Patents Assigned to University of Toledo
  • Architecture for efficient monolithic bifacial perovskite-CdSeTe tandem thin film solar cells and modules
    Patent number: 12136680
    Abstract: An optoelectronic device comprising two photovoltaic absorber materials of CdSeTe and perovskite and their functional component layers that are monolithically integrated into a bifacial tandem solar cell structure.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: November 5, 2024
    Assignee: The University of Toledo
    Inventors: Zhaoning Song, Kamala Khanal Subedi, Randy Ellingson, Yanfa Yan
  • Metabolically Stable HDAC Inhibitors with Trifluoromethylpyruvamide as Metal-Binding Group
    Publication number: 20240360089
    Abstract: HDAC inhibitor compounds having trifluoromethylpyruvamides or hydrates thereof, and methods of making and using the same, are described. The HDAC inhibitor compounds are useful for inhibiting HDAC activity and inhibiting growth of cancer cells.
    Type: Application
    Filed: February 23, 2024
    Publication date: October 31, 2024
    Applicant: The University of Toledo
    Inventors: Endri Karaj, Liyanaaratchige V. Tillekeratne, Riddhidev Banerjee, William R. Taylor
  • PRESSURE ULCER BOOT
    Publication number: 20240350351
    Abstract: A pressure ulcer boot includes a boot body formed from a layer of flexible material, an array of selectively inflatable and deflatable air pockets mounted to a portion of the boot body, an air pump in fluid communication with the array of air pockets, and a micro-processor operative to control the air pump to selectively inflate and deflate the air pockets and to apply pressure via the air pockets at regular intervals to increase circulation and relieve pressure in a portion of a patient's body with which the pressure ulcer boot is in contact.
    Type: Application
    Filed: April 19, 2024
    Publication date: October 24, 2024
    Applicant: The University of Toledo
    Inventors: Munier Nazzal, Abdullah Nasif, Karen Bauer, Mohamed Osman, Josh N. Moskall, Raelyn E. Nyren, Mathieu K. Holt, Logan K. Simmons
  • Adjustable gravity simulator for tissue and organ culturing
    Patent number: 12116560
    Abstract: Adjustable gravity simulators, mechanical loading devices, and methods for simulating gravitational loads and cell culturing are described. Further provided is an adjustable gravity simulator having a simulator chamber and a mechanical loading device configured to apply a mechanical load to samples in the simulator chamber while the simulator chamber experiences a microgravity or partial gravity simulation. Advantageously, the adjustable gravity simulator as described herein can address the challenges associated with cell culturing in simulated microgravity or partial gravity.
    Type: Grant
    Filed: February 27, 2024
    Date of Patent: October 15, 2024
    Assignee: The University of Toledo
    Inventors: Eda Yildirim-Ayan, Halim Ayan, Charles Wade
  • SOLID PHANTOM DEVICE FOR BEAM SCANNING
    Publication number: 20240325790
    Abstract: Provided is a device comprising a phantom comprising a solid water material, having a square cross-sectional shape, and having a width that varies monotonically along a height of the solid phantom; and an array of radiation detectors disposed within the phantom; wherein the array of radiation detectors is configured to detect radiation within the phantom. Further provided is a linear accelerator having a gantry and comprising the device as described herein installed in a treatment head of the gantry. In certain embodiments, the linear accelerator further comprises software to interface the device with the linear accelerator.
    Type: Application
    Filed: July 21, 2022
    Publication date: October 3, 2024
    Applicant: The University of Toledo
    Inventors: E. Ishmael Parsai, Diana Shvydka, Kanru Xie
  • Coacervate Compositions, Multifunctional Coatings, and Tie Layers for Recyclable and Active Barrier Films
    Publication number: 20240326380
    Abstract: Coacervate compositions, tie layers, coatings, moldable viscoelastic materials, sustained release materials, kits for making coacervate compositions, and methods of using and making the same are described. A coacervate composition may include a complex between a surfactant and a polyelectrolyte in a solvent, where the surfactant includes a cis double bond.
    Type: Application
    Filed: March 25, 2024
    Publication date: October 3, 2024
    Applicant: The University of Toledo
    Inventors: Yakov Lapitsky, Maria R. Coleman, Joseph G. Lawrence, Jose C. Benalcazar Bassante
  • Automatic Fraction Collector
    Publication number: 20240319053
    Abstract: An automatic fraction collector, methods of using the same, and systems including the same are described. The automatic fraction collector includes a sensor assembly able to detect liquid drops passing therethrough with light, where the sensor assembly is in the fluid flow path between a column and the point of collection of the liquid drops.
    Type: Application
    Filed: March 15, 2024
    Publication date: September 26, 2024
    Applicant: The University of Toledo
    Inventor: Shi-He Liu
  • Synergistic Inhibition of eIF5A and Notch Signaling in Intermediate Tregs
    Publication number: 20240307532
    Abstract: Methods for inducing plasticity in effector T cells or intermediate Treg cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the synergstic inhibition of eIF5A and Notch signaling. Also described are compositions and kits including an eIF5A inhibitor and a Notch signaling inhibitor.
    Type: Application
    Filed: May 21, 2024
    Publication date: September 19, 2024
    Applicant: The University of Toledo
    Inventors: Shahnawaz Imam, Shafiya Imtiaz Rafiqi
  • Smart exosomes for active PDAC targeting and evading mononuclear phagocytotic system
    Patent number: 12090213
    Abstract: Exosomes that express peptides in CD9 proteins, and smart exosomes that co-express two peptides incorporated into CD9 proteins to home delivery of the exosomes to a desired target and evade phagocytosis by macrophages, are described. Provided are exosomes useful for delivering drugs to desired targets. The exosomes comprise drugs, such as chemotherapeutic drugs, encapsulated in their core. The targets include pancreatic cancer cells.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: September 17, 2024
    Assignee: The University of Toledo
    Inventors: Shi-He Liu, Francis Charles Brunicardi
  • SUSTAINABLE METHODS TO SEPARATE AND RECOVER POLYETHYLENE AND POLYPROPYLENE FROM MIXED PLASTIC WASTE STREAMS
    Publication number: 20240246263
    Abstract: Sustainable methods to separate and recover polypropylene (PP) and polyethylene (PE) from mixed plastic wastes are described. The method utilize a class of green solvents, namely, oils, which can selectively dissolve PP, but not PE or other polymers. When re-precipitated, the recovered PP has properties similar to virgin PP.
    Type: Application
    Filed: May 17, 2022
    Publication date: July 25, 2024
    Applicant: The University of Toledo
    Inventors: Parikshit Sarda, Balakrishna Maddi, Joseph G. Lawrence, Sridhar Viamajala
  • MATERIALS AND METHODS USEFUL TO INDUCE CANCER CELL DEATH VIA METHUOSIS OR AUTOPHAGY OR A COMBINATION THEREOF
    Publication number: 20240245667
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Application
    Filed: March 29, 2024
    Publication date: July 25, 2024
    Applicant: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen A. Amawi, Paul W. Erhardt, Piyush Trivedi
  • AORTIC PUNCH
    Publication number: 20240238003
    Abstract: An aortic punch includes a cylindrical barrel, a cylindrical plunger movably mounted within the barrel, a blade shaft movably mounted within a distal end of the barrel and having a first cutting tool at a distal end thereof, the first cutting tool configured to form a first cut in a wall of a blood vessel, and a cylindrical punch body movably mounted within a distal end of the barrel and about the blade shaft and having a second, circular cutting tool configured to form a circular hole in the wall of a blood vessel around the first cut.
    Type: Application
    Filed: January 11, 2024
    Publication date: July 18, 2024
    Applicant: The University of Toledo
    Inventors: Munier Nazzal, Abdullah Nasif, Nahidh W. Hasaniya
  • METHODS OF TREATING CANCER AND ISCHEMIA DISEASES BY INHIBITION AND INTERVENTION OF ATR PROLYL ISOMERIZATION
    Publication number: 20240238282
    Abstract: Combination treatments for cancers involving inhibiting cis-ATR, as well as biomarkers for cancer diagnosis and prognosis, and transgenic animals, are described.
    Type: Application
    Filed: April 26, 2022
    Publication date: July 18, 2024
    Applicant: The University of Toledo
    Inventor: Yue Zou
  • Syndesmosis fixation and reconstruction system and method of using the same
    Patent number: 12023053
    Abstract: A fixation/reconstruction system for treating syndesmotic ankle fractures includes a screw guide assembly configured to align the cannulated screw for insertion into, and securing within, the patients bone; and, a tension band alignment assembly configured to insert at least one tension band through a transverse opening in the patient s leg, and to secure the tension band.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: July 2, 2024
    Assignee: The University of Toledo
    Inventors: Jiayong Liu, David Dick, Vijay K. Goel, Nabil A. Ebraheim
  • ADJUSTABLE GRAVITY SIMULATOR FOR TISSUE AND ORGAN CULTURING
    Publication number: 20240200014
    Abstract: Adjustable gravity simulators, mechanical loading devices, and methods for simulating gravitational loads and cell culturing are described.
    Type: Application
    Filed: February 27, 2024
    Publication date: June 20, 2024
    Applicant: The University of Toledo
    Inventors: Eda Yildirim-Ayan, Halim Ayan, Charles Wade
  • ELISA Assay for Measuring Function of Properdin and Kits for Conducting ELISA Assays using Anti-properdin Antibodies
    Publication number: 20240183863
    Abstract: Methods measuring properdin function and kits for conducting ELISA assays using anti-properdin antibodies and uses thereof are described.
    Type: Application
    Filed: January 11, 2024
    Publication date: June 6, 2024
    Applicant: The University of Toledo
    Inventor: Viviana P. Ferreira
  • COMPOUNDS HAVING SELECTIVE INACTIVATION ACTIVITY
    Publication number: 20240180158
    Abstract: In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of various fungal infections and/or other diseases. In some embodiments, a method for the inactivation of a microbial enzyme is provided comprising providing a compound having a selective inactivation activity, providing an enzyme target, and inactivating the enzyme target. In some example embodiments, the compound comprises a sulfonyl group.
    Type: Application
    Filed: January 19, 2024
    Publication date: June 6, 2024
    Applicants: University of North Carolina at Wilmington, THE UNIVERSITY OF TOLEDO
    Inventors: Christopher John HALKIDES, Ronald E. Viola
  • Nitinol organ positioner to prevent damage to healthy tissue during radiation oncology treatments
    Patent number: 11992708
    Abstract: Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: May 28, 2024
    Assignee: The University of Toledo
    Inventors: E. Ishmael Parsai, Mohammad Elahinia
  • PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME
    Publication number: 20240166613
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures. treating osteoporosis and/or metabolic bone diseases. and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: January 25, 2024
    Publication date: May 23, 2024
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • Materials and methods useful to induce cancer cell death via methuosis or autophagy or a combination thereof
    Patent number: 11986467
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: May 21, 2024
    Assignee: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen A. Amawi, Paul W. Erhardt, Piyush Trivedi