Patents Assigned to University of Utah
  • Substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
    Patent number: 9266838
    Abstract: In one aspect, the invention relates to substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: February 23, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Bret Stephens, David J. Bearss, Sunil Sharma
  • Multidirectional controller with shear feedback
    Patent number: 9268401
    Abstract: A multidirectional control system with shear feedback, comprising at least one stationary body, a plurality of tactors disposed within the at least one movable body or the at least one stationary body. In some embodiments, a moveable body is included, such that the tactors have at least one degree of freedom of motion with respect to the stationary body or the moveable body within which they are disposed and are operable to engage target areas of a user's skin; and a plurality of actuators capable of moving the tactors.
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: February 23, 2016
    Assignee: University of Utah Research Foundation
    Inventor: William R. Provancher
  • Dynamic collimation for computed tomography
    Patent number: 9259191
    Abstract: A collimator for a computed tomography imaging device can include first and second leaves positioned on and bounding opposing sides of a radiation delivery window. The first and second leaves can be movable to adjust at least one of a size or a location of the primary radiation delivery window relative a the radiation source in a direction non-parallel to an axis of rotation of the radiation source.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: February 16, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Frederic Noo, Dominic Heuscher
  • APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME
    Publication number: 20160038484
    Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT 6) receptor antagonists are provided for improving the cognition of a Down syndrome patient. Through the use of a mouse model of DS, the Ts65Dn mouse, we disclose evidence herein that 5-HT 6 receptor antagonists may alleviate the cognitive deficits observed in human subjects suffering from DS. Species within the claimed genus of 5-HT6 receptor antagonists restored the cognitive function of Ts65Dn mice almost to the level of control mice as demonstrated by an improved ability to differentiate between a familiar object in a familiar location and a novel object in a novel location. Consequently, the data disclosed herein support the claimed use of 5-HT 6 receptor antagonists for the treatment of cognitive deficits associated with DS.
    Type: Application
    Filed: April 3, 2014
    Publication date: February 11, 2016
    Applicant: The University of Utah Research Foundation
    Inventors: Julie Ruth Korenberg, Karen Sue Wilcox, Peter Jeffrey West, Raymond Pierre Kesner
  • MORPHOLINOS, MORPHOLINO UPREGULATING, AND ASSOCIATED METHODS
    Publication number: 20160040169
    Abstract: Various methods and compositions relating to vascular endothelial growth factor receptor 2 (VEGFR2) are provided.
    Type: Application
    Filed: November 15, 2012
    Publication date: February 11, 2016
    Applicant: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Hironori Uehara
  • Optically guided medical tube and control unit assembly and methods of use
    Patent number: 9254245
    Abstract: An optical medical tube and control unit assembly and methods of using the same are provided. The optical medical tube may include a steering mechanism and an imaging device which provides the user a visual aid when placing a tube in the body of a patient. The optical medical tube may be coupled to a coupling adaptor to enable quick and easy connecting of the imaging device and steering mechanism of the tube with a control unit such that a single control unit may be used to place multiple feeding tubes or confirm that a feeding tube remains in its proper position without the need for lengthy sterilization procedures between uses.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: February 9, 2016
    Assignee: University of Utah
    Inventors: Timothy R. Nieman, Trent J. Perry
  • Constructs for making induced pluripotent stem cells
    Patent number: 9228204
    Abstract: Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating iPS cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: January 5, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Stefan M. Pulst, Sharan Paul, Warunee Dansithong
  • Method and system for report generation including extensible data
    Patent number: 9224179
    Abstract: A method of extending a user interface to include additional data fields is provided. A first response is received at a first application. The first response indicates a selection of an add button associated with addition of a data field to a first window associated with a user interface of a second application. A second window is presented to a user of the first application. A second response is received at the first application. The second response includes a name for the data field entered by the user using the presented second window and a data type of the data field. A position of the data field is identified on the first window. The received name, the received data type, and the identified position for the data field are stored. The data field is presented in the first window at the stored position using the stored name when a second user executes the second application.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: December 29, 2015
    Assignee: The University of Utah Research Foundation
    Inventors: Samir Courdy, Cynthia Spigle, Carolyn Ross, Tonya Di Sera, Cody Haroldsen, Jason Holmberg
  • Methods of use comprising a biocidal polyamine
    Patent number: 9220267
    Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: December 29, 2015
    Assignees: Curza Global, LLC, University of Utah Research Foundation
    Inventors: Dustin Williams, Ryan Looper, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hari Kanna Reddy
  • Ultrasonic temperature measurement device
    Patent number: 9212956
    Abstract: An ultrasonic thermometer for measuring a temperature profile along a measurement axis of a structure, comprising a continuous measurement pathway of a structure (310) having a longitudinal measurement axis and proximal (202) and distal ends (204), and at least two backscatterers (332) formed therein transverse to the longitudinal axis and separated by a predetermined separation distance.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: December 15, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Mikhail Skliar, Kevin Whitty, Anthony Butterfield
  • Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
    Patent number: 9206176
    Abstract: In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: December 8, 2015
    Assignee: University of Utah Research Foundation
    Inventors: David J. Bearss, Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Sunil Sharma
  • Integrated surgical cutting system
    Patent number: 9198731
    Abstract: Integrated surgical systems and methods for using same are provided that can receive scanned images and produce a three dimensional model from the images. Based at least in part on the three dimensional model, a processor generates code defining an optimized tool path, which is sent to a surgical machining system that can machine the desired portion of the patient. In one exemplary aspect, the integrated system operates in a clearly defined and pre-programmed manner with no necessity for in-situ sensory or guidance feedback.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: December 1, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Alagar K. Balaji, William T. Couldwell, Charles L. Thomas, Joel D. MacDonald, Bradley C. Hansen, Aniruddha LaPalikar, Bharat Thakkar
  • Dynamic power control of computed tomography radiation source
    Patent number: 9198626
    Abstract: A method of contrast-enhanced computed tomography (CT) imaging can include repeatedly scanning a target region an applied power during a session. The applied power can be a first power for a first scan. After the first scan, the applied power for each of a plurality of scans can be selected based on an algorithm. The algorithm can be based on, for example, the attenuation indicated from a preceding scan in the session.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: December 1, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Dominic Heuscher, Frederic Noo
  • Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
    Patent number: 9192600
    Abstract: The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: November 24, 2015
    Assignee: The University of Utah Research Foundation
    Inventor: Tianxin Yang
  • SODIUM CHANNEL SENSITIVE CONOPEPTIDES AND ANALOGS, INCLUDING COMPOSITIONS AND METHODS THEREOF
    Publication number: 20150322120
    Abstract: The present invention relates to conopeptides that are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which block the sodium channels.
    Type: Application
    Filed: April 17, 2013
    Publication date: November 12, 2015
    Applicants: University of Utah Research Foundation, Janssen Pharmaceutica NV
    Inventors: Julita Imperial, Brad Reed Green, Joanna Gajewiak, Minmin Zhang, Doju Yoshikami, Grzegorz Bulaj, Baldomero Olivera, Alan Wickenden, Yi Liu
  • Methods of treating breast cancer with taxane therapy
    Patent number: 9181588
    Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 10, 2015
    Assignees: The University of Utah Research Foundation, British Columbia Cancer Agency Branch, Washington University, The University of North Carolina at Chapel Hill, Bioclassifier, LLC
    Inventors: Charles M. Perou, Philip S. Bernard, Torsten O. Nielsen, Matthew J. Ellis, Joel S. Parker, Miguel Martin, Eva Carrasco, Rosalia Caballero
  • Methods of predicting mortality risk by determining telomere length
    Patent number: 9169516
    Abstract: The present invention provides for methods of determining telomere length of an organism and correlating the measured telomere length with mortality risk associated with telomere length in a population. The presence of shorter telomeres is associated with an increased mortality rate and increased susceptibility to certain types of diseases for an individual member of a human population.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: October 27, 2015
    Assignee: University of Utah Research Foundation
    Inventor: Richard Cawthon
  • ACTIVATED NITRIC OXIDE DONORS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20150290224
    Abstract: Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment and prevention are also described herein.
    Type: Application
    Filed: April 13, 2015
    Publication date: October 15, 2015
    Applicant: University of Utah Research Foundation
    Inventors: Paul J. Shami, Ken M. Kosack
  • Polymeric Articles Having a Nanoscopically and/or Microscopically Rough Surface, Methods of Use thereof, and Methods for Fabrication Thereof
    Publication number: 20150289751
    Abstract: Polymeric articles that include a nanoscopically and/or microscopically rough surface formed on at least a portion of the article. Methods of using and making such articles are also disclosed. In one embodiment, covers for use with a surgical viewing instrument that include the nanoscopically and/or microscopically rough surface are disclosed. The cover includes a cover configured for placement over at least a portion of a surgical viewing instrument, at least a portion of the cover being transparent to light, and a nanoscopically and/or microscopically rough surface formed on at least a portion of the cover. The nanoscopically and/or microscopically rough surface is configured to shed and/or incorporate into a thin, substantially uniform film such droplets, fogs, and debris for providing clearer and less obstructed vision at a surgical, diagnostic or procedure site.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 15, 2015
    Applicant: University of Utah Research Foundation
    Inventors: Micah J. Frerck, Alex J. Drew, Branden D. Rosenhan
  • Virtual electrodes for high-density electrode arrays
    Patent number: 9155879
    Abstract: The present embodiments are directed to implantable electrode arrays having virtual electrodes. The virtual electrodes may improve the resolution of the implantable electrode array without the burden of corresponding complexity of electronic circuitry and wiring. In a particular embodiment, a virtual electrode may include one or more passive elements to help steer current to a specific location between the active electrodes. For example, a passive element may be a metalized layer on a substrate that is adjacent to, but not directly connected to an active electrode. In certain embodiments, an active electrode may be directly coupled to a power source via a conductive connection. Beneficially, the passive elements may help to increase the overall resolution of the implantable array by providing additional stimulation points without requiring additional wiring or driver circuitry for the passive elements.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: October 13, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Carlos J. Cela, Gianluca Lazzi