Patents Assigned to University of the Ryukyus
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Publication number: 20240398775Abstract: The present invention provides a pharmaceutical composition for use in treating cognitive decline. The pharmaceutical composition of the present invention comprises an antagonist of an AMPA receptor. The present invention also provides pharmaceutical compositions for use in treating a disease or condition associated with NMDA insensitivity in an NMDA-insensitive subject. The present invention can be useful, for example, in a subject in which intracellular calcium influx by stimulation with NMDA and glycine is inhibited in an NMDA receptor from which inhibition of activation by Mg ions has been released. The present invention further provides a pharmaceutical composition for use in treating overweight and obesity.Type: ApplicationFiled: September 15, 2022Publication date: December 5, 2024Applicant: University of the RyukyusInventor: Shogo ISHIUCHI
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Publication number: 20240317853Abstract: It is an object of the present invention to provide an antibody that binds to CADM1 expressed on a cell, wherein the antibody alone is capable of inducing internalization of the antibody and the CADM1 into the cell. Specifically, the present invention relates to an antibody binding to CADM1 (Cell adhesion molecule 1), in which the antibody binds to CADM1 on the surface of a cell and induces internalization of the antibody and the CADM1 into the cell, or an antigen-binding fragment thereof.Type: ApplicationFiled: May 10, 2022Publication date: September 26, 2024Applicants: The University of Tokyo, University of the RyukyusInventors: Kazumi NAKANO, Toshiki WATANABE, Kouhei TSUMOTO, Aki TANABE, Yoshiaki TAKAHASHI
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Publication number: 20210196747Abstract: Provided is a metabolism improving agent that contains, for example, an alkalizing agent such as an acidosis improving agent or a urinary alkalizing agent as an active ingredient, and has actions such as improvement of insulin resistance, improvement of pituitary and adrenal functions, and reduction of visceral fat accumulation.Type: ApplicationFiled: May 24, 2019Publication date: July 1, 2021Applicants: University of the Ryukyus, Nippon Chemiphar Co., Ltd.Inventors: Hiroaki MASUZAKI, Hideki NAKAMURA, Toshitake HIRAI, Kaoru HARA, Takashi KANDA, Satomi YAMASAKI, Tadashi KOBAYASHI, Koichiro NISHIOKA
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Publication number: 20200407690Abstract: Adipose-derived stem cells are isolated and extracted from an adipose tissue without using collagenase. An adipose tissue is covered with a nonwoven fabric sheet having sufficient interfiber space and pressed by an appropriate force. Thus, the adipose tissue infiltrates among fibers of the nonwoven fabric and then comes into contact with fibers surrounding the same. By immersing the nonwoven fabric as such in a culture medium, a number of adipose-derived stem cells are allowed to crawl out from the adipose tissue and then adhered to the fiber surface.Type: ApplicationFiled: February 27, 2019Publication date: December 31, 2020Applicants: University of the Ryukyus, ORTHOREBIRTH CO. LTD.Inventors: Hiroshi Sunami, Yusuke Shimizu, Naoko Futenma, Masashi Makita, Naoya Osaka
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Patent number: 10863752Abstract: A plasma sterilization apparatus includes a voltage-applying unit that applies a voltage to a sterilization target having conductivity; a pair of electrodes that apply, in a discharged state, the voltage applied by the voltage-applying unit to the sterilization target via a dielectric; and a position changing unit that changes a relative position between the pair of electrodes and the sterilization target.Type: GrantFiled: October 27, 2016Date of Patent: December 15, 2020Assignees: National Institute of Technology, Saga University, University of the RyukyusInventors: Yoshihito Yagyu, Tatsuya Misawa, Akikazu Sakudo
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Patent number: 10653740Abstract: A method of treating fatty liver comprising administering an effective amount of a plant belonging to a genus Cirsium to a patient in need of the treatment.Type: GrantFiled: February 23, 2018Date of Patent: May 19, 2020Assignees: Amino Up Co., Ltd., University of the Ryukyus, NPO Amami Functional Foods Study GroupInventors: Hirosuke Oku, Yasuo Kamiyama, Masashi Inafuku
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Patent number: 10018377Abstract: A solar light (heat) absorption material which has an excellent solar light (heat) absorbing ability and a simple structure, and may be used as a low-cost and high-performance heat absorption/accumulation material. Also, a solar light (heat) absorption/control building component including the solar light (heat) absorption material that allows for easy change of its solar light (heat) absorption/control ability. The material includes particles dispersed into a liquid medium having a specific heat ranging from 0.4 to 1.4 cal/g/° C. and a melting point of 5° C. or lower. The dispersed particles have L*value of 30 or less as determined by the CIE-Lab color system (light source D65).Type: GrantFiled: August 20, 2014Date of Patent: July 10, 2018Assignees: University of the Ryukyus, Osaka Gas Co., Ltd.Inventors: Yoshikazu Kondo, Masami Ueno, Yoshinobu Kawamitsu, Junichiro Tsutsumi
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Patent number: 8658226Abstract: The present invention provides an agent having anti-Helicobacter pylori activity that is effective for the treatment, prevention or improvement of diseases associated with Helicobacter pylori and contains as an active ingredient thereof an extract of a plant belonging to the Labiatae family. The agent having anti-Helicobacter pylori activity of the present invention has superior heat stability and allows the obtaining of elimination effects in a short period of time.Type: GrantFiled: October 30, 2009Date of Patent: February 25, 2014Assignees: Japan Royal Jelly Co., Ltd., University of the RyukyusInventors: Yoshiya Sato, Hiromu Toma, Hironori Iwasaki, Kikuji Yamaguchi
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Publication number: 20140030353Abstract: The invention provides a composition for prevention or treatment of a disease associated with the production of an autoantibody. Specifically, it provides a composition for the prevention or treatment of a disease associated with the production of an autoantibody, which comprise royal jelly as an active ingredient.Type: ApplicationFiled: September 27, 2013Publication date: January 30, 2014Applicant: University of the RyukyusInventors: Yoshiya SATO, Md. Kaiisar MANNOOR, Isao SHIMABUKURO, Kikuji YAMAGUCHI
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Patent number: 8580274Abstract: An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the immunogenicity of the vaccine or capable of enhancing the immunostimulating effect of the adjuvant as well as a vaccine or adjuvant utilizing the same. Said drug delivery vehicle contains a multimeric protein having a coiled coil structure and a ligand molecule to a receptor of an immune cell.Type: GrantFiled: February 10, 2010Date of Patent: November 12, 2013Assignee: University of the RyukyusInventors: Takeshi Arakawa, Takeshi Miyata, Goro Matsuzaki, Takafumi Tsuboi
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Patent number: 8216433Abstract: A plasma generator in which the variation of the impedance in the cavity before and after plasma is ignited is less and hardly affected by the shape of the cavity, and the ignitability of the plasma is improved and a method of generating plasma using the plasma generator are provided. The plasma generator comprises a nonconductive gas flow pipe (1) for introducing a gas (9) for generating plasma and discharging it into the atmosphere and a conductive antenna pipe (2) surrounding the gas flow pipe. A microwave (7) is applied to the antenna pipe to change the gas in the gas flow pipe into plasma. The plasma generator is characterized in that a slit (3) with a predetermined length is formed in the antenna pipe (2) along the axial direction of the gas flow pipe. Preferably, the plasma generator is characterized in that the length of the slit is an integral multiple of the half-wave length of the applied microwave.Type: GrantFiled: February 17, 2007Date of Patent: July 10, 2012Assignee: University of the RyukyusInventor: Akira Yonesu
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Publication number: 20120100165Abstract: An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the immunogenicity of the vaccine or capable of enhancing the immunostimulating effect of the adjuvant as well as a vaccine or adjuvant utilizing the same. Said drug delivery vehicle contains a multimeric protein having a coiled coil structure and a ligand molecule to a receptor of an immune cell.Type: ApplicationFiled: February 10, 2010Publication date: April 26, 2012Applicant: University of the RyukyusInventors: Takeshi Arakawa, Takeshi Miyata, Goro Matsuzaki, Takafumi Tsuboi
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Publication number: 20090317295Abstract: It is intended to provide a sterilizer, which aim is at efficiently sterilizing a subject such as a container by using active oxygen generated with the use of plasma, and a sterilization method using the same. In particular, it is intended to develop a technique for stably generating active oxygen with the use of plasma and thus provide a sterilizer, which enables, if necessary, stable plasma formation and active oxygen generation in the atmosphere and can inhibit thermal damages caused by the plasma on a subject to be sterilized, and a sterilization method using the same.Type: ApplicationFiled: March 7, 2007Publication date: December 24, 2009Applicants: Saga University, University of the Ryukyus, The Coca-Cola CompanyInventors: Akira Yonesu, Nobuya Hayashi, Yoshihisa Tachibana
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Publication number: 20090260972Abstract: A plasma generator in which the variation of the impedance in the cavity before and after plasma is ignited is less and hardly affected by the shape of the cavity, and the ignitability of the plasma is improved and a method of generating plasma using the plasma generator are provided. The plasma generator comprises a nonconductive gas flow pipe (1) for introducing a gas (9) for generating plasma and discharging it into the atmosphere and a conductive antenna pipe (2) surrounding the gas flow pipe. A microwave (7) is applied to the antenna pipe to change the gas in the gas flow pipe into plasma. The plasma generator is characterized in that a slit (3) with a predetermined length is formed in the antenna pipe (2) along the axial direction of the gas flow pipe. Preferably, the plasma generator is characterized in that the length of the slit is an integral multiple of the half-wave length of the applied microwave.Type: ApplicationFiled: February 17, 2007Publication date: October 22, 2009Applicant: University of the RyukyusInventor: Akira Yonesu
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Patent number: 7544361Abstract: A heteropentamer composed of a fusion monomer (32) comprising a fusion protein of an antigenic amino acid sequence and an amino acid sequence of a monomer of a mucous membrane-binding protein and a nonfusion monomer (20) of an amino acid sequence of a monomer of a mucous membrane-binding protein. A homopentamer composed of a fusion monomer including a fusion protein of an antigen derived from an envelope protein of Japanese encephalitis virus and an amino acid sequence of a monomer of a mucous membrane-binding protein. These heteropentamer and the homopentamer can be used as a vaccine.Type: GrantFiled: July 23, 2004Date of Patent: June 9, 2009Assignees: Advanced Medical Biological Science Institute Co. Ltd., University of the RyukyusInventors: Takeshi Arakawa, Masanao Kikukawa, Isao Shimabukuro, Masayuki Tadano, Yasunobu Matsumoto, Naotoshi Tsuji, Yoshiya Sato
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Patent number: 6444648Abstract: A leishmaniasis preventing and/or treating agent having 2-deoxy-2-[(3S)-(9-phenylnonanoyloxy)tetradecanoyl]amino-3-O-(9-phenylnonanoyl)-4-O-sulfo-&agr;-D-glucopyranose represented by a formula (I) or a non-toxic salt thereof as an effective ingredient. 2-deoxy-2-[(3S)-(9-phenylnonanoyloxy)tetradecanoyl]amino-3-O-(9-phenylnomanoyl)-4-O-sulfo-&agr;-D-glucopyranose represented by a formula (I) or a non-toxic salts effectively functions to prevent and/or treat leishmaniasis, and is a highly safe compound.Type: GrantFiled: July 17, 2000Date of Patent: September 3, 2002Assignee: University of the RyukyuInventor: Shigeo Nonaka