Patents Assigned to University of the Sciences in Philadelphia
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Patent number: 10894813Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.Type: GrantFiled: August 20, 2018Date of Patent: January 19, 2021Assignee: University of the Sciences of PhiladelphiaInventors: Zhiyu Li, Michelle Parker
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Patent number: 10796894Abstract: An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure. The heater is for heating the channel, and the channel is configured to generate charged particles of a sample in response to the sample being introduced into the channel.Type: GrantFiled: November 12, 2018Date of Patent: October 6, 2020Assignees: University Of The Sciences in Philadelphia, Wayne State UniversityInventors: Sarah Trimpin, Charles Nehemiah McEwen, Vincent Salvatore Pagnotti
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Patent number: 10677914Abstract: In one embodiment, a method for detecting buried objects includes receiving ground penetrating radar (GPR) signals captured at discrete locations along a surface of a medium in which an object may be buried, computing parameters based on the received GPR signals that are indicative of the proximity of a buried object, plotting the computed parameters as a function of location, determining an apex of a hyperbola that results from the plotting of the computed parameters, and designating a location at which the apex occurs as an estimated location of the buried object.Type: GrantFiled: December 5, 2018Date of Patent: June 9, 2020Assignees: University of South Florida, University of the Sciences in PhiladelphiaInventors: Chris P. Tsokos, Abolfazl Saghafi, Sajad Jazayeri, Sanaz Esmaeili
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Patent number: 10265413Abstract: Disclosed herein are high molecular weight compounds comprising gelatin and doxorubicin, where the gelatin is covalently linked to doxorubicin through a cleavable linker. The cleavable linker can be cleaved under appropriate physiological conditions, and thus lead to the freeing of doxorubicin. The free doxorubicin can then exert its cytotoxic effects on cancer cells. Disclosed herein are methods of making the high molecular weight gelatin-doxorubicin conjugates and methods of use of the same.Type: GrantFiled: October 30, 2015Date of Patent: April 23, 2019Assignee: UNIVERSITY OF THE SCIENCES IN PHILADELPHIAInventors: Clyde M. Ofner, III, Chris Cammarata, Brian Rhodes, Darren Wu
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Publication number: 20190096649Abstract: An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure.Type: ApplicationFiled: November 12, 2018Publication date: March 28, 2019Applicants: UNIVERSITY OF THE SCIENCES IN PHILADELPHIA, WAYNE STATE UNIVERSITYInventors: Sarah TRIMPIN, Charles Nehemiah McEWEN, Vincent Salvatore PAGNOTTI
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Patent number: 10175350Abstract: In one embodiment, a method for detecting buried objects includes receiving ground penetrating radar (GPR) signals captured at discrete locations along a surface of a medium in which an object may be buried, computing parameters based on the received GPR signals that are indicative of the proximity of a buried object, plotting the computed parameters as a function of location, determining an apex of a hyperbola that results from the plotting of the computed parameters, and designating a location at which the apex occurs as an estimated location of the buried object.Type: GrantFiled: June 28, 2018Date of Patent: January 8, 2019Assignees: University of South Florida, University of the Sciences in PhiladelphiaInventors: Chris P. Tsokos, Abolfazl Saghafi, Sajad Jazayeri, Sanaz Esmaeili
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Patent number: 10128096Abstract: An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure. The heater is for heating the channel, and the channel is configured to generate charged particles of a sample in response to the sample being introduced into the channel.Type: GrantFiled: January 9, 2017Date of Patent: November 13, 2018Assignees: University Of The Sciences In Philadelphia, Wayne State UniversityInventors: Sarah Trimpin, Charles Nehemiah McEwen, Vincent Salvatore Pagnotti
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Patent number: 10053498Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.Type: GrantFiled: November 20, 2015Date of Patent: August 21, 2018Assignee: University of the Sciences of PhiladelphiaInventors: Zhiyu Li, Michelle Parker
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Publication number: 20170354741Abstract: Disclosed herein are high molecular weight compounds comprising gelatin and doxorubicin, where the gelatin is covalently linked to doxorubicin through a cleavable linker. The cleavable linker can be cleaved under appropriate physiological conditions, and thus lead to the freeing of doxorubicin. The free doxorubicin can then exert its cytotoxic effects on cancer cells. Disclosed herein are methods of making the high molecular weight gelatin-doxorubicin conjugates and methods of use of the same.Type: ApplicationFiled: October 30, 2015Publication date: December 14, 2017Applicant: UNIVERSITY OF THE SCIENCES IN PHILADELPHIAInventors: Clyde M. OFNER III, Chris CAMMARATA, Brian RHODES, Darren WU
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Publication number: 20170148621Abstract: An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure. The heater is for heating the channel, and the channel is configured to generate charged particles of a sample in response to the sample being introduced into the channel.Type: ApplicationFiled: January 9, 2017Publication date: May 25, 2017Applicants: UNIVERSITY OF THE SCIENCES IN PHILADELPHIA, WAYNE STATE UNIVERSITYInventors: Sarah TRIMPIN, Charles Nehemiah McEWEN, Vincent Salvatore PAGNOTTI
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Patent number: 9552973Abstract: An ionizing system includes a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region. A heater is coupled to the channel and configured to heat the channel. A device is configured to introduce an analyte into the channel where the analyte is ionized.Type: GrantFiled: September 1, 2011Date of Patent: January 24, 2017Assignees: University of the Sciences in Philadelphia, Wayne State UniversityInventors: Charles Nehemiah McEwen, Sarah Trimpin, Vincent Salvatore Pagnotti
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Patent number: 9309303Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: GrantFiled: December 3, 2013Date of Patent: April 12, 2016Assignee: The University of the Sciences in PhiladelphiaInventors: Zhlyu Li, Russell Digate
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Patent number: 9305759Abstract: An ion source able to ionize liquid and gaseous effluents from interfaced liquid or gaseous separation techniques and from direct introduction of the analyte to the entrance of the ionization region. The liquid effluents from sources such as a liquid chromatograph are ionized by inlet ionization methods and the gaseous effluents from sources such as a gas chromatograph are ionized by a corona or Townsend electrical discharge, or an alpha or beta emitter, or by inlet ionization, or by photoionization. Ionization occurs in an intermediate pressure region linking atmospheric pressure and the vacuum of the mass analyzer. The source has the ability to ionize compounds from both liquid and gaseous sources, which facilitates ionization of volatile compounds separated by gas chromatography, volatile or non-volatile compounds separated by liquid chromatography, or infused into the ionization. The ionization methods can be achieved with a single configuration or with separately optimized configurations.Type: GrantFiled: January 24, 2013Date of Patent: April 5, 2016Assignee: University of the Sciences in PhiladelphiaInventors: Charles Nehemiah McEwen, Vincent Salvatore Pagnotti
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Publication number: 20140286863Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: ApplicationFiled: December 3, 2013Publication date: September 25, 2014Applicant: The University of the Sciences in PhiladelphiaInventors: Zhlyu LI, Russell DIGATE
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Patent number: 8598311Abstract: The technology described herein is directed to conjugating various therapeutic or functional molecules, such small chemical drugs, peptides, oligonucleotides, isotopes and imaging regents with fatty acids, such as LCFAs. The fatty acid-conjugated molecules are complexed with a human serum albumin protein in vitro.Type: GrantFiled: November 20, 2008Date of Patent: December 3, 2013Assignee: The University of the Sciences in PhiladelphiaInventors: Zhlyu Li, Russell Digate
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Patent number: 8541476Abstract: The present invention comprises compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer. The invention further comprises a method of identifying novel radiosensitizing compounds.Type: GrantFiled: September 12, 2008Date of Patent: September 24, 2013Assignees: The Trustees of the University of Pennsylvania, Wake Forest University Health Sciences, University of the Sciences in PhiladelphiaInventors: Constantinos Koumenis, Brian E. Lally, Steven Kridel, Gary D. Kao, Adeboye Adejare
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Publication number: 20130214154Abstract: An ionizing system includes a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region. A heater is coupled to the channel and configured to heat the channel. A device is configured to introduce an analyte into the channel where the analyte is ionized.Type: ApplicationFiled: September 1, 2011Publication date: August 22, 2013Applicants: WAYNE STATE UNIVERSITY, UNIVERSITY OF THE SCIENCES IN PHILADELPHIAInventors: Charles Nehemiah McEwen, Vincent Salvatore Pagnotti, Sarah Trimpin
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Publication number: 20100272644Abstract: The technology described herein is directed to conjugating various therapeutic or functional molecules, such small chemical drugs, peptides, oligonucleotides, isotopes and imaging regents with fatty acids, such as LCFAs. The fatty acid-conjugated molecules are complexed with a human serum albumin protein in vitro.Type: ApplicationFiled: November 20, 2008Publication date: October 28, 2010Applicant: The University of the Sciences in PhiladelphiaInventors: Zhlyu Li, Russell Digate
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Patent number: 6624153Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: wherein X1 is a halogen and X2 is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: wherein X1 is a halogen and X2 is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.Type: GrantFiled: September 9, 2002Date of Patent: September 23, 2003Assignee: University of Sciences in PhiladelphiaInventors: Farzad Kobarfard, Joel M. Kauffman
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Patent number: 6482982Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: wherein X1 is a halogen and X2 is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: wherein X1 is a halogen and X2 is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.Type: GrantFiled: March 8, 2001Date of Patent: November 19, 2002Assignee: University of Sciences of PhiladelphiaInventors: Farzad Kobarfard, Joel M. Kauffman