Patents Assigned to University of Ulster
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Patent number: 11878059Abstract: The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one sonosensitising agent and at least one chemotherapeutic agent. It further relates to the microbubble complexes themselves and to pharmaceutical compositions which contain them. The invention is particularly suitable for the treatment of deep-sited tumors, in particular pancreatic cancer.Type: GrantFiled: May 31, 2018Date of Patent: January 23, 2024Assignee: UNIVERSITY OF ULSTERInventors: John Callan, Anthony Mchale, Sukanta Kamila, Keiran Logan
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Patent number: 11738065Abstract: The present invention relates to polypeptides and analogues thereof for use in the treatment of diabetes and bone disorders. Also disclosed are pharmaceutical compositions comprising the polypeptides and analogues thereof, and methods for the treatment of diabetes and bone disorders.Type: GrantFiled: January 11, 2021Date of Patent: August 29, 2023Assignee: UNIVERSITY OF ULSTERInventors: Victor Gault, Nigel Irwin
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Patent number: 11712473Abstract: The present invention relates to a sensitizer-peptide conjugate for use in the treatment of cancer. In particular, the present invention relates to a sensitizer-peptide conjugate for use in the treatment of melanoma. The use of such sensitizer-peptide conjugate in photodynamic therapy or sonodynamic therapy is also disclosed. According to the present invention, there is provided a sensitizer-peptide conjugate for use in the treatment of cancer; wherein the sensitizer-peptide conjugate comprises at least one sensitizer and at least one peptide.Type: GrantFiled: June 25, 2018Date of Patent: August 1, 2023Assignee: UNIVERSITY OF ULSTERInventors: John Francis Callan, Bridgeen Callan, Anthony Patrick McHale
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Publication number: 20230193364Abstract: This invention relates to predicting a subjects responsiveness to biologic therapy of rheumatoid arthritis. The invention provides a method for predicting responsiveness to anti-tumour necrosis factor therapy of rheumatoid arthritis in a subject, the method comprising the steps of: (a) Providing a biological sample; (b) detecting the presence, absence, or quantitative level of a first marker or an expression product thereof, wherein the first marker is at the HLA DRB1 gene; (c) detecting the presence, absence, or quantitative level of a second marker, or an expression product thereof, wherein the second marker is at the CD226 gene; (d) correlating the presence, absence, or quantitative level of the first marker and the presence, absence, or quantitative level of the second marker; to the predicted responsiveness to anti-tumour necrosis factor therapy of rheumatoid arthritis in the subject.Type: ApplicationFiled: May 21, 2021Publication date: June 22, 2023Applicant: University of UlsterInventors: David Gibson, Tony Bjourson, Cathy McGough, Martin Crockard, John Lamont
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Patent number: 11559839Abstract: A method of producing nanoscale materials comprising the steps of entraining liquid droplets containing at least one nanoparticle precursor within a gaseous stream, and passing said gaseous stream containing said liquid droplets through a non-thermal equilibrium plasma whereby said plasma interacts with said at least one nanoparticle precursor to produce nanoparticles within said droplets without substantial evaporation of the droplets and conveying the thus produced nanoparticles within said gaseous stream downstream of said plasma.Type: GrantFiled: January 22, 2018Date of Patent: January 24, 2023Assignee: University of UlsterInventors: Davide Mariotti, Paul Maguire
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Patent number: 11541019Abstract: This invention relates to compositions for use in the treatment of diabetes, for example type-2 diabetes; obesity; and/or metabolic syndrome. Specifically, the invention relates to a composition for use in the treatment of diabetes, the composition comprising at least one of diindolylmethane; indole-3-carbinol; embelin; [6]-gingerol; and [6]-shogaol, or combinations each thereof. Also disclosed is use in the treatment of obesity and use in the treatment of metabolic syndrome.Type: GrantFiled: August 27, 2020Date of Patent: January 3, 2023Assignee: University of UlsterInventors: Aine Maire McKillop, Peter Raymond Flatt
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Patent number: 11508925Abstract: A photovoltaic device (10) comprising a photoactive body between two electrodes (contact 1, contact 2). The body comprises semiconductor particles (24) embedded in a semiconductor matrix (22). The particles and matrix are electronically or optically coupled so that charge carriers generated in the particles are transferred directly or indirectly to the matrix. The matrix transports positive charge carriers to one of the electrodes and negative charge carriers to the other electrode. The particles are configured so that they do not form a charge carrier transport network to either of the electrodes and so perform the function of charge carrier generation but not charge carrier transport.Type: GrantFiled: July 18, 2016Date of Patent: November 22, 2022Assignee: UNIVERSITY OF ULSTERInventor: Davide Mariotti
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Publication number: 20220347314Abstract: The invention relates to methods of sonodynamic therapy comprising the co-administration of a microbubble-chemotherapeutic agent complex together with a microbubble-sonosensitiser complex. It further relates to pharmaceutical compositions comprising these complexes and their use in methods of sonodynamic therapy and/or sonodynamic diagnosis. Such methods find particular use in the treatment of cancer, e.g. pancreatic cancer.Type: ApplicationFiled: May 2, 2022Publication date: November 3, 2022Applicant: UNIVERSITY OF ULSTERInventors: John CALLAN, Anthony MCHALE, Eleanor STRIDE
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Patent number: 11382987Abstract: The invention relates to methods of sonodynamic therapy comprising the co-administration of a microbubble-chemotherapeutic agent complex together with a microbubble-sonosensitiser complex. It further relates to pharmaceutical compositions comprising these complexes and their use in methods of sonodynamic therapy and/or sonodynamic diagnosis. Such methods find particular use in the treatment of cancer, e.g. pancreatic cancer.Type: GrantFiled: November 23, 2016Date of Patent: July 12, 2022Assignee: University of UlsterInventors: John Callan, Anthony McHale, Eleanor Stride
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Publication number: 20220041739Abstract: The present disclosure concerns modulators of the NLRP3 inflammasome pathway, in particular an NLRP3 inflammasome modulator which is capable of binding to both of IL-1R1 and NLRP3, for use in the treatment or prophylaxis of inflammatory eye diseases such as glaucoma.Type: ApplicationFiled: September 16, 2019Publication date: February 10, 2022Applicant: University of UlsterInventor: Victoria McGILLIGAN
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Publication number: 20220033507Abstract: The present disclosure concerns modulators of the NLRP3 inflammasome pathway, in particular an NLRP3 inflammasome modulator which is capable of binding to both of IL-IR1 and NLRP3.Type: ApplicationFiled: September 16, 2019Publication date: February 3, 2022Applicant: University of UlsterInventor: Victoria McGILLIGAN
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Patent number: 11235000Abstract: The invention provides CaO2 nanoparticles having a pH-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxygen to exert their effect, such as photodynamic therapy (PDT), sonodynamic therapy (SDT), and radiotherapy. The invention also provides pharmaceutical compositions containing the coated CaO2 nanoparticles, together with at least one photosensitiser, sonosensitiser, or radiosensitiser and, optionally, at least one pharmaceutical carrier or excipient.Type: GrantFiled: May 4, 2018Date of Patent: February 1, 2022Assignee: UNIVERSITY OF ULSTERInventors: Anthony Mchale, John Callan, Yingjie Sheng
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Publication number: 20210379157Abstract: The present invention relates to polypeptides and analogues thereof for use in the treatment of diabetes and bone disorders. Also disclosed are pharmaceutical compositions comprising the polypeptides and analogues thereof, and methods for the treatment of diabetes and bone disorders.Type: ApplicationFiled: January 11, 2021Publication date: December 9, 2021Applicant: UNIVERSITY OF ULSTERInventors: Victor GAULT, Nigel IRWIN
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Patent number: 11191973Abstract: An external transmitter apparatus for a transcutaneous energy transfer (TET) system for supplying power for use in energising an implantable medical device is disclosed, the apparatus comprising an external transmitter apparatus comprising a plurality of transmitter coils for delivering power transcutaneously to one of a plurality of receiver coils of an implantable receiver apparatus of the TET system when located in proximity thereto. The external transmitter apparatus is provided with power by a pulsed power supply. The coils of the external transmitter apparatus and the implantable receiver apparatus may be printed on flexible substrates. Also disclosed are methods of operating such a system, an external transmitter apparatus for use in such a system, an external transmitter apparatus and an implantable receiver apparatus including flexible coils.Type: GrantFiled: July 29, 2016Date of Patent: December 7, 2021Assignee: University of UlsterInventors: Omar Jacinto Escalona, David John McEneaney, James McLaughlin
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Publication number: 20210228679Abstract: The present invention relates to peptides for use in the treatment of metabolic disorders. In particular, the present invention relates to peptides for use in the treatment of diabetes. According to the present invention, there is provided a peptide for use in the treatment of a metabolic disorder; wherein the peptide is a piscine-derived PYY or fragment or analogue thereof.Type: ApplicationFiled: April 26, 2019Publication date: July 29, 2021Applicant: University of UlsterInventors: Nigel Irwin, Peter Raymond Flatt
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Publication number: 20200114003Abstract: The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one sonosensitising agent and at least one chemotherapeutic agent. It further relates to the microbubble complexes themselves and to pharmaceutical compositions which contain them. The invention is particularly suitable for the treatment of deep-sited tumors, in particular pancreatic cancer.Type: ApplicationFiled: May 31, 2018Publication date: April 16, 2020Applicant: UNIVERSITY OF ULSTERInventors: John CALLAN, Anthony MCHALE, Sukanta KAMILA, Keiran LOAGAN
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Patent number: 10603710Abstract: A reconfigurable stretch forming apparatus includes an array of pins adapted to be individually adjustable in height to define a reconfigurable forming surface, a pair of counter-rotating workpiece gripping devices being provided on opposite sides of the array of pins, each gripping device having an arcuate support surface for supporting a workpiece and a clamp member for clamping a work piece against the arcuate support surface, a driver being provided for rotating the counter-rotating gripping devices in opposing directions to stretch the work piece over the forming surface.Type: GrantFiled: January 27, 2015Date of Patent: March 31, 2020Assignee: University of UlsterInventor: Alan Leacock
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Publication number: 20200069727Abstract: The invention provides CaO2 nanoparticles having a pH-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxygen to exert their effect, such as photodynamic therapy (PDT), sonodynamic therapy (SDT), and radiotherapy. The invention also provides pharmaceutical compositions containing the coated CaO2 nanoparticles, together with at least one photosensitiser, sonosensitiser, or radiosensitiser and, optionally, at least one pharmaceutical carrier or excipient.Type: ApplicationFiled: May 4, 2018Publication date: March 5, 2020Applicant: UNIVERSITY OF ULSTERInventors: Anthony MCHALE, John CALLAN, Yingjie SHENG
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Patent number: 10550352Abstract: A method of extracting oil from oilseed comprising pressing seeds within a screw press including a screw auger rotatably mounted within a cylindrical expeller body, wherein the expeller body comprises a feed section, a compression section, and a discharge section, wherein at least one outlet is provided in the expeller body, preferably in or adjacent the feed section of the expeller, said method comprising the step of controlling the temperature of at least the compression section of the expeller by means such that the temperature of the material within the compression section does not exceed the glass transition temperature of the seeds.Type: GrantFiled: March 31, 2015Date of Patent: February 4, 2020Assignee: University of UlsterInventors: Neil James Hewitt, Marcio Fernandes Novaes
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Publication number: 20190091294Abstract: The present invention relates to polypeptides and analogues thereof for use in the treatment of diabetes and bone disorders. Also disclosed are pharmaceutical compositions comprising the polypeptides and analogues thereof, and methods for the treatment of diabetes and bone disorders.Type: ApplicationFiled: December 5, 2016Publication date: March 28, 2019Applicant: UNIVERSITY OF ULSTERInventors: Victor GAULT, Nigel IRWIN