X is hydrogen, acetyl or a lipophilic membrane-insertive element, W is a basic peptide or basic amino acid; L is a linking group and V is a glycopeptide moiety which inhibits peptidoglycan biosynthesis in bacteria.Type: GrantFiled: February 10, 2015Date of Patent: March 16, 2021Assignee: THE UNIVERSITY OF QUEENSLANDInventors: Matthew Cooper, Mark Blaskovich
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Patent number: 10933049Abstract: The present invention discloses the use of a complement 3a receptor (C3aR) antagonist and a mobilizer of hematopoietic stem cells and/or progenitor cells in methods and compositions for stimulating or enhancing the development, mobilization, proliferation and/or differentiation of a neutrophil-containing leukocyte population that inhibits growth and/or spread of a tumor and for treating or preventing a hyperproliferative cell disorder.Type: GrantFiled: June 1, 2016Date of Patent: March 2, 2021Assignee: The University of QueenslandInventors: Trent Woodruff, Barbara Rolfe
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Patent number: 10900022Abstract: A method is provided for simultaneously producing both nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting intermediate mesoderm cells with: fibroblast growth factor (9) and/or fibroblast growth factor (20) and optionally, one or more selected from the group consisting of. bone morphogenic protein 7; heparin: a Wnt agonist; retinoic acid; and an RA antagonist. The concentrations of Writ agonist, retinoic acid and/or RA antagonist may be manipulated to favour the relative production of nephron progenitor cells and ureteric epithelial progenitor cells. The intermediate mesoderm cells are ultimately derived from human pluripotent stem cells via a posterior primitive streak stage. The nephron progenitor cells and ureteric epithelial progenitor cells may have end uses such as for kidney repair and regeneration, bioprinting of kidneys and screening compounds for nephrotoxicity.Type: GrantFiled: June 13, 2014Date of Patent: January 26, 2021Assignee: The University of QueenslandInventors: Melissa Little, Minoru Takasato
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Patent number: 10881712Abstract: The invention relates to disulfide-rich peptides derived from spider venom and their use, particularly as neuroprotective agents. The invention also relates to nucleic acid molecules encoding the peptides as well as constructs and host cells comprising those nucleic acid molecules.Type: GrantFiled: October 11, 2019Date of Patent: January 5, 2021Assignees: The University of Queensland, Monash UniversityInventors: Glenn Frederick King, Lachlan Douglas Rash, Irene Chassagnon, Sandy Steffany Pineda Gonzalez, Robert Edward Widdop, Claudia Ann Ireland
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Publication number: 20200339684Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.Type: ApplicationFiled: July 9, 2020Publication date: October 29, 2020Applicants: DENDROCYTE BIOTECH PTY LTD, THE UNIVERSITY OF QUEENSLAND, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Therese Ann Seldon, David John Munster, Derek Nigel John Hart, Martina Louise Jones, Trent Phillip Munro, Stephen Michael Mahler, Yu Zhou, James D. Marks
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Patent number: 10781255Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.Type: GrantFiled: November 9, 2017Date of Patent: September 22, 2020Assignees: DENDROCYTE BIOTECH PTY LTD, THE UNIVERSITY OF QUEENSLAND, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Therese Ann Seldon, David John Munster, Derek Nigel John Hart, Martina Louise Jones, Trent Phillip Munro, Stephen Michael Mahler, Yu Zhou, James D. Marks
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Patent number: 10738586Abstract: A method for removing water from a coal seam gas well or shale gas well, the coal seam gas well or shale gas well including an outer casing into which coal seam gas and water flow near the lower region of the coal seam gas well, the method includes delivering pressurized methane into a lower region of the gas well, the pressurized methane acting to lift water from the lower region of the gas well, and cause it to flow upwards towards the surface. A system is also provided for removing water from a coal seam gas well or shale gas well. The method may be retro-fitted to existing CSG wells or shale gas wells.Type: GrantFiled: June 7, 2019Date of Patent: August 11, 2020Assignee: The University of QueenslandInventors: Victor Rudolph, Mahshid Firouzi, Brent Greenway
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Patent number: 10716877Abstract: A composite material comprising an elastomer and nanocellulose. The nanocellulose may comprise a nanocellulose material derived from plants having C4 leaf anatomy, or a nanocellulose material derived from a plant material having a lesser amount of lignin than hemicellulose, or a nanocellulose having a hemicellulose content of from 25% to 55% by weight of the nanocellulose material, or a nanocellulose comprising nanofibrils having a diameter of up to 5 nm, or a nanocellulose comprising nanocellulose material of plant origin comprising nanocellulose particles or fibres having an aspect ratio of at least 250, or the composite material having a stiffness of not greater than 2.5 times the stiffness of the elastomer without the nanocellulose material being present, or the nanocellulose particles or fibres being derived from a plant material having a hemicellulose content of 30% or higher (w/w). The nanocellulose may be derived from arid Spinifex.Type: GrantFiled: December 7, 2015Date of Patent: July 21, 2020Assignee: The University of QueenslandInventors: Nasim Amiralian, Darren James Martin
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Patent number: 10704197Abstract: A nanocellulose material of plant origin comprising nanocellulose particles or fibres derived from a plant material having a hemicellulose content of 30% or higher (w/w) (calculated as a weight percentage of the lignocellulosic components of the material). The nanocellulose may have an aspect ratio of greater than 250. The nanocellulose may be derived from plant materials having C4 leaf morphology. The plant material may be obtained from arid Spinifex. The nanocellulose can be made using mild processing conditions.Type: GrantFiled: November 21, 2014Date of Patent: July 7, 2020Assignee: The University of QueenslandInventors: Darren James Martin, Pratheep Kumar Annamalai, Nasim Amiralian
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Patent number: 10695406Abstract: Disclosed are compositions and methods for modulating oxidative and/or endoplasmic reticulum (OER) stress. More particularly, the present invention discloses compositions and methods that target OER stress inhibitors to pancreatic cells for treating diseases associated with oxidative and/or OER stress, including metabolic disorders such as diabetes.Type: GrantFiled: May 27, 2015Date of Patent: June 30, 2020Assignee: The University of QueenslandInventors: Michael McGuckin, Johannes Prins, Sumaira Hasnain
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Patent number: 10676743Abstract: Aspects of the present invention relate to a plant-protecting RN Ai composition comprising plant-protecting double-stranded RNA adsorbed onto Layered Double Hydroxide (LDH) particles, and to methods for protecting a plant comprising the step of administering to a plant an RNAi composition comprising plant-protecting double-stranded RNA adsorbed onto LDH particles.Type: GrantFiled: March 14, 2014Date of Patent: June 9, 2020Assignee: The University of QueenslandInventors: Neena Mitter, Zhi Ping Xu, Gao Qing Lu
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Patent number: 10662503Abstract: A method of selectively leaching a metal such as nickel from an ore or ore processing intermediate comprising the metal and cobalt. The ore or ore processing intermediate is contacted with an acidic leach solution comprising an amount of an oxidising agent sufficient to oxidise a major portion of the cobalt to thereby cause it to be stabilised in the solid phase while a major portion of the metal is dissolved for subsequent recovery.Type: GrantFiled: August 19, 2016Date of Patent: May 26, 2020Assignee: THE UNIVERSITY OF QUEENSLANDInventors: James Vaughan, William Hawker
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Patent number: 10662446Abstract: Disclosed herein are new strains of Propionibacterium and methods for the biosynthetic production of propionic acid.Type: GrantFiled: September 29, 2016Date of Patent: May 26, 2020Assignee: The University of QueenslandInventors: Carlos H. Luna-Flores, Lars K. Nielsen, Esteban Marcellin, Christopher C. Stowers, Bianca F. Martins, Brad M. Cox
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Patent number: 10662229Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides from the venom of the tarantula Pamphobeteus nigricolor and their use in methods of inhibiting Nav1.7 and for treating or preventing conditions associated with Nav1.7 activity such as neuropathic, inflammatory and nociceptive pain.Type: GrantFiled: June 21, 2017Date of Patent: May 26, 2020Assignee: The University of QueenslandInventors: Paul Alewood, Zoltan Dekan, Jennifer Deuis, Richard Lewis, Irina Vetter